ID   VXIS_BPHK0              Reviewed;          72 AA.
AC   P68927; P11683; P16408;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   29-SEP-2021, entry version 66.
DE   RecName: Full=Excisionase;
GN   Name=xis;
OS   Escherichia phage HK022 (Bacteriophage HK022).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Hendrixvirinae; Shamshuipovirus.
OX   NCBI_TaxID=10742;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2547971; DOI=10.1016/0022-2836(89)90238-6;
RA   Yagil E., Dolev S., Oberto J., Kislev N., Ramaiah N., Weisberg R.A.;
RT   "Determinants of site-specific recombination in the lambdoid coliphage
RT   HK022. An evolutionary change in specificity.";
RL   J. Mol. Biol. 207:695-717(1989).
RN   [2]
RP   STRUCTURE BY NMR OF MUTANT SER-28.
RX   PubMed=14653811; DOI=10.1111/j.1432-1033.2003.03884.x;
RA   Rogov V.V., Luecke C., Muresanu L., Wienk H., Kleinhaus I., Werner K.,
RA   Loehr F., Pristovsek P., Rueterjans H.;
RT   "Solution structure and stability of the full-length excisionase from
RT   bacteriophage HK022.";
RL   Eur. J. Biochem. 270:4846-4858(2003).
CC   -!- FUNCTION: Excisionase and integrase are necessary for the excision of
CC       prophage from the host genome by site-specific recombination at the att
CC       site.
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DR   EMBL; X51962; CAA36222.1; -; Genomic_DNA.
DR   PIR; S06533; S06533.
DR   RefSeq; NP_037687.1; NC_002166.1.
DR   PDB; 1PM6; NMR; -; A=1-72.
DR   PDBsum; 1PM6; -.
DR   BMRB; P68927; -.
DR   SMR; P68927; -.
DR   GeneID; 1262493; -.
DR   KEGG; vg:1262493; -.
DR   EvolutionaryTrace; P68927; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032359; P:provirus excision; IEA:UniProtKB-KW.
DR   DisProt; DP01013; -.
DR   Gene3D; 1.10.1660.20; -; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR012884; Excisionase-like.
DR   InterPro; IPR038137; Excisionase-like_sf.
DR   Pfam; PF07825; Exc; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA recombination; DNA-binding; Viral genome excision.
FT   CHAIN           1..72
FT                   /note="Excisionase"
FT                   /id="PRO_0000077712"
FT   STRAND          2..4
FT                   /evidence="ECO:0007829|PDB:1PM6"
FT   HELIX           5..11
FT                   /evidence="ECO:0007829|PDB:1PM6"
FT   STRAND          12..14
FT                   /evidence="ECO:0007829|PDB:1PM6"
FT   HELIX           18..27
FT                   /evidence="ECO:0007829|PDB:1PM6"
FT   STRAND          30..32
FT                   /evidence="ECO:0007829|PDB:1PM6"
FT   STRAND          38..44
FT                   /evidence="ECO:0007829|PDB:1PM6"
FT   STRAND          48..51
FT                   /evidence="ECO:0007829|PDB:1PM6"
SQ   SEQUENCE   72 AA;  8635 MW;  0E6A4843503344AA CRC64;
     MYLTLQEWNA RQRRPRSLET VRRWVRECRI FPPPVKDGRE YLFHESAVKV DLNRPVTGSL
     LKRIRNGKKA KS