ID   WAPP_COCIM              Reviewed;         309 AA.
AC   Q1DK59; J3K2R7; Q9C2W2;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Wall-associated proteinase;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   ORFNames=CIMG_09304;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-261, AND VARIANT GLY-196.
RC   STRAIN=RMSCC 2267 / CA1;
RX   PubMed=9144263; DOI=10.1073/pnas.94.10.5478;
RA   Koufopanou V., Burt A., Taylor J.W.;
RT   "Concordance of gene genealogies reveals reproductive isolation in the
RT   pathogenic fungus Coccidioides immitis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997).
RN   [4]
RP   ERRATUM OF PUBMED:9144263.
RA   Koufopanou V., Burt A., Taylor J.W.;
RL   Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-261, AND VARIANT GLY-196.
RC   STRAIN=IFM 45815, IFM 45816, IFM 46868, IFM 50992, and IFM 50995;
RX   PubMed=16699492; DOI=10.3314/jjmm.47.113;
RA   Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K.;
RT   "Reexamination of Coccidioides spp. reserved in the Research Center for
RT   Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a
RT   multiple gene analysis.";
RL   Nippon Ishinkin Gakkai Zasshi 47:113-117(2006).
CC   -!- FUNCTION: May participate in wall plasticization and/or intussusception
CC       or in cell wall turnover. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}. Membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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DR   EMBL; GG704915; EAS28100.3; -; Genomic_DNA.
DR   EMBL; AJ408861; CAC29127.1; -; Genomic_DNA.
DR   EMBL; AB232733; BAE20277.1; -; Genomic_DNA.
DR   EMBL; AB232734; BAE20278.1; -; Genomic_DNA.
DR   EMBL; AB232736; BAE20280.1; -; Genomic_DNA.
DR   EMBL; AB232737; BAE20281.1; -; Genomic_DNA.
DR   EMBL; AB232740; BAE20284.1; -; Genomic_DNA.
DR   RefSeq; XP_001239683.1; XM_001239682.2.
DR   AlphaFoldDB; Q1DK59; -.
DR   SMR; Q1DK59; -.
DR   EnsemblFungi; EAS28100; EAS28100; CIMG_09304.
DR   GeneID; 4558625; -.
DR   KEGG; cim:CIMG_09304; -.
DR   VEuPathDB; FungiDB:CIMG_09304; -.
DR   InParanoid; Q1DK59; -.
DR   OMA; IIYESTI; -.
DR   OrthoDB; 1802801at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell wall; Glycoprotein; Hydrolase; Membrane; Protease; Reference proteome;
KW   Secreted; Serine protease; Signal.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..309
FT                   /note="Wall-associated proteinase"
FT                   /id="PRO_0000252290"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        295
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         196
FT                   /note="A -> G (in strain: IFM 45815, IFM 45816, IFM 46868,
FT                   IFM 50992, IFM 50995 and RMSCC 2267 / CA1)"
FT                   /evidence="ECO:0000269|PubMed:16699492,
FT                   ECO:0000269|PubMed:9144263"
SQ   SEQUENCE   309 AA;  34228 MW;  7869872A66EB04C1 CRC64;
     MASPVTVLEN PIPKSGQHLL FFLTSKQQLA LEQRPIESSL GYSAYVDHGV SQGVIVNPSS
     IAAAMRSSLV TVYGITKPGT DKQYISVISP TYNLIANRQN QPIETTQKAL AACSDNDRNN
     WVYYLNLPQG TPQYAIYELN IQDSSSAPTV YSGPTPSGNS NLAAVYFSPN KDRFIIFSNT
     DTRHYLYWVN STLQSANRIS GTGSVMSASP LAATTITNVQ TRSMTIFLYY MDVNTLLNRI
     VGKVTDNEIH WYANQVVEGA PPMKVDTLLT GVVVEGKWNC LYYIPDGDTE FRAFNDTIRD
     SFFDEPREG