VWCE_MOUSE
ID VWCE_MOUSE Reviewed; 929 AA.
AC Q3U515; E9QME6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=von Willebrand factor C and EGF domain-containing protein;
DE Flags: Precursor;
GN Name=Vwce;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May be a regulatory element in the beta-catenin signaling
CC pathway and a target for chemoprevention of hapatocellular carcinoma.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK153937; BAE32265.1; -; mRNA.
DR EMBL; AC132247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50390.1; -.
DR RefSeq; NP_082189.1; NM_027913.1.
DR AlphaFoldDB; Q3U515; -.
DR STRING; 10090.ENSMUSP00000056958; -.
DR GlyGen; Q3U515; 3 sites.
DR iPTMnet; Q3U515; -.
DR PhosphoSitePlus; Q3U515; -.
DR MaxQB; Q3U515; -.
DR PaxDb; Q3U515; -.
DR PRIDE; Q3U515; -.
DR ProteomicsDB; 297837; -.
DR Antibodypedia; 52915; 108 antibodies from 17 providers.
DR Ensembl; ENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
DR GeneID; 71768; -.
DR KEGG; mmu:71768; -.
DR UCSC; uc008gqo.2; mouse.
DR CTD; 220001; -.
DR MGI; MGI:1919018; Vwce.
DR VEuPathDB; HostDB:ENSMUSG00000043789; -.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000161089; -.
DR HOGENOM; CLU_013313_1_0_1; -.
DR InParanoid; Q3U515; -.
DR OMA; PLCTGCF; -.
DR OrthoDB; 1223914at2759; -.
DR PhylomeDB; Q3U515; -.
DR TreeFam; TF330819; -.
DR BioGRID-ORCS; 71768; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Vwce; mouse.
DR PRO; PR:Q3U515; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q3U515; protein.
DR Bgee; ENSMUSG00000043789; Expressed in metanephric proximal tubule and 60 other tissues.
DR ExpressionAtlas; Q3U515; baseline and differential.
DR Genevisible; Q3U515; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0098586; P:cellular response to virus; IBA:GO_Central.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 4.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..929
FT /note="von Willebrand factor C and EGF domain-containing
FT protein"
FT /id="PRO_0000318581"
FT DOMAIN 70..98
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 142..180
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 181..219
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 220..262
FT /note="EGF-like 4; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 376..433
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 433..494
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 491..552
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 558..618
FT /note="VWFC 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 619..677
FT /note="VWFC 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 677..762
FT /note="VWFC 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT REGION 291..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 454
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 464
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 787
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 146..155
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 151..164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 166..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 185..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 190..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 205..218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 224..237
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 233..246
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 248..261
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CONFLICT 344
FT /note="L -> P (in Ref. 1; BAE32265)"
FT /evidence="ECO:0000305"
FT CONFLICT 375
FT /note="S -> P (in Ref. 1; BAE32265)"
FT /evidence="ECO:0000305"
FT CONFLICT 777
FT /note="V -> I (in Ref. 1; BAE32265)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 929 AA; 97668 MW; EDE1A8EA0272E119 CRC64;
MWARLLLHVA YILIPLLGSS ARGYTGRKAP GHYSAERRRL GPHVCLSGFG SGCCPGWAPS
MGSGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPEA HGSCGEYGCD LTCNHGGCQE
VARVCPVGFL MTETAVGIRC ADIDECLSSS CEGHCVNTEG GFVCECGPGM QLSADRHSCQ
DTDECLGTPC QQRCKNSIGS YKCSCRAGFH LHGNRHSCID VNECRRPQER RVCHHTCHNT
VGSFLCTCRP GFRLRSDRVS CEAFPKAVLA PSAILQPRQH PAKMSLLLPE AGRPALSPGH
SPPPGAPGYP TGVRTISQPS TTQVLPTFFP TQLISTPVPS SSPLGTLGPP SLLQGAVGTP
SSPRGPESPK LGAGSSSCWH LGATYESGSR WNQPGCSQCL CQDGEVTCGG VRCDATCSHP
VPPRDGGCCP SCTGCFHSGA IRAEGDVFSP PEENCTVCVC LAGNVSCISP ECPPGPCKAS
PQSDCCTCVP GRCYFHGRWY TDGAVFSGGG DDCTTCVCQN GEVECSFTPC PELECPREEW
LLGPGQCCFT CREPTPTTGC SLDDNGVEFP IGQIWSPGDP CELCVCQADG SVSCKRTDCV
DSCPHPIRIP GQCCPDCSAG CTYTGRIFYN NETFPSVLDP CLSCICLLGS VACSPVDCPI
TCTYPFHPDG ECCPVCHDCN FEGRKVVNGQ VFTLDDEPCT RCICQLGEVS CETVPCRPIC
TDPSCPDSVF PLEEKQQPSP HGELAKAARN ARGDTEVPVN CSSCPGPPSA SPTRPMVHLL
QRLLRTNLSN IQSASPSPPI AQTSSSPLLE PEGISLGKPR ASQPPEPSAG SPVSPRLSTL
PPAIPGTPLS PVTPESSSST FGTQTAFQWL LSATPLTEAE TPSMTNADLS ETLTTSSSSQ
RLSAALPDTP NPVPQQSTID TPKKENSTI
