ID   WAPA_AUSSU              Reviewed;          75 AA.
AC   B5KGY9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Supwaprin-a;
DE   Flags: Precursor;
OS   Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Acanthophiinae; Austrelaps.
OX   NCBI_TaxID=29156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   St Pierre L.;
RT   "Identification and characterization of Waprins from the venom of
RT   Australian elapid snakes.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Damages membranes of susceptible bacteria. Has no hemolytic
CC       activity. Not toxic to mice. Does not inhibit the proteinases elastase
CC       and cathepsin G. {ECO:0000250|UniProtKB:P83952}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}.
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DR   EMBL; EF599320; ABW24188.1; -; mRNA.
DR   AlphaFoldDB; B5KGY9; -.
DR   SMR; B5KGY9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 1.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..75
FT                   /note="Supwaprin-a"
FT                   /id="PRO_5000395585"
FT   DOMAIN          27..72
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        34..60
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        43..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        47..59
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        53..68
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   75 AA;  8396 MW;  2DDADCC8BCF64300 CRC64;
     MSSGGLLLLL GFLTLWAELT PVSGQDRPKK PGLCPPRPQK PPCVRECKND WSCPGEQKCC
     RYGCIFECRD PIFVK