WAP1_PSEPL
ID WAP1_PSEPL Reviewed; 118 AA.
AC A7X4M1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Waprin-Enh1;
DE Flags: Precursor;
OS Pseudoferania polylepis (Macleay's water snake) (Enhydris polylepis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Homalopsidae; Pseudoferania.
OX NCBI_TaxID=338839;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=17855442; DOI=10.1074/mcp.m700094-mcp200;
RA Fry B.G., Scheib H., van der Weerd L., Young B., McNaughtan J.,
RA Ramjan S.F.R., Vidal N., Poelmann R.E., Norman J.A.;
RT "Evolution of an arsenal: structural and functional diversification of the
RT venom system in the advanced snakes (Caenophidia).";
RL Mol. Cell. Proteomics 7:215-246(2008).
CC -!- FUNCTION: Damages membranes of susceptible bacteria. Has no hemolytic
CC activity. Not toxic to mice. Does not inhibit the proteinases elastase
CC and cathepsin G. {ECO:0000250|UniProtKB:P83952}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}.
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DR EMBL; EU029745; ABU68545.1; -; mRNA.
DR AlphaFoldDB; A7X4M1; -.
DR SMR; A7X4M1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR Gene3D; 4.10.75.10; -; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 2.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Disulfide bond; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..118
FT /note="Waprin-Enh1"
FT /id="PRO_0000314685"
FT DOMAIN 25..72
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 74..118
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 30..63
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 40..67
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 50..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 56..71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 81..109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 88..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 96..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 102..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 118 AA; 13251 MW; 483C350AE7490932 CRC64;
MKTLTGLLLV GLLALWIGLP STSSKILFGC GISPGNPFPC SLPGLTGNRC RRDYDCPQTL
RCCNFRCSRS CRIPPVLPWS CPRNPFKCTI PGIDRCRYDY DCPGRQRCCY YSCSRICK