ID   VWA5A_RAT               Reviewed;         822 AA.
AC   Q75WE7;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=von Willebrand factor A domain-containing protein 5A;
DE   AltName: Full=Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog;
DE   AltName: Full=Mast cell surface antigen 1;
DE            Short=Masa-1;
GN   Name=Vwa5a; Synonyms=Loh11cr2a, Masa1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Matsui T., Takagi H., Shiono H., Sakai J., Isaka K., Matsui S.,
RA   Morishita M., Kondo K., Kato S., Sugiyama H., Shibata M., Atsumi F.,
RA   Okada T.;
RT   "Mast cell surface antigen-1 (Masa-1); a novel marker for mast cell
RT   activation.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in tumorigenesis as a tumor suppressor.
CC       Altered expression of this protein and disruption of the molecular
CC       pathway it is involved in may contribute directly to or modify
CC       tumorigenesis (By similarity). {ECO:0000250}.
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DR   EMBL; AB121446; BAC98429.1; -; mRNA.
DR   RefSeq; NP_942050.1; NM_198755.1.
DR   RefSeq; XP_006235564.1; XM_006235502.3.
DR   RefSeq; XP_006242901.1; XM_006242839.3.
DR   RefSeq; XP_017447766.1; XM_017592277.1.
DR   AlphaFoldDB; Q75WE7; -.
DR   SMR; Q75WE7; -.
DR   STRING; 10116.ENSRNOP00000000211; -.
DR   iPTMnet; Q75WE7; -.
DR   PhosphoSitePlus; Q75WE7; -.
DR   jPOST; Q75WE7; -.
DR   PaxDb; Q75WE7; -.
DR   PRIDE; Q75WE7; -.
DR   GeneID; 301097; -.
DR   KEGG; rno:301097; -.
DR   UCSC; RGD:735145; rat.
DR   CTD; 4013; -.
DR   RGD; 735145; Vwa5a.
DR   eggNOG; ENOG502QRPK; Eukaryota.
DR   HOGENOM; CLU_003826_4_0_1; -.
DR   InParanoid; Q75WE7; -.
DR   OrthoDB; 955432at2759; -.
DR   PhylomeDB; Q75WE7; -.
DR   TreeFam; TF329720; -.
DR   PRO; PR:Q75WE7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Tumor suppressor.
FT   CHAIN           1..822
FT                   /note="von Willebrand factor A domain-containing protein
FT                   5A"
FT                   /id="PRO_0000084413"
FT   DOMAIN          1..131
FT                   /note="VIT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT   DOMAIN          281..469
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          657..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..676
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  91483 MW;  E64CD18EC083EA8F CRC64;
     MEHHWGLITG NKEKVPLKSI SVTLSINDFV AAVAATLHYE NEEKVPIEAM FVFPMDEDSA
     VYSFEALVDG KKIVAELQDK TKAHSKYEEA LSQGHQAYLL EEDDYSRDVF SCNVGNLQPG
     TKVAVTLRYV QELPLESDGA LRYLLPAVLN PRYQLSEQSA SSCLNVQKPI VPLEALPYTL
     SMVATITSQH GIERVQSNCS LSPIQYLTDD KTSAQVSLTE GHKFDRDVEL LIYYREVHSP
     SVAVEKGMQD KKRDSLMGAP CAMVSFYPDI PEVNASKVCG EFVFLMDRSG SMQTPMRTEE
     NSQLRIEAAK ETLLLLLKSL PMGCYFNIYG FGSSYEQFFP ESVKYTQETI EEAVERVKRL
     DADLGGTEIL TPLRNIYKTS SIPGHPLQLF VFTDGEVSDT YSVIREVKLN SKKHRCFSFG
     IGQGASTSLI KNIARVSGGT AEFITGKDRM QAKALGSLKL ALQCALDDIS LSWELPPGLS
     VNMLSPEQPT IFRGQRLIIY AQLTGPMPQA ESRGAVCLKH TLQGKSLENK VAFSLQPKEN
     ANFTIHRLAA KFLIQTKDLG SHEVSKEEKK DVMNISLQSG VLSSFTAFVA INKELNKPVQ
     GPLAHRVIPR PMIATSTSMF MRSCSRLTGP FKNSRLKRRL CAADYVPYGH ESTVYSSMPS
     PAPIENQGVA DSSNEKSNSQ NEHKAFGENV VLQLIFLQNA NGSWKLDENL TKILGTTLED
     TKAANPSQHG DPSAWATILA VLWLHANGQD LKCEWELLER KAVAWLHDHA GRGTTPPPFP
     SFHLHPREPC LYVLQRTQES LWLSQLCCLR TLSLQLILHF QD