ID   VWA8_DANRE              Reviewed;        1896 AA.
AC   B0R0T1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=von Willebrand factor A domain-containing protein 8;
DE   Flags: Precursor;
GN   ORFNames=si:dkey-18l1.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Exhibits ATPase activity in vitro.
CC       {ECO:0000250|UniProtKB:Q8CC88}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:A3KMH1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8CC88}.
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DR   EMBL; BX649198; CAQ14217.1; -; Genomic_DNA.
DR   EMBL; AL929161; CAQ14217.1; JOINED; Genomic_DNA.
DR   EMBL; AL929161; CAQ14674.1; -; Genomic_DNA.
DR   EMBL; BX649198; CAQ14674.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001121810.1; NM_001128338.1.
DR   AlphaFoldDB; B0R0T1; -.
DR   STRING; 7955.ENSDARP00000102255; -.
DR   PaxDb; B0R0T1; -.
DR   PeptideAtlas; B0R0T1; -.
DR   PRIDE; B0R0T1; -.
DR   Ensembl; ENSDART00000146706; ENSDARP00000120404; ENSDARG00000078593.
DR   GeneID; 561317; -.
DR   KEGG; dre:561317; -.
DR   CTD; 23078; -.
DR   ZFIN; ZDB-GENE-070912-407; vwa8.
DR   eggNOG; KOG1808; Eukaryota.
DR   GeneTree; ENSGT00390000006601; -.
DR   HOGENOM; CLU_001400_0_0_1; -.
DR   InParanoid; B0R0T1; -.
DR   OMA; GTHIVHP; -.
DR   OrthoDB; 79800at2759; -.
DR   PhylomeDB; B0R0T1; -.
DR   PRO; PR:B0R0T1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000078593; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039891; VWA8.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR21610; PTHR21610; 1.
DR   Pfam; PF07728; AAA_5; 3.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Mitochondrion; Nucleotide-binding; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..18
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..1896
FT                   /note="von Willebrand factor A domain-containing protein 8"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000343893"
FT   DOMAIN          1705..1887
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          1536..1564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         439..446
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1896 AA;  211974 MW;  ACEA6E2174BB1FAE CRC64;
     MHSRILFKGT AAAVAARRIR HILGPLMSKE GWNCSAHEVK LLNTSSGDTV KIGEISYVLK
     TPKNPELVPV NHMMEALPQM VTQHLRWIMQ KDLLGQDVFL IGPPGPLRRS IAMQYLELTK
     REVEYVALSR DTTETDLKQR REIRSGTAFY IDQCAVRAAT EGRILVLEGL EKAERNVLPV
     LNNLLENREM QLEDGRFLMS AHRYDKLLEE HTKEELDAWK IVRVSEDFRV IALGLPVPRY
     KGNPLDPPLR SRFQARDIYY LPFKDQLEHL YRIGANVSAE RVSQLLSFAT TLCSQESASL
     SLPDFPVDNL PSALTVLNLF PMLSVQQLVQ RLYPYEAMLG KEGRTAVEGV LNRFELTDGS
     TKPSPTAVVN IEPVNGGQAE QAAVTLNITN QKITFQVPSG TRPIRPPNSS PTFINTPTHE
     RLLAEMMQSH LVKDICLIGA KGCGKSVIAR EFAEMLGYSI EPVMLYQDMT ARDLLQQRYT
     LPNGDTAWRA SPLVTAAQEG KLVLLDGIHR VNLGTLAVLS RLLHDRELDL YDGTRLLRFD
     RYQALKEELQ LTDQQLQDRS IFPIHPSFRI IALAEPPVIG STTQQWLNPE ILTMFLFHTI
     KPLAKAEETA VLQGMIPNVP GEAVEQLQHL THSLRKSNDP TALSLASSLS TRQLLRICRR
     LSQYPQESVA HAVHKACLSR FLPSLARSSL EKSLANCSIE DHPDPASEQK QLYTCTVKDG
     LLTIGNVSAP VYSPDEKMKV PDVLFYENVQ HMMVMQDMLK DFLLGEHLLL VGNQGVGKNK
     IVDRFLHLMN RPREYLQLHR DTTVQTLTLQ PSVRDGIIIY EDSPLVKAVK MGHILVIDEA
     DKAPTNVTCI LKALVESGEM ILADGRRIVS DALEAAGRPN AIPMHPDFRM IVLANRPGFP
     FLGNDFFGAL GDIFSCHAVD NPKPQAEFAM LKQYGPDVPD AVLQKLVAAF GELRAMADQG
     TITYPYSTRE VVNIVKHLQK FPDEGLANVV RNVFDFDSYN KDMREVLISA LHKHGIPIGA
     KPTSVHLAKE LPLPDCKMTG YWTISQGGNT RRKLLCPTET HRIDIKGPVF LRVQSYPSKR
     HESRSLSFTE EQAHWQIPMN EVNIVCDVTT AKDSIYVATC NPVSLYAMKE KGDSVQCIEL
     YDIFPRTISG VWQPFVSVAA LGNPLQDQVV LHEEQGNTVL HLDLVTGAVR RLILSQDKQD
     EAPRKTSNWW NSKESQPGYK MCKEFAHKNW LLFYKENGNQ LDVVDVLEGQ VHTIHLPINL
     KAVFLVAEDR WLLVESKTDR KFLLTKPMHM GAEETGVCQL HAISEDAVSS GFGNNSGMEA
     VSPQEVSSDQ LSNENLSAAL GQKIVSPNRI LCDTNTYANV IVGFPDLMSP NELYSFRRSL
     PITESRRPDM FFGSSKRTGP AKRVNCVCLL DANQVVRALP PTQVPLAEVY PKDVTPPMSA
     AYLEVTDLNS KRLKYIPVPR SNSMSPYTVW ISKVSDTDVV MAPLGSGGVV TVDMGGYVRL
     WETGLDHLQR SLLEWRNMIG SEDGRPVQIT IERDSGLDVS SPKHGKIDAK NAPHVGGNQW
     AGGTGGRDTA GLGGKGGPYR LDAGHKVYQI SQAEKDAVPD EVKRAARDMA EQAFKQRLKE
     IEMSEYDAST YDRFSGAVRR QVQSLRIILD SLQAKGKERQ WLRNQALGEL DDAKIIDGLT
     GEKSIYKRRG ELEPELGSPQ QKPKRLRVLA DVSGSMYRFN GVDGRLERSM EAVCMVMEAL
     ESYEHKFKYD ITGHSGDGFD IELVRCDKVP KNNKERLKVL KTMHAHSQFC MSGDYTLEGT
     EHAIRELAHE EADEHFVIVL SDANLERYGI SPDRFARVLT SNPQVNAFAI FIGSLGDQAD
     RLQKTLPAGR SFVAMDTKEI PQILQQIFTS TMLSSA