ID   VWDE_MOUSE              Reviewed;         926 AA.
AC   Q6DFV8; B9EKY3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=von Willebrand factor D and EGF domain-containing protein;
DE   Flags: Precursor;
GN   Name=Vwde; Synonyms=Gm467;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Head;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- CAUTION: Despite its name, this protein does not contain any EGF-like
CC       domains. The human ortholog has a much longer C-terminus which contains
CC       a number of EGF-like domains but there is currently no evidence for
CC       this region in mouse. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH76621.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH76621.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH76621.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BC076621; AAH76621.1; ALT_SEQ; mRNA.
DR   EMBL; BC151200; AAI51201.1; -; mRNA.
DR   CCDS; CCDS51722.1; -.
DR   RefSeq; NP_001013779.2; NM_001013757.2.
DR   AlphaFoldDB; Q6DFV8; -.
DR   SMR; Q6DFV8; -.
DR   STRING; 10090.ENSMUSP00000058110; -.
DR   PhosphoSitePlus; Q6DFV8; -.
DR   PaxDb; Q6DFV8; -.
DR   PRIDE; Q6DFV8; -.
DR   Ensembl; ENSMUST00000054530; ENSMUSP00000058110; ENSMUSG00000079679.
DR   GeneID; 232585; -.
DR   UCSC; uc009ayl.2; mouse.
DR   CTD; 221806; -.
DR   MGI; MGI:2685313; Vwde.
DR   VEuPathDB; HostDB:ENSMUSG00000079679; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00940000163868; -.
DR   HOGENOM; CLU_329721_0_0_1; -.
DR   InParanoid; Q6DFV8; -.
DR   OrthoDB; 576103at2759; -.
DR   PhylomeDB; Q6DFV8; -.
DR   TreeFam; TF331567; -.
DR   BioGRID-ORCS; 232585; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Vwde; mouse.
DR   PRO; PR:Q6DFV8; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q6DFV8; protein.
DR   Bgee; ENSMUSG00000079679; Expressed in animal zygote and 11 other tissues.
DR   ExpressionAtlas; Q6DFV8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00216; VWD; 1.
DR   PROSITE; PS51233; VWFD; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..926
FT                   /note="von Willebrand factor D and EGF domain-containing
FT                   protein"
FT                   /id="PRO_0000329442"
FT   DOMAIN          429..612
FT                   /note="VWFD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        431..572
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        474..483
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
SQ   SEQUENCE   926 AA;  103786 MW;  431E6B5209C7B9DF CRC64;
     MRGGAWARLV TALMLLVQGK CQQAQECSPG GHRILQSPYR SVHFDSVYLQ YSAVQDLICD
     HSLSPGWYRF LIFDRPAEMP TKCVEMNHCG TQAPIWLSLS DSEALPLPGE MKKLTACATW
     QFLFSTEKDC CLFQIPVSVR NCGDFFVYLL QPTQGCMGYC AEAISDVKLH TCGPGETENE
     GGCVGQLSMA QPPAPPAPPG RPKISVELLG SLVFCRCTFD VSPTNTSVGF LIAWSRLSSQ
     EIKEELRQES TLQAFSLLEL DGINLRLGDT IFCSAAVFYL EKPDVQSIAV ESQEFFAGIK
     LKPELDTISE DGKEYQLKIE STIPIVCSEF SELDQGCKIS LKLKTIEQGK EHLGLNLALS
     SCHVDLHQNS CANGICSQAV LYYTAVTDFS RDGDRVTDII VEPIVNDVFL WDRYAPDSIQ
     IKVKDVPSAY CYSFTDPHII TFDGRVYDNF KTGTFVLYKS MSRDFEIHVR QWNCGSLHYS
     VSCNCGFVAK EEGDIVTFDM CSGQLHESPS YLFVKNQESS SSNIRITESY LGRKITIWFS
     SGAFIRADLS EWGMSITLRV PSLDYRSTLG LCGTFDENPE NDFHDKNGIK IDHDDNYIAF
     INEWRLQPGR SMFDKVPASS RFPAKPSYCS CWLGTAMHHL LSHHLDSRSH LEMASGCKGI
     KHLQFSSLIP DLDITSEYIN SEALAGKLSP HVPREENNLN FLLQKNAHPN LSKLDLNLPH
     PGNKILNPPA YLSDERHTQD QEMRKSLQNR WKRQNVKDFH PVYIFQSLGQ GNLEEFSYFF
     PEDHTEDSQP EFAPSWPTAS GLTEFSVLAI CQQTLANSSI GRLCLPFLGR TLNHVVDMCV
     KDVLLKDDVN WAEGGVALLE NECERRVLED GKRNVEENRK TVEGILEVLK CPNLCSGHGE
     CMGWGCVCSP GYSSYDCSHS YGMQML