ID   CAMKV_DANRE             Reviewed;         436 AA.
AC   Q7SY49; Q1LXP6; Q6STH4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=CaM kinase-like vesicle-associated protein;
DE   AltName: Full=1G5z;
GN   Name=camkv; ORFNames=zgc:63506;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AB;
RA   Lim H., Ro H., Won M., Rhee M.;
RT   "1G5z, a zebrafish homolog of rat 1G5 is expressed in the brain and sensory
RT   neurons.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Does not appear to have detectable kinase activity.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Interacts with calmodulin, in the presence of calcium.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane
CC       protein. Note=May be associated with vesicular structures.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AY450361; AAR20249.1; -; mRNA.
DR   EMBL; BX296566; CAK04329.1; -; Genomic_DNA.
DR   EMBL; BC055127; AAH55127.1; -; mRNA.
DR   RefSeq; NP_956744.1; NM_200450.1.
DR   AlphaFoldDB; Q7SY49; -.
DR   SMR; Q7SY49; -.
DR   STRING; 7955.ENSDARP00000108125; -.
DR   PaxDb; Q7SY49; -.
DR   PRIDE; Q7SY49; -.
DR   Ensembl; ENSDART00000125766; ENSDARP00000108125; ENSDARG00000005141.
DR   Ensembl; ENSDART00000188113; ENSDARP00000155987; ENSDARG00000117013.
DR   GeneID; 393422; -.
DR   KEGG; dre:393422; -.
DR   CTD; 393422; -.
DR   ZFIN; ZDB-GENE-040426-1140; camkvb.
DR   eggNOG; KOG0032; Eukaryota.
DR   GeneTree; ENSGT00940000156468; -.
DR   HOGENOM; CLU_000288_63_0_1; -.
DR   InParanoid; Q7SY49; -.
DR   OMA; PREMPWI; -.
DR   OrthoDB; 330091at2759; -.
DR   PhylomeDB; Q7SY49; -.
DR   TreeFam; TF314166; -.
DR   PRO; PR:Q7SY49; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000005141; Expressed in brain and 4 other tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IBA:GO_Central.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding; Cytoplasmic vesicle; Membrane; Reference proteome.
FT   CHAIN           1..436
FT                   /note="CaM kinase-like vesicle-associated protein"
FT                   /id="PRO_0000250097"
FT   DOMAIN          24..286
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          328..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..436
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        76
FT                   /note="M -> V (in Ref. 1; AAR20249)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        268
FT                   /note="E -> G (in Ref. 1; AAR20249)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        326
FT                   /note="L -> H (in Ref. 1; AAR20249)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        426
FT                   /note="S -> P (in Ref. 3; AAH55127)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   436 AA;  48694 MW;  ECC823512948A3EE CRC64;
     MPFGCLKPGE KKDYNSPTEI TDKYDLGQIV KSEEFCEIFR AKDKNTLKMY TCKKFLKKDG
     RKVRKAAKNE IVILKMVKHP NILQLVDVYE TRKEYYLFLE LATGREVFDW ILDQGYYSER
     DTSNVIRQVM EAVAYLHSLK IVHRNLKLEN LVYYNRLKHS KIVISDFHLA KLENGLIKEP
     CGTPEYLAPE VVGRQRYGRP VDCWALGVIM YILLSGNPPF YDEADDDDYE NHDKNLFRKI
     LAGDYEFDSP YWDEISDSAK NLVSRLMEVD QDQRLTAQEA INHEWISGNA ASDKNIKENV
     CAQIEKNFAK AKWKKAVRVT TMMKRLRAPE NQTAAATAPA AEAAAASPSE ADPAAGAQET
     PQAASEASTA PSSTAESLSA SIEVPAVEPA NAEAASAAVQ PPAEPVVHVP EPEQPVPTSR
     CNGEASALDT VEEQSG