V_MUMPM
ID V_MUMPM Reviewed; 224 AA.
AC P30928; Q783W0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Non-structural protein V;
DE AltName: Full=Non-structural protein NS1;
GN Name=P/V;
OS Mumps virus (strain Miyahara vaccine) (MuV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC Orthorubulavirus; Mumps orthorubulavirus.
OX NCBI_TaxID=11171;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3404121; DOI=10.1099/0022-1317-69-8-2043;
RA Takeuchi K., Hishiyama M., Yamada A., Sugiura A.;
RT "Molecular cloning and sequence analysis of the mumps virus gene encoding
RT the P protein: mumps virus P gene is monocistronic.";
RL J. Gen. Virol. 69:2043-2049(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND RNA EDITING.
RX PubMed=2389552; DOI=10.1016/0042-6822(90)90400-l;
RA Takeuchi K., Tanabayashi K., Hishiyama M., Yamada Y.K., Yamada A.,
RA Sugiura A.;
RT "Detection and characterization of mumps virus V protein.";
RL Virology 178:247-253(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1585659; DOI=10.1016/0042-6822(92)90555-4;
RA Okazaki K., Tanabayashi K., Takeuchi K., Hishiyama M., Okazaki K.,
RA Yamada A.;
RT "Molecular cloning and sequence analysis of the mumps virus gene encoding
RT the L protein and the trailer sequence.";
RL Virology 188:926-930(1992).
RN [4]
RP FUNCTION, AND INTERACTION WITH HOST STAT1; STAT2; STAT3; DDB1 AND CUL4A.
RC STRAIN=Enders;
RX PubMed=12743296; DOI=10.1128/jvi.77.11.6385-6393.2003;
RA Ulane C.M., Rodriguez J.J., Parisien J.P., Horvath C.M.;
RT "STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and
RT oncogene signaling.";
RL J. Virol. 77:6385-6393(2003).
RN [5]
RP FUNCTION.
RC STRAIN=RW;
RX PubMed=15767445; DOI=10.1128/jvi.79.7.4451-4459.2005;
RA Kubota T., Yokosawa N., Yokota S., Fujii N., Tashiro M., Kato A.;
RT "Mumps virus V protein antagonizes interferon without the complete
RT degradation of STAT1.";
RL J. Virol. 79:4451-4459(2005).
CC -!- FUNCTION: Plays an essential role in the inhibition of host immune
CC response. Prevents the establishment of cellular antiviral state by
CC blocking interferon-alpha/beta (IFN-alpha/beta) production and
CC signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to
CC inhibit the transduction pathway involved in the activation of IFN-beta
CC promoter, thus protecting the virus against cell antiviral state.
CC Blocks the type I and II interferon signaling pathways by interacting
CC with host STAT1, STAT2 and STAT3, and mediating their ubiquitination
CC and subsequent proteasomal degradation. {ECO:0000269|PubMed:12743296,
CC ECO:0000269|PubMed:15767445}.
CC -!- SUBUNIT: Interacts with host IFIH1/MDA5 and DHX58/LGP2. Forms with host
CC DDB1, CUL4A, STAT1, STAT2 and STAT3 the mumps virus V-dependent complex
CC (VDC). {ECO:0000269|PubMed:12743296}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=155 {ECO:0000269|PubMed:2389552};
CC Note=Partially edited. RNA editing at this position consists of an
CC insertion of two guanine nucleotides. The sequence displayed here is
CC the V protein, derived from the unedited RNA. The edited RNA gives rise
CC to the P protein (AC P16595).;
CC -!- SIMILARITY: Belongs to the paramyxoviruses V protein family.
CC {ECO:0000305}.
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DR EMBL; D00352; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AB040874; BAA94386.1; -; Genomic_RNA.
DR PIR; A46343; A46343.
DR SMR; P30928; -.
DR Proteomes; UP000002331; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; IEA:UniProtKB-KW.
DR GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039554; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity; IEA:UniProtKB-KW.
DR InterPro; IPR024279; Paramyx_V_Zn-bd.
DR Pfam; PF13008; zf-Paramyx-P; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus;
KW Inhibition of host MDA5 by virus; Inhibition of host RLR pathway by virus;
KW Inhibition of host STAT1 by virus; Inhibition of host STAT2 by virus;
KW Interferon antiviral system evasion; Metal-binding; Reference proteome;
KW RNA editing; Viral immunoevasion; Zinc.
FT CHAIN 1..224
FT /note="Non-structural protein V"
FT /id="PRO_0000142820"
FT REGION 55..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 170
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 189
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 193
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 205
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 207
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 210
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 214
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 217
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
SQ SEQUENCE 224 AA; 24133 MW; C680C844616D6EA3 CRC64;
MDQFIKQDET GDLIETGMNV ANHFLSAPIQ GTNSLSKATI IPGVAPVLIG NPEQKNIQYP
TTSHQGSKSK GRGSGARPII VSSSEGGTGG TQVPEPLFAQ TGQGGIVTTV YQDPTIQPTG
SYRSVELAKI GKERMINRFV EKPRTSTPVT EFKRGAGSGC SRPDNPRGGH RREWSLSWVQ
GEVRVFEWCN PICSPITAAA RFHSCKCGNC PAKCDQCERD YGPP
