ID   W4937_FUSPC             Reviewed;         500 AA.
AC   K3VAW8;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Probable transcription factor FPSE_09189 {ECO:0000303|PubMed:25412204};
DE   AltName: Full=W493 A and B biosynthesis cluster protein FPSE_09189 {ECO:0000303|PubMed:25412204};
GN   ORFNames=FPSE_09189;
OS   Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=1028729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CS3096;
RX   PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA   Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA   Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT   "Comparative pathogenomics reveals horizontally acquired novel virulence
RT   genes in fungi infecting cereal hosts.";
RL   PLoS Pathog. 8:E1002952-E1002952(2012).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=25412204; DOI=10.1021/np500436r;
RA   Soerensen J.L., Sondergaard T.E., Covarelli L., Fuertes P.R., Hansen F.T.,
RA   Frandsen R.J., Saei W., Lukassen M.B., Wimmer R., Nielsen K.F.,
RA   Gardiner D.M., Giese H.;
RT   "Identification of the biosynthetic gene clusters for the lipopeptides
RT   fusaristatin A and W493 B in Fusarium graminearum and F.
RT   pseudograminearum.";
RL   J. Nat. Prod. 77:2619-2625(2014).
CC   -!- FUNCTION: The two putative transcription factors FPSE_09188 and
CC       FPSE_09189 could be responsible for orchestrating expression of the
CC       W493 A and B biosynthesis cluster genes (Probable). W493 A and B
CC       consist of six amino acid residues D-allo-thr, L-Ala, D-Ala, L-Gln, D-
CC       Tyr, and L-Val/L-Ile linked to a 3-hydroxy-4-methyltetradecanoic acid
CC       polyketide chain (PubMed:25412204). {ECO:0000269|PubMed:25412204,
CC       ECO:0000305|PubMed:25412204}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25412204}.
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DR   EMBL; AFNW01000306; EKJ70679.1; -; Genomic_DNA.
DR   RefSeq; XP_009260581.1; XM_009262306.1.
DR   AlphaFoldDB; K3VAW8; -.
DR   SMR; K3VAW8; -.
DR   STRING; 101028.EKJ70679; -.
DR   EnsemblFungi; EKJ70679; EKJ70679; FPSE_09189.
DR   GeneID; 20367806; -.
DR   KEGG; fpu:FPSE_09189; -.
DR   eggNOG; ENOG502QQ9D; Eukaryota.
DR   HOGENOM; CLU_033363_1_0_1; -.
DR   InParanoid; K3VAW8; -.
DR   Proteomes; UP000007978; Chromosome 1.
DR   Proteomes; UP000007978; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.910.10; -; 1.
DR   InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR   SUPFAM; SSF48613; SSF48613; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..500
FT                   /note="Probable transcription factor FPSE_09189"
FT                   /id="PRO_0000445373"
FT   REGION          161..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..474
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   500 AA;  55684 MW;  3BAE8BF3566A298B CRC64;
     MPRPADTYTH DQGHLQNCPE YVAWRVAGNG QELAPTNPYN ATGRRAFADS YGFDNSNLDL
     RPDQEVPTMQ RIRSTLDMSK YFDEFFDDSL DHKCARVRCR SCGFVRAKNA TRQADHLTQC
     KDFLATDEGE ELMASGSLVH NVQQHQPPAI WNGARPHPDL MVRHLSNHPP SGTVPVGPCS
     RPEPSRASQR PEPPSLAQHL LDQSDDLLTN AVQHSFLAHA GSGSLSENDF NQWLAQIGYI
     SRSLVPFTGA LIGKIRIPET GNLEHDSTFR CLDLLCSAVT NMKKELEFLE ATKREYGLEV
     GLDEPRPATK SFIDLFNSAS CASATLLEGM VLLWAVEILF YNSFSYAGSF VAQPMPTQER
     SSFSLPSYSL PSSASPGAYS GQTIRKDRHT TALREAFIKN WKSENFSQFV DVCKSIVDEL
     AMDQMTGNGR ADTSACERVF NQAVWLWAQV FPQTTGIRTG HEDSSRDGGR ENKAMNRNRS
     TGNSVEIEDE YNVQTSTQLE