ID   WAPP_COCP7              Reviewed;         309 AA.
AC   P0CW96; C5PDD2; P42783; Q400X6; Q400Y3