ID   V_TPMV                  Reviewed;         282 AA.
AC   Q9QM81;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Non-structural protein V;
GN   Name=P/V;
OS   Tupaia paramyxovirus (TPMV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Narmovirus; Tupaia narmovirus.
OX   NCBI_TaxID=92129;
OH   NCBI_TaxID=37347; Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND RNA EDITING.
RX   PubMed=10366580; DOI=10.1006/viro.1999.9693;
RA   Tidona C.A., Kurz H.W., Gelderblom H.R., Darai G.;
RT   "Isolation and molecular characterization of a novel cytopathogenic
RT   paramyxovirus from tree shrews.";
RL   Virology 258:425-434(1999).
CC   -!- FUNCTION: Blocks host interferon signaling. {ECO:0000250}.
CC   -!- RNA EDITING: Modified_positions=229 {ECO:0000269|PubMed:10366580};
CC       Note=Partially edited. RNA editing at this position consists of an
CC       insertion of one guanine nucleotide. The sequence displayed here is the
CC       V protein, derived from the unedited RNA. The edited RNA gives rise to
CC       the P protein (AC Q9WS39).;
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DR   EMBL; AF079780; AAD28696.2; -; Genomic_RNA.
DR   RefSeq; NP_054692.1; NC_002199.1.
DR   SMR; Q9QM81; -.
DR   GeneID; 1452636; -.
DR   Proteomes; UP000136220; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039554; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity; IEA:UniProtKB-KW.
DR   InterPro; IPR024279; Paramyx_V_Zn-bd.
DR   Pfam; PF13008; zf-Paramyx-P; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host MDA5 by virus; Inhibition of host RLR pathway by virus;
KW   Interferon antiviral system evasion; Metal-binding; Reference proteome;
KW   RNA editing; Viral immunoevasion; Zinc.
FT   CHAIN           1..282
FT                   /note="Non-structural protein V"
FT                   /id="PRO_0000142832"
FT   REGION          29..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         230
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         249
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         253
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         267
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         270
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         274
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         277
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30704 MW;  573E3E4C95DF40FC CRC64;
     MNNTEIIENA SKVLEAIDAA KEEELRNLNS LVQPRAPLNA GSTPGEIINE IKHLSTRDQE
     GGTSSKDEEE SGAGRTVAEG AATRDHKYSK SRPKKQPRSG LQSGAAGKNP TPDGEGGDTC
     NRELDQHSDG DGHSNTEGAS SDLASIQPCQ TDDAPCSSTS YLDEEDEPAV RPKTQCKQSG
     LIESKEDEDG MLSELHEQHK GRSKRLSALG RVNSSPIPSP RPDELLKKGH RREYSMVWSN
     DGVFIESWCN PMCARIRPLP IREICVCGRC PLKCSKCLLD PE