VWA3B_HUMAN
ID VWA3B_HUMAN Reviewed; 1294 AA.
AC Q502W6; B9EK71; Q86T73; Q8N2D0; Q8N770; Q8NA79; Q8ND63; Q8ND65; Q8WW02;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=von Willebrand factor A domain-containing protein 3B;
DE Short=VWA domain-containing protein 3B;
GN Name=VWA3B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 7), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 591-1294 (ISOFORM 6), AND VARIANTS MET-885
RP AND LYS-1245.
RC TISSUE=Amygdala, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 8), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 492-1294 (ISOFORM 1), AND VARIANTS VAL-677;
RP MET-885 AND LYS-1245.
RC TISSUE=Spinal cord, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT
RP LYS-1245.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT SCAR22 THR-622, INVOLVEMENT IN SCAR22, VARIANT TRP-181, AND
RP SUBCELLULAR LOCATION.
RX PubMed=26157035; DOI=10.1136/jnnp-2014-309828;
RA Kawarai T., Tajima A., Kuroda Y., Saji N., Orlacchio A., Terasawa H.,
RA Shimizu H., Kita Y., Izumi Y., Mitsui T., Imoto I., Kaji R.;
RT "A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual
RT disability.";
RL J. Neurol. Neurosurg. Psych. 87:656-662(2016).
RN [6]
RP VARIANT MET-42.
RX PubMed=26566883; DOI=10.1136/jmedgenet-2015-103179;
RA Rafiullah R., Aslamkhan M., Paramasivam N., Thiel C., Mustafa G.,
RA Wiemann S., Schlesner M., Wade R.C., Rappold G.A., Berkel S.;
RT "Homozygous missense mutation in the LMAN2L gene segregates with
RT intellectual disability in a large consanguineous Pakistani family.";
RL J. Med. Genet. 53:138-144(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26157035}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=1;
CC IsoId=Q502W6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q502W6-2; Sequence=VSP_033838, VSP_033839;
CC Name=3;
CC IsoId=Q502W6-3; Sequence=VSP_033834, VSP_033840;
CC Name=4;
CC IsoId=Q502W6-4; Sequence=VSP_033834, VSP_033840, VSP_033843;
CC Name=5;
CC IsoId=Q502W6-5; Sequence=VSP_033836, VSP_033837;
CC Name=6;
CC IsoId=Q502W6-6; Sequence=VSP_033844;
CC Name=7;
CC IsoId=Q502W6-7; Sequence=VSP_033835;
CC Name=8;
CC IsoId=Q502W6-8; Sequence=VSP_033841, VSP_033842;
CC -!- DISEASE: Spinocerebellar ataxia, autosomal recessive, 22 (SCAR22)
CC [MIM:616948]: A form of spinocerebellar ataxia, a clinically and
CC genetically heterogeneous group of cerebellar disorders due to
CC degeneration of the cerebellum with variable involvement of the
CC brainstem and spinal cord. SCAR22 patients manifest variable severity
CC of intellectual disability associated with adult-onset cerebellar
CC ataxia. {ECO:0000269|PubMed:26157035}. Note=The disease may be caused
CC by variants affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04047.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD89964.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 8]:
CC Sequence=CAD89964.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK090786; BAC03518.1; -; mRNA.
DR EMBL; AK093084; BAC04047.1; ALT_INIT; mRNA.
DR EMBL; AK098841; BAC05431.1; -; mRNA.
DR EMBL; AK292397; BAF85086.1; -; mRNA.
DR EMBL; AL832635; CAD89964.1; ALT_FRAME; mRNA.
DR EMBL; AL834173; CAD38871.1; -; mRNA.
DR EMBL; AL834385; CAD39048.1; -; mRNA.
DR EMBL; AC018691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022028; AAH22028.1; -; mRNA.
DR EMBL; BC095480; AAH95480.1; -; mRNA.
DR EMBL; BC150653; AAI50654.1; -; mRNA.
DR CCDS; CCDS42718.1; -. [Q502W6-1]
DR RefSeq; NP_001332793.1; NM_001345864.1.
DR RefSeq; NP_659429.4; NM_144992.4. [Q502W6-1]
DR RefSeq; XP_005263954.1; XM_005263897.2. [Q502W6-6]
DR AlphaFoldDB; Q502W6; -.
DR SMR; Q502W6; -.
DR BioGRID; 128324; 12.
DR IntAct; Q502W6; 2.
DR STRING; 9606.ENSP00000417955; -.
DR iPTMnet; Q502W6; -.
DR PhosphoSitePlus; Q502W6; -.
DR BioMuta; VWA3B; -.
DR DMDM; 296439299; -.
DR EPD; Q502W6; -.
DR jPOST; Q502W6; -.
DR MassIVE; Q502W6; -.
DR MaxQB; Q502W6; -.
DR PaxDb; Q502W6; -.
DR PeptideAtlas; Q502W6; -.
DR PRIDE; Q502W6; -.
