WAP2_PHIOL
ID WAP2_PHIOL Reviewed; 73 AA.
AC A7X4K7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Waprin-Phi2;
DE Flags: Precursor;
OS Philodryas olfersii (Green snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Dipsadidae; Philodryas.
OX NCBI_TaxID=120305;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=17855442; DOI=10.1074/mcp.m700094-mcp200;
RA Fry B.G., Scheib H., van der Weerd L., Young B., McNaughtan J.,
RA Ramjan S.F.R., Vidal N., Poelmann R.E., Norman J.A.;
RT "Evolution of an arsenal: structural and functional diversification of the
RT venom system in the advanced snakes (Caenophidia).";
RL Mol. Cell. Proteomics 7:215-246(2008).
CC -!- FUNCTION: Damages membranes of susceptible bacteria. Has no hemolytic
CC activity. Not toxic to mice. Does not inhibit the proteinases elastase
CC and cathepsin G. {ECO:0000250|UniProtKB:P83952}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}.
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DR EMBL; EU029743; ABU68543.1; -; mRNA.
DR AlphaFoldDB; A7X4K7; -.
DR SMR; A7X4K7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR PROSITE; PS51390; WAP; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..73
FT /note="Waprin-Phi2"
FT /id="PRO_0000314688"
FT DOMAIN 22..72
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 29..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 42..63
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 46..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 52..68
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 73 AA; 7723 MW; AE0CCC618DC0E725 CRC64;
MKATLLLLLL FAVILPGTIS AEQEKPGSCP NVDMPIPPLG LCKTTCSKDS DCSETKKCCK
NGCGFMTCTT ARP