CAMKV_HUMAN
ID CAMKV_HUMAN Reviewed; 501 AA.
AC Q8NCB2; A6NFD4; Q6FIB8; Q8NBS8; Q8NC85; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=CaM kinase-like vesicle-associated protein;
GN Name=CAMKV;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Retinoblastoma, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-491.
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP VARIANTS [LARGE SCALE ANALYSIS] TRP-40; SER-60; TRP-274; ASP-279 AND
RP LEU-472.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
CC -!- FUNCTION: Does not appear to have detectable kinase activity.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC -!- SUBUNIT: Interacts with calmodulin, in the presence of calcium.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Note=Predominantly observed
CC in association with the plasma membrane of soma and in neurites, both
CC axons and dendrites. May be associated with vesicular structures (By
CC similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NCB2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCB2-2; Sequence=VSP_020600;
CC Name=3;
CC IsoId=Q8NCB2-3; Sequence=VSP_020601;
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AK074856; BAC11248.1; -; mRNA.
DR EMBL; AK074899; BAC11278.1; -; mRNA.
DR EMBL; AK075294; BAC11528.1; -; mRNA.
DR EMBL; AL136697; CAB66632.1; -; mRNA.
DR EMBL; CR533508; CAG38539.1; -; mRNA.
DR EMBL; AL833943; CAD38798.2; -; Transcribed_RNA.
DR EMBL; AC105935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW65027.1; -; Genomic_DNA.
DR EMBL; BC000497; AAH00497.1; -; mRNA.
DR EMBL; BC001921; AAH01921.1; -; mRNA.
DR EMBL; BC005828; AAH05828.1; -; mRNA.
DR EMBL; BC017363; AAH17363.1; -; mRNA.
DR EMBL; BC019256; AAH19256.1; -; mRNA.
DR CCDS; CCDS33762.1; -. [Q8NCB2-1]
DR CCDS; CCDS82776.1; -. [Q8NCB2-3]
DR RefSeq; NP_001307076.1; NM_001320147.1. [Q8NCB2-3]
DR RefSeq; NP_076951.2; NM_024046.4. [Q8NCB2-1]
DR AlphaFoldDB; Q8NCB2; -.
DR SMR; Q8NCB2; -.
DR BioGRID; 122482; 84.
DR IntAct; Q8NCB2; 86.
DR STRING; 9606.ENSP00000419195; -.
DR GlyGen; Q8NCB2; 4 sites, 1 O-linked glycan (4 sites).
DR iPTMnet; Q8NCB2; -.
DR PhosphoSitePlus; Q8NCB2; -.
DR SwissPalm; Q8NCB2; -.
DR BioMuta; CAMKV; -.
DR DMDM; 115311319; -.
DR EPD; Q8NCB2; -.
DR jPOST; Q8NCB2; -.
DR MassIVE; Q8NCB2; -.
DR MaxQB; Q8NCB2; -.
DR PaxDb; Q8NCB2; -.
DR PeptideAtlas; Q8NCB2; -.
DR PRIDE; Q8NCB2; -.
DR ProteomicsDB; 72868; -. [Q8NCB2-1]
DR ProteomicsDB; 72869; -. [Q8NCB2-2]
DR ProteomicsDB; 72870; -. [Q8NCB2-3]
DR Antibodypedia; 2091; 209 antibodies from 29 providers.
DR DNASU; 79012; -.
DR Ensembl; ENST00000296471.11; ENSP00000296471.6; ENSG00000164076.17. [Q8NCB2-2]
DR Ensembl; ENST00000477224.6; ENSP00000419195.1; ENSG00000164076.17. [Q8NCB2-1]
DR Ensembl; ENST00000488336.5; ENSP00000418809.1; ENSG00000164076.17. [Q8NCB2-3]
DR Ensembl; ENST00000620470.4; ENSP00000484045.1; ENSG00000164076.17. [Q8NCB2-2]
DR GeneID; 79012; -.