DR ProteomicsDB; 62390; -. [Q502W6-1]
DR ProteomicsDB; 62391; -. [Q502W6-2]
DR ProteomicsDB; 62392; -. [Q502W6-3]
DR ProteomicsDB; 62393; -. [Q502W6-4]
DR ProteomicsDB; 62394; -. [Q502W6-5]
DR ProteomicsDB; 62395; -. [Q502W6-6]
DR ProteomicsDB; 62396; -. [Q502W6-7]
DR ProteomicsDB; 62397; -. [Q502W6-8]
DR Antibodypedia; 52631; 89 antibodies from 17 providers.
DR DNASU; 200403; -.
DR Ensembl; ENST00000433678.5; ENSP00000388158.1; ENSG00000168658.19. [Q502W6-2]
DR Ensembl; ENST00000477737.6; ENSP00000417955.1; ENSG00000168658.19. [Q502W6-1]
DR Ensembl; ENST00000614454.1; ENSP00000484764.1; ENSG00000168658.19. [Q502W6-3]
DR GeneID; 200403; -.
DR KEGG; hsa:200403; -.
DR MANE-Select; ENST00000477737.6; ENSP00000417955.1; NM_144992.5; NP_659429.4.
DR UCSC; uc002syo.4; human. [Q502W6-1]
DR CTD; 200403; -.
DR DisGeNET; 200403; -.
DR GeneCards; VWA3B; -.
DR HGNC; HGNC:28385; VWA3B.
DR HPA; ENSG00000168658; Group enriched (fallopian tube, testis).
DR MalaCards; VWA3B; -.
DR MIM; 614884; gene.
DR MIM; 616948; phenotype.
DR neXtProt; NX_Q502W6; -.
DR OpenTargets; ENSG00000168658; -.
DR PharmGKB; PA162409004; -.
DR VEuPathDB; HostDB:ENSG00000168658; -.
DR eggNOG; ENOG502QV6D; Eukaryota.
DR GeneTree; ENSGT00940000157237; -.
DR HOGENOM; CLU_023600_0_0_1; -.
DR InParanoid; Q502W6; -.
DR OMA; QSWIRDM; -.
DR OrthoDB; 580729at2759; -.
DR PhylomeDB; Q502W6; -.
DR TreeFam; TF328978; -.
DR PathwayCommons; Q502W6; -.
DR SignaLink; Q502W6; -.
DR BioGRID-ORCS; 200403; 9 hits in 1063 CRISPR screens.
DR ChiTaRS; VWA3B; human.
DR GenomeRNAi; 200403; -.
DR Pharos; Q502W6; Tdark.
DR PRO; PR:Q502W6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q502W6; protein.
DR Bgee; ENSG00000168658; Expressed in bronchial epithelial cell and 120 other tissues.
DR ExpressionAtlas; Q502W6; baseline and differential.
DR Genevisible; Q502W6; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR032770; DUF4537.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF15057; DUF4537; 1.
DR Pfam; PF13768; VWA_3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Disease variant; Intellectual disability;
KW Neurodegeneration; Reference proteome.
FT CHAIN 1..1294
FT /note="von Willebrand factor A domain-containing protein
FT 3B"
FT /id="PRO_0000337040"
FT DOMAIN 508..684
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 732..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..878
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033834"
FT VAR_SEQ 1..724
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033835"
FT VAR_SEQ 1..608
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033836"
FT VAR_SEQ 609..612
FT /note="RPDQ -> MCII (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033837"
FT VAR_SEQ 613..624
FT /note="PPETVIDQVKRF -> GTSSHLLLTAAV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033838"
FT VAR_SEQ 625..1294
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033839"
FT VAR_SEQ 879..890
FT /note="VLDKHVVSKVFD -> MATKGMRLKSTK (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033840"
FT VAR_SEQ 1054..1080
FT /note="VVKKCVSRTQALVGFSYGDTKVVSTSF -> SFFFFNFVRLLLNNLILGTRS
FT FNLCFC (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033841"
FT VAR_SEQ 1081..1294
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033842"
FT VAR_SEQ 1236..1294
