ID   V_PI4HB                 Reviewed;         229 AA.
AC   P21740;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Non-structural protein V;
GN   Name=P/V;
OS   Human parainfluenza 4b virus (strain 68-333) (HPIV-4b).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Human orthorubulavirus 4.
OX   NCBI_TaxID=11227;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND RNA EDITING.
RX   PubMed=2167560; DOI=10.1016/0042-6822(90)90413-l;
RA   Kondo K., Bando H., Tsurudome M., Kawano M., Nishio M., Ito Y.;
RT   "Sequence analysis of the phosphoprotein (P) genes of human parainfluenza
RT   type 4A and 4B viruses and RNA editing at transcript of the P genes: the
RT   number of G residues added is imprecise.";
RL   Virology 178:321-326(1990).
CC   -!- FUNCTION: Blocks host interferon signaling. {ECO:0000250}.
CC   -!- RNA EDITING: Modified_positions=153 {ECO:0000269|PubMed:2167560};
CC       Note=Partially edited. RNA editing at this position consists of an
CC       insertion of two guanine nucleotides. The sequence displayed here is
CC       the V protein, derived from the unedited RNA. The edited RNA gives rise
CC       to the P protein (AC P21738).;
CC   -!- SIMILARITY: Belongs to the paramyxoviruses V protein family.
CC       {ECO:0000305}.
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DR   EMBL; M55976; AAA46807.1; -; Genomic_RNA.
DR   PIR; D43685; D43685.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039554; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity; IEA:UniProtKB-KW.
DR   InterPro; IPR024279; Paramyx_V_Zn-bd.
DR   Pfam; PF13008; zf-Paramyx-P; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host MDA5 by virus; Inhibition of host RLR pathway by virus;
KW   Inhibition of host STAT1 by virus; Interferon antiviral system evasion;
KW   Metal-binding; RNA editing; Viral immunoevasion; Zinc.
FT   CHAIN           1..229
FT                   /note="Non-structural protein V"
FT                   /id="PRO_0000142818"
FT   REGION          28..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..115
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         178
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         197
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         201
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         213
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         215
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         218
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         222
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  25566 MW;  DE1899053A17E40E CRC64;
     MSFEISVEEI DELIETGNLN IDYALKELGA TSQPPPNRPL SQISKTEENN DETRTSKNSA
     SAEAPAHASS PLRSHNEESE PGKQSSDGFS MISNRPQTGM LLMGSDTQSP SPSKTYQGLI
     LDAKKRALNE PRRNQKTTNE HGNTNDTWIF KRGEYSHQER GLGYTESEIK NTIFIPRHRR
     EHSISWVNGR TTISEWCNPC CAPVKSIASV EKCTCGRCPK ICELCIRDP