DR KEGG; hsa:79012; -.
DR MANE-Select; ENST00000477224.6; ENSP00000419195.1; NM_024046.5; NP_076951.2.
DR UCSC; uc003cxt.2; human. [Q8NCB2-1]
DR CTD; 79012; -.
DR DisGeNET; 79012; -.
DR GeneCards; CAMKV; -.
DR HGNC; HGNC:28788; CAMKV.
DR HPA; ENSG00000164076; Tissue enriched (brain).
DR MIM; 614993; gene.
DR neXtProt; NX_Q8NCB2; -.
DR OpenTargets; ENSG00000164076; -.
DR PharmGKB; PA142672205; -.
DR VEuPathDB; HostDB:ENSG00000164076; -.
DR eggNOG; KOG0032; Eukaryota.
DR GeneTree; ENSGT00940000156468; -.
DR InParanoid; Q8NCB2; -.
DR OMA; CVTLGEK; -.
DR PhylomeDB; Q8NCB2; -.
DR TreeFam; TF314166; -.
DR PathwayCommons; Q8NCB2; -.
DR SignaLink; Q8NCB2; -.
DR BioGRID-ORCS; 79012; 18 hits in 1106 CRISPR screens.
DR ChiTaRS; CAMKV; human.
DR GenomeRNAi; 79012; -.
DR Pharos; Q8NCB2; Tbio.
DR PRO; PR:Q8NCB2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NCB2; protein.
DR Bgee; ENSG00000164076; Expressed in cortical plate and 98 other tissues.
DR ExpressionAtlas; Q8NCB2; baseline and differential.
DR Genevisible; Q8NCB2; HS.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IBA:GO_Central.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0099159; P:regulation of modification of postsynaptic structure; IEA:Ensembl.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calmodulin-binding; Cell membrane;
KW Cytoplasmic vesicle; Membrane; Phosphoprotein; Reference proteome.
FT CHAIN 1..501
FT /note="CaM kinase-like vesicle-associated protein"
FT /id="PRO_0000250094"
FT DOMAIN 24..286
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 327..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 435
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q63092"
FT MOD_RES 459
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHL1"
FT VAR_SEQ 188..215
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11230166, ECO:0000303|Ref.3"
FT /id="VSP_020600"
FT VAR_SEQ 352..382
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020601"
FT VARIANT 40
FT /note="R -> W (in a colorectal adenocarcinoma sample;
FT somatic mutation; dbSNP:rs1407808379)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041337"
FT VARIANT 60
FT /note="G -> S (in an ovarian serous carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041338"
FT VARIANT 274
FT /note="R -> W (in a colorectal adenocarcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041339"
FT VARIANT 279
FT /note="E -> D (in dbSNP:rs56071455)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041340"
FT VARIANT 472
FT /note="P -> L (in dbSNP:rs56307047)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041341"
FT VARIANT 491
FT /note="Y -> C (in dbSNP:rs17849325)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027539"
FT CONFLICT 22
FT /note="D -> G (in Ref. 3; CAG38539)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="R -> Q (in Ref. 1; BAC11528)"
FT /evidence="ECO:0000305"
FT CONFLICT 285
FT /note="W -> S (in Ref. 1; BAC11248)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 54354 MW; 1D6DBF8ABA0D1D70 CRC64;
MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH TCKKFQKRDG
RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE LATGREVFDW ILDQGYYSER
DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN LVYYNRLKNS KIVISDFHLA KLENGLIKEP
CGTPEYLAPE VVGRQRYGRP VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI
LAGDYEFDSP YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV
CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA AGGATAAAAS
GATSAPEGDA ARAAKSDNVA PADRSATPAT DGSATPATDG SVTPATDGSI TPATDGSVTP
ATDRSATPAT DGRATPATEE STVPTTQSSA MLATKAAATP EPAMAQPDST APEGATGQAP
PSSKGEEAAG YAQESQREEA S
