ID   VWA7_MOUSE              Reviewed;         891 AA.
AC   Q9JHA8; Q9Z1Q8;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=von Willebrand factor A domain-containing protein 7;
DE   AltName: Full=Protein G7c;
DE   Flags: Precursor;
GN   Name=Vwa7; Synonyms=D17h6s56e-3, G7c;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RX   PubMed=10803853; DOI=10.1007/s002510050634;
RA   Snoek M., Albertella M.R., van Kooij M., Wixon J., van Vugt H.,
RA   de Groot K., Campbell R.D.;
RT   "G7c, a novel gene in the mouse and human major histocompatibility complex
RT   class III region, possibly controlling lung tumor susceptibility.";
RL   Immunogenetics 51:383-386(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B10.A;
RX   PubMed=11797099; DOI=10.1007/s00251-001-0381-0;
RA   van Kooij M., de Groot K., van Vugt H., Aten J., Snoek M.;
RT   "Genotype versus phenotype: conflicting results in mapping a lung tumor
RT   susceptibility locus to the G7c recombination interval in the mouse MHC
RT   class III region.";
RL   Immunogenetics 53:656-661(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129;
RX   PubMed=14656967; DOI=10.1101/gr.1736803;
RA   Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA   Hood L.;
RT   "Analysis of the gene-dense major histocompatibility complex class III
RT   region and its comparison to mouse.";
RL   Genome Res. 13:2621-2636(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed at low level in many tissues.
CC       {ECO:0000269|PubMed:10803853}.
CC   -!- MISCELLANEOUS: Recombinatorial hotspot within the class III region.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC84152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF134319; AAF61401.1; -; mRNA.
DR   EMBL; AF134318; AAF69177.1; -; Genomic_DNA.
DR   EMBL; AF397035; AAL14453.1; -; Genomic_DNA.
DR   EMBL; AF397036; AAL14461.1; -; Genomic_DNA.
DR   EMBL; AF109905; AAC84152.1; ALT_SEQ; Genomic_DNA.
DR   CCDS; CCDS28672.1; -.
DR   RefSeq; NP_613048.1; NM_138582.1.
DR   RefSeq; XP_017172986.1; XM_017317497.1.
DR   AlphaFoldDB; Q9JHA8; -.
DR   SMR; Q9JHA8; -.
DR   STRING; 10090.ENSMUSP00000007245; -.
DR   GlyGen; Q9JHA8; 1 site.
DR   iPTMnet; Q9JHA8; -.
DR   PhosphoSitePlus; Q9JHA8; -.
DR   PaxDb; Q9JHA8; -.
DR   PRIDE; Q9JHA8; -.
DR   ProteomicsDB; 299959; -.
DR   Antibodypedia; 56596; 15 antibodies from 5 providers.
DR   Ensembl; ENSMUST00000007245; ENSMUSP00000007245; ENSMUSG00000007030.
DR   GeneID; 27762; -.
DR   KEGG; mmu:27762; -.
DR   UCSC; uc008cfa.1; mouse.
DR   CTD; 80737; -.
DR   MGI; MGI:1306798; Vwa7.
DR   VEuPathDB; HostDB:ENSMUSG00000007030; -.
DR   eggNOG; KOG4475; Eukaryota.
DR   GeneTree; ENSGT00390000011517; -.
DR   HOGENOM; CLU_013884_0_0_1; -.
DR   InParanoid; Q9JHA8; -.
DR   OMA; MEPIHYV; -.
DR   OrthoDB; 323781at2759; -.
DR   PhylomeDB; Q9JHA8; -.
DR   TreeFam; TF329905; -.
DR   BioGRID-ORCS; 27762; 3 hits in 71 CRISPR screens.
DR   PRO; PR:Q9JHA8; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q9JHA8; protein.
DR   Bgee; ENSMUSG00000007030; Expressed in lumbar dorsal root ganglion and 34 other tissues.
DR   ExpressionAtlas; Q9JHA8; baseline and differential.
DR   Genevisible; Q9JHA8; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..891
FT                   /note="von Willebrand factor A domain-containing protein 7"
FT                   /id="PRO_0000231632"
FT   DOMAIN          314..499
FT                   /note="VWFA"
FT   REGION          238..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        55
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   891 AA;  95984 MW;  1EA26B5121118720 CRC64;
     MLPVEVPLSH LGPPILLLLQ LLLPPTSAFF PNIWSLLAAP GSVTHQDLTE EAALNVTLVL
     FLEQPHPGRP RLHVEDYRGR TLLADDIFAA YFGPGFSSRR FRAALGEVSR ANAAQDFLPA
     FKSNPDLHFD AERLVQGRTR LVGALRETLV AARALEYTLA RQRLGAALHA LQDFYSHSNW
     VELGERQPHP HLLWPRQELW SLAQVGDPTC SDCEGLSCPG NMLDSTLLTS GYFGMHPPKP
     PGKCSHGGHF DQSSSQPPRG GINKDSTSPS FSPHHKLHLQ AAEVALLASI EAFSLLRSRL
     GDKAFSRLLD ITPASSLSFV LDTTGSMGEE INAAKIQARR IVEQRQGSPM EPVFYILVPF
     HDPGFGPVFT TSDPDSFWQK LNEIHALGGG DEPEMCLSAL ELALLHTPPL SDIFVFTDAS
     PKDALLTNRV ESLTRERRCR VTFLVTEDPS RTGGRRRREA LSPLRFEPYE AIARASGGEV
     IFTKDQYIQD VAAIVGESMA GLVTLPLDPP VFTPGEPCVF SVDSLLWQVT VRMHGDISSF
     WIKSPAGVSQ GPEEGIGPLG HTRRFGQFWT VTMTDPPRTG TWEIQVAAAG TPRVRVQAQT
     SLDFLFHFGI SVEDGPHPGL YPLTQPVAGL QTQLLVEVTG LTSRQKLVGG QPQFSHVVLR
     RVPEGTQLGR VSLEPVGPPV RGLLAASLPP TLLSVSSPFS LELVGQGGGG ESLRRTAPQP
     CSVAPVLLEL SGPPDFLTPG SKAPLSLHIV SFSGPQDLDL RTSVNPSFSL TSNLSRARLG
     LNESAWGRLW LEVPDSAAPD SVVMVTVTAA GQGASQVPPT HAFLRLLVLA QSSKDQLDGP
     AHSAAPVLPP VSPALLPSTL VTQGRAGGGM AGKAWWGTVG GVLFLLGCTS W