ID   VWC2L_DANRE             Reviewed;         223 AA.
AC   B0UZC8; B7X9K3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=von Willebrand factor C domain-containing protein 2-like;
DE   Flags: Precursor;
GN   Name=vwc2l; ORFNames=si:ch211-207d8.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=19852960; DOI=10.1016/j.febslet.2009.10.044;
RA   Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y.,
RA   Yamauchi H., Konishi M., Itoh N.;
RT   "A novel neural-specific BMP antagonist, Brorin-like, of the Chordin
RT   family.";
RL   FEBS Lett. 583:3643-3648(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May play a role in bone differentiation and matrix
CC       mineralization (By similarity). May play a role in neural development.
CC       {ECO:0000250, ECO:0000269|PubMed:19852960}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Synapse {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: At 36 hpf, expressed predominantlyin the brain,
CC       including several discrete regions in the forebrain, midbrain and
CC       hindbrain. {ECO:0000269|PubMed:19852960}.
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DR   EMBL; AB428728; BAH04287.1; -; mRNA.
DR   EMBL; CR753890; CAQ13566.1; -; Genomic_DNA.
DR   RefSeq; NP_001122036.1; NM_001128564.1.
DR   AlphaFoldDB; B0UZC8; -.
DR   STRING; 7955.ENSDARP00000115777; -.
DR   PaxDb; B0UZC8; -.
DR   Ensembl; ENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
DR   GeneID; 100148652; -.
DR   KEGG; dre:100148652; -.
DR   CTD; 402117; -.
DR   ZFIN; ZDB-GENE-081104-169; vwc2l.
DR   eggNOG; ENOG502RAAU; Eukaryota.
DR   GeneTree; ENSGT00720000108792; -.
DR   HOGENOM; CLU_100254_0_1_1; -.
DR   InParanoid; B0UZC8; -.
DR   OMA; PICKHGP; -.
DR   OrthoDB; 1478107at2759; -.
DR   PhylomeDB; B0UZC8; -.
DR   TreeFam; TF329913; -.
DR   PRO; PR:B0UZC8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000069134; Expressed in retina and 3 other tissues.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IMP:ZFIN.
DR   InterPro; IPR042979; VWC2/VWC2L.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR46252; PTHR46252; 1.
DR   SMART; SM00214; VWC; 2.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome; Repeat; Secreted; Signal;
KW   Synapse.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..223
FT                   /note="von Willebrand factor C domain-containing protein 2-
FT                   like"
FT                   /id="PRO_0000348063"
FT   DOMAIN          51..110
FT                   /note="VWFC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT   DOMAIN          114..172
FT                   /note="VWFC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
SQ   SEQUENCE   223 AA;  24509 MW;  3C34E9E9A4B43640 CRC64;
     MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG KGCVDDSGFV
     YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYRG
     KTYKILEEFK PSPCEWCRCE PNNEVHCVVA DCAVPECVNP VYEPEQCCPI CKNGPNCFAG
     TTIIPAGIEV KVDDCTICRC HSGDWWKPAQ CLRRECLNGQ ATS