ID   WAP1_RHATT              Reviewed;          76 AA.
AC   A7X4J4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Waprin-Rha1;
DE   Flags: Precursor;
OS   Rhabdophis tigrinus tigrinus (Tiger keelback snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Natricinae; Rhabdophis.
OX   NCBI_TaxID=193080;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=17855442; DOI=10.1074/mcp.m700094-mcp200;
RA   Fry B.G., Scheib H., van der Weerd L., Young B., McNaughtan J.,
RA   Ramjan S.F.R., Vidal N., Poelmann R.E., Norman J.A.;
RT   "Evolution of an arsenal: structural and functional diversification of the
RT   venom system in the advanced snakes (Caenophidia).";
RL   Mol. Cell. Proteomics 7:215-246(2008).
CC   -!- FUNCTION: Damages membranes of susceptible bacteria. Has no hemolytic
CC       activity. Not toxic to mice. Does not inhibit the proteinases elastase
CC       and cathepsin G. {ECO:0000250|UniProtKB:P83952}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}.
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DR   EMBL; EU029741; ABU68541.1; -; mRNA.
DR   AlphaFoldDB; A7X4J4; -.
DR   SMR; A7X4J4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 1.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..76
FT                   /note="Waprin-Rha1"
FT                   /id="PRO_0000314690"
FT   DOMAIN          25..75
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        32..62
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        45..66
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        49..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        55..71
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   76 AA;  7912 MW;  D0A281E494562429 CRC64;
     MQARVFLLLL GVILLGMMGP MVSAQDGKAG SCPDVNQPIP PLGVCKTTCA TDSNCPDIQK
     CCKNGCGHMS CTRPST