ID   WAPA_STRMU              Reviewed;         453 AA.
AC   P11000;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Wall-associated protein;
DE   Flags: Precursor;
GN   Name=wapA; OrderedLocusNames=SMU_987;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2761387; DOI=10.1111/j.1365-2958.1989.tb00193.x;
RA   Ferretti J.J., Russell R.R.B., Dao M.L.;
RT   "Sequence analysis of the wall-associated protein precursor of
RT   Streptococcus mutans antigen A.";
RL   Mol. Microbiol. 3:469-478(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
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DR   EMBL; M37842; AAA88608.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58688.1; -; Genomic_DNA.
DR   PIR; S06992; S06992.
DR   RefSeq; NP_721382.1; NC_004350.2.
DR   RefSeq; WP_002262850.1; NC_004350.2.
DR   AlphaFoldDB; P11000; -.
DR   SMR; P11000; -.
DR   STRING; 210007.SMU_987; -.
DR   PRIDE; P11000; -.
DR   EnsemblBacteria; AAN58688; AAN58688; SMU_987.
DR   KEGG; smu:SMU_987; -.
DR   PATRIC; fig|210007.7.peg.880; -.
DR   eggNOG; COG4932; Bacteria.
DR   HOGENOM; CLU_002287_5_0_9; -.
DR   OMA; HWKVLIN; -.
DR   PhylomeDB; P11000; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005518; F:collagen binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1280; -; 1.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   InterPro; IPR008456; Collagen-bd_dom.
DR   InterPro; IPR011252; Fibrogen-bd_dom1.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR041171; SDR_Ig.
DR   Pfam; PF17961; Big_8; 1.
DR   Pfam; PF05737; Collagen_bind; 1.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   SUPFAM; SSF49401; SSF49401; 2.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   3: Inferred from homology;
KW   Cell wall; Peptidoglycan-anchor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT   CHAIN           30..425
FT                   /note="Wall-associated protein"
FT                   /id="PRO_0000005673"
FT   PROPEP          426..453
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005674"
FT   REGION          331..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           422..426
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        337..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         425
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   CONFLICT        353..360
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   453 AA;  48900 MW;  FA13C4C39629A2D2 CRC64;
     MKMKRKLLSL VSVLTILLGA FWVTKIVKAD QVTNYTNTAS ITKSDGTALS NDPSKAVNYW
     EPLSFSNSIT FPDEVSIKAG DTLTIKLPEQ LQFTTALTFD VMHTNGQLAG KATTDPNTGE
     VTVTFTDIFE KLPNDKAMTL NFNAQLNHNN ISIPGVVNFN YNNVAYSSYV KDKDITPISP
     DVNKVGYQDK SNPGLIHWKV LINNKQGAID NLTLTDVVGE DQEIVKDSLV AARLQYIAGD
     DVDSLDEAAS RPYAEDFSKN VTYQTNDLGL TTGFTYTIPG SSNNAIFISY TTRLTSSQSA
     GKDVSNTIAI SGNNINYSNQ TGYARIESAY GRASSRVKRQ AETTTVTETT TSSSSETTTS
     EATTETSSTT NNNSTTTETA TSTTGASTTQ TKTTASQTNV PTTTNITTTS KQVTKQKAKF
     VLPSTGEQAG LLLTTVGLVI VAVAGVYFYR TRR