WAPA_TROCA
ID WAPA_TROCA Reviewed; 75 AA.
AC B5G6H2;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Carwaprin-a;
DE Flags: Precursor;
OS Tropidechis carinatus (Australian rough-scaled snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Notechinae; Tropidechis.
OX NCBI_TaxID=100989;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Venom gland;
RX PubMed=18979207; DOI=10.1007/s00018-008-8573-5;
RA St Pierre L., Earl S.T., Filippovich I., Sorokina N., Masci P.P.,
RA De Jersey J., Lavin M.F.;
RT "Common evolution of waprin and Kunitz-like toxin families in Australian
RT venomous snakes.";
RL Cell. Mol. Life Sci. 65:4039-4054(2008).
CC -!- FUNCTION: Damages membranes of susceptible bacteria. Has no hemolytic
CC activity. Not toxic to mice. Does not inhibit the proteinases elastase
CC and cathepsin G. {ECO:0000250|UniProtKB:P83952}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the snake waprin family. {ECO:0000305}.
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DR EMBL; DQ917561; ABK63590.1; -; mRNA.
DR EMBL; EU401827; ACC77776.1; -; Genomic_DNA.
DR AlphaFoldDB; B5G6H2; -.
DR SMR; B5G6H2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR PROSITE; PS51390; WAP; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..75
FT /note="Carwaprin-a"
FT /id="PRO_5000395572"
FT DOMAIN 27..72
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 34..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 43..64
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 47..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 53..68
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 75 AA; 8461 MW; 6C2C71265CE14866 CRC64;
MSSGGLLLLL GLLTLWAELT PISGQDRPKK PGLCPPRPQK PPCVRECKND WRCPGEQKCC
RYGCIYECRD PIFVK