WAP3_PIG
ID WAP3_PIG Reviewed; 144 AA.
AC Q29126;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Protein WAP-3;
DE Flags: Precursor;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8636131; DOI=10.1074/jbc.271.12.7012;
RA Tamechika I., Itakura M., Saruta Y., Furukawa M., Kato A., Tachibana S.,
RA Hirose S.;
RT "Accelerated evolution in inhibitor domains of porcine elafin family
RT members.";
RL J. Biol. Chem. 271:7012-7018(1996).
CC -!- TISSUE SPECIFICITY: Large intestine (relatively low levels).
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DR EMBL; D50321; BAA08856.1; -; Genomic_DNA.
DR RefSeq; NP_001193482.1; NM_001206553.1.
DR AlphaFoldDB; Q29126; -.
DR SMR; Q29126; -.
DR MEROPS; I17.002; -.
DR PeptideAtlas; Q29126; -.
DR Ensembl; ENSSSCT00065103396; ENSSSCP00065045709; ENSSSCG00065074995.
DR GeneID; 100607966; -.
DR CTD; 100607966; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR019541; Trappin_transglut-bd_rpt.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF10511; Cementoin; 1.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR PROSITE; PS51390; WAP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Repeat; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..?
FT /evidence="ECO:0000250"
FT /id="PRO_0000041363"
FT CHAIN ?..144
FT /note="Protein WAP-3"
FT /id="PRO_0000041364"
FT REPEAT 34..39
FT /note="1"
FT REPEAT 40..45
FT /note="2"
FT REPEAT 46..51
FT /note="3"
FT REPEAT 58..63
FT /note="4"
FT REPEAT 64..69
FT /note="5"
FT REPEAT 70..75
FT /note="6"
FT REPEAT 76..81
FT /note="7"
FT REPEAT 82..87
FT /note="8"
FT DOMAIN 97..144
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT REGION 28..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34
FT /note="8 X 6 AA approximate tandem repeats"
FT REGION 64..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 104..132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 110..136
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 119..131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 125..140
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 144 AA; 15634 MW; 45B0AFA582894D29 CRC64;
MRSRSFLVLV AVFLICETLV AQRLDRIRGP KGQGQDPVEG QDQDEGQGPV KVEILDIGQD
LVKGQDPVEG QDPVKAQLPD KVQDPVKAQP PIQGGFLFPK PGVCPKIIFC PLVNPPIKCW
RDSHCPGVKK CCPSLCGKGC VTPR
