ID   VXCL1_RCMVE             Reviewed;         115 AA.
AC   K7XWG4;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   29-SEP-2021, entry version 30.
DE   RecName: Full=Viral Lymphotactin;
DE   AltName: Full=Viral XCL1;
DE            Short=vSCL1;
DE   Flags: Precursor;
GN   Name=vXCL1; ORFNames=e156.5;
OS   Rat cytomegalovirus (isolate England) (RCMV-E) (Murid herpesvirus 8).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=1261657;
OH   NCBI_TaxID=10116; Rattus norvegicus (Rat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=England;
RX   PubMed=23166247; DOI=10.1128/jvi.02614-12;
RA   Ettinger J., Geyer H., Nitsche A., Zimmermann A., Brune W., Sandford G.R.,
RA   Hayward G.S., Voigt S.;
RT   "Complete genome sequence of the english isolate of rat cytomegalovirus
RT   (Murid herpesvirus 8).";
RL   J. Virol. 86:13838-13838(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=England;
RX   PubMed=26209537; DOI=10.1099/vir.0.000109;
RA   Geyer H., Ettinger J., Moller L., Schmolz E., Nitsche A., Brune W.,
RA   Heaggans S., Sandford G., Hayward G.S., Voigt S.;
RT   "The English isolate and a newly identified Berlin isolate of Rat
RT   Cytomegalovirus (RCMV) share similarities with but separate as an anciently
RT   diverged clade from Mouse CMV and the Maastricht isolate of RCMV.";
RL   J. Gen. Virol. 96:1873-1882(2015).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST XCR1.
RC   STRAIN=England;
RX   PubMed=24155383; DOI=10.1128/jvi.02330-13;
RA   Geyer H., Hartung E., Mages H.W., Weise C., Beluzic R., Vugrek O.,
RA   Jonjic S., Kroczek R.A., Voigt S.;
RT   "Cytomegalovirus expresses the chemokine homologue vXCL1 capable of
RT   attracting XCR1+ CD4- dendritic cells.";
RL   J. Virol. 88:292-302(2014).
CC   -!- FUNCTION: Chemoattractant for CD4-dendritic cells, but not for CD4+
CC       dendritic cells, T-cells or B-cells. {ECO:0000269|PubMed:24155383}.
CC   -!- SUBUNIT: Interacts with host XCR1. {ECO:0000303|PubMed:24155383}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24155383}.
CC   -!- PTM: N-glycosylated and O-glycosylated. {ECO:0000269|PubMed:24155383}.
CC   -!- SIMILARITY: Belongs to the intercrine gamma family.
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DR   EMBL; JX867617; AFX83458.1; -; Genomic_DNA.
DR   RefSeq; YP_007016541.1; NC_019559.1.
DR   SMR; K7XWG4; -.
DR   GeneID; 14039064; -.
DR   KEGG; vg:14039064; -.
DR   Proteomes; UP000127637; Genome.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR008105; Chemokine_XCL1/XCL2.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   PANTHER; PTHR12015:SF101; PTHR12015:SF101; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR01731; LYMPHOTACTIN.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Host-virus interaction;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:24155383"
FT   CHAIN           20..115
FT                   /note="Viral Lymphotactin"
FT                   /id="PRO_0000434598"
FT   DISULFID        30..67
FT                   /evidence="ECO:0000250|UniProtKB:P47992"
SQ   SEQUENCE   115 AA;  12819 MW;  26387F785A897ECC CRC64;
     MRLLTILALC CVAIWVVESI GIEVLHETIC VSLRTQRIPI QKIKTYTIKE GAMRAVIFVT
     KRGLRICADP DAGWTKAAIT TLDKKNKKNK QKFNTTTVIP TQVPVSTNET TTVYG