FT /note="SCQGTHPEPRTAHLHFPAAGRLGLSSHAIIATPPPRAALPCTLQATHSSKGL
FT RSVPETL -> PPPLPRGRASRTQQPRHHCHTSTSSSPALYSPSHPQQQRAEERP (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033843"
FT VAR_SEQ 1246..1294
FT /note="TAHLHFPAAGRLGLSSHAIIATPPPRAALPCTLQATHSSKGLRSVPETL ->
FT VWVMGGEHNIAYLRNTLKSLSRIVHLTSSFRFWACLGSSAAKTLTSLSNAELCFPRQPT
FT STSPRPGV (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033844"
FT VARIANT 42
FT /note="L -> M (in dbSNP:rs200359284)"
FT /evidence="ECO:0000269|PubMed:26566883"
FT /id="VAR_076433"
FT VARIANT 181
FT /note="R -> W (in dbSNP:rs2305355)"
FT /evidence="ECO:0000269|PubMed:26157035"
FT /id="VAR_043571"
FT VARIANT 622
FT /note="K -> T (in SCAR22; dbSNP:rs876657414)"
FT /evidence="ECO:0000269|PubMed:26157035"
FT /id="VAR_075091"
FT VARIANT 677
FT /note="L -> V (in dbSNP:rs7601049)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_043572"
FT VARIANT 885
FT /note="V -> M (in dbSNP:rs11889349)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_043573"
FT VARIANT 1103
FT /note="I -> M (in dbSNP:rs6731704)"
FT /id="VAR_057022"
FT VARIANT 1223
FT /note="D -> E (in dbSNP:rs17428626)"
FT /id="VAR_043574"
FT VARIANT 1245
FT /note="R -> K (in dbSNP:rs7587534)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_043575"
FT VARIANT 1277
FT /note="T -> I (in dbSNP:rs2271038)"
FT /id="VAR_043576"
FT CONFLICT 348
FT /note="C -> R (in Ref. 2; CAD89964)"
FT /evidence="ECO:0000305"
FT CONFLICT 416
FT /note="R -> C (in Ref. 2; CAD89964)"
FT /evidence="ECO:0000305"
FT CONFLICT 617
FT /note="V -> F (in Ref. 1; BAC04047)"
FT /evidence="ECO:0000305"
FT CONFLICT 731
FT /note="K -> R (in Ref. 2; CAD89964)"
FT /evidence="ECO:0000305"
FT CONFLICT 889
FT /note="F -> L (in Ref. 2; CAD89964)"
FT /evidence="ECO:0000305"
FT CONFLICT 1171
FT /note="D -> G (in Ref. 4; AAH22028)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1294 AA; 145748 MW; 97D11C329C31060D CRC64;
MEKSGPSSTI SEQQLQRQEG WINTKTDLAE QSLISSEKWL QLHGLKSNKL TLKQILSQIG
FPHCEDYVAS LGRPVASRYA DGLFPQLYRA EDGRVYNLTA KSELIYQFVE HLTQAVESYK
QRMDWLTSKS RQIFGVILEQ CVTIVLDFGG ILEGELDLCR EALTMVLQEQ VAHITEFNII
RVSQEPVKWQ ENATPVTEQS IATAISWVEK LTVELTVSEA GRLDALLEAG RDKTIESIYY
FVVGDVPEES KELLLQRALE IPCPVYTVSF NARGEGTIAF LKDLSAKTHS RFHAFAERTE
CVEFPAFSTK DGDNVMTWNS RKLKGKLPPG AGVREDVFLV WQEMEEACST LAQIQRLVAE
PPKPDVATVD CESETTSVEI ASNPEDTWDS KTWLQKYGLK AQKLSLYDVL ADCSFRHADG
VVDIKAKPEN ESVQTSAETN KKTVHAKYCS RFVHAPWKDG SLVHVNITKE KCKWYSERIH
TALARIRRRI KWLQDGSQSL FGRLHNDCIY ILIDTSHSMK SKLDLVKDKI IQFIQEQLKY
KSKFNFVKFD GQAVAWREQL AEVNEDNLEQ AQSWIRDIKI GSSTNTLSAL KTAFADKETQ
AIYLLTDGRP DQPPETVIDQ VKRFQEIPIY TISFNYNDEI ANRFLKEVAA LTGGEFHFYN
FGCKDPTPPE AVQNEDLTLL VKEMEQGHSD LEKMQDLYSE SLIMDWWYNA EKDGDSKHQK
EICSMISTPE KCAKPQSDVD STQTSSLNML KGPWGLSDQK VQKKKVLHAE STKTSLLRSQ
MSSLRSSACS ERKDGLSNAS SRRTALSDKE MSILLAEEWL DDKSSEKVTR EGSQVYDHDS
SDVSSENWLK TYGLVAKKLT LMDALSVAAV PHSSTYVPVL DKHVVSKVFD EVFPLAHVCN
DTNKMTLINP QGAKLNIYKR KVEQAIQSYE KRLNKIVWRA LSQEEKEKLD ANKPIQYLEN
KTVLNQALER LNWPISLKEL SMLESEILAG KMYIQQAMEL QEAAKKNYAN KAPGEQQKLQ
GNPTKKTKSK RPDPLKGQKV IARCDENGFY FPGVVKKCVS RTQALVGFSY GDTKVVSTSF
ITPVGGAMPC PLLQVGDYVF AKIVIPKGFD FYVPAIVIAL PNKHVATEKF YTVLKCNNRR
EFCPRSALIK ISQNKYALSC SHIKSPPIPE DPEVEDVEAR NSAFLFWPLK EADTQDSREP
RREKPRRKKR PAKQPLQQAA PSDSDGSSHG ISSHGSCQGT HPEPRTAHLH FPAAGRLGLS
SHAIIATPPP RAALPCTLQA THSSKGLRSV PETL
