VWA7_RAT
ID VWA7_RAT Reviewed; 892 AA.
AC Q6MG64;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=von Willebrand factor A domain-containing protein 7;
DE AltName: Full=Protein G7c;
DE Flags: Precursor;
GN Name=Vwa7; Synonyms=G7c;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; BX883045; CAE83982.1; -; Genomic_DNA.
DR RefSeq; NP_997664.1; NM_212499.2.
DR RefSeq; XP_017457127.1; XM_017601638.1.
DR AlphaFoldDB; Q6MG64; -.
DR SMR; Q6MG64; -.
DR STRING; 10116.ENSRNOP00000001153; -.
DR GlyGen; Q6MG64; 1 site.
DR PaxDb; Q6MG64; -.
DR Ensembl; ENSRNOT00000001153; ENSRNOP00000001153; ENSRNOG00000000860.
DR GeneID; 309611; -.
DR KEGG; rno:309611; -.
DR UCSC; RGD:1303137; rat.
DR CTD; 80737; -.
DR RGD; 1303137; Vwa7.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT00390000011517; -.
DR HOGENOM; CLU_013884_0_0_1; -.
DR InParanoid; Q6MG64; -.
DR OMA; MEPIHYV; -.
DR OrthoDB; 323781at2759; -.
DR PhylomeDB; Q6MG64; -.
DR TreeFam; TF329905; -.
DR PRO; PR:Q6MG64; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000000860; Expressed in heart and 13 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR036465; vWFA_dom_sf.
DR SUPFAM; SSF53300; SSF53300; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..892
FT /note="von Willebrand factor A domain-containing protein 7"
FT /id="PRO_0000231633"
FT DOMAIN 313..495
FT /note="VWFA"
FT REGION 231..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 892 AA; 96045 MW; AEF5B03F05D6C92F CRC64;
MLPVEVPLSQ LGPPVLLLQL LLPPTSAFFP NIWSLLAAPG SITHQDLTEE AALNVTLELF
LEQPPPGRPH LHLEDYRGRT LLADDIFAAY FGSGFSSRRF RAALGEVSRA NAAQDFLPAS
KSNPDLHFDA ERLVQGRTRL EGALRETLVA ARALEYTLAR QRLGAALHAL QDFYSHSNWV
ELGERQPHPH LLWPRRELWS LAQVGDPTCS DCEGLSCPGN MMNLTMLTSG YFGTNPPKPP
GKCSHGGRFD QSSSQPPRGG INKDSTSPSF SPHHRLHLQA AEVALLASIE ALSLLRSRLG
TRGFSRLLDI TPASSLSFVL DTTGSMGEEI NAAKIQARRI VEQRQGSPME PVSYILVPFH
DPGFGPVFTT SDPDSFWQKL TEIHALGGGD EPEMCLSALE LALLHTPPLS DIFVFTDASP
KDAFLTNRVE SLTRERRCRV TFLVTEDPSR AQGRGRREAL SPSRFEPYEA IALASGGEVI
FTKDQHIRDV AAVVGESMAG LVTLPLEPPI FTPGEPCVFA VDSLLSKVTV RMHGDISGFW
IKSPAGLSQG PEEGIGPLGH TRRFGQFWTV TMTDPPQTGS WEIQVAAEGT PRVRVQAQTS
LDFLFHFGIS AEDGPHPGLY PLTQPVAGLQ TQLLVEVTGL VSRQKLGDGQ PQFSHAVLRR
VSEGTHLGRV SLEPVGPPER GLLAASLPPT LLSVSVPFSL ELVGQDVGGQ CLRRSAPQPC
SVAPVLLELS GPPDFLTPGS KAPLSLRVAS FSGPQDVDLR SSVNPSFSLT SNLSRARLGL
NESAWGCLWL EVPDSAAPDT VVTVTVTVTA VGQGASQVPP THAFLQLLVL AQSSKDQLED
PTHSAAPVLP PTTPALLPST LVTRGRAGRG TTGKTWWGTV GGVLFLLGCT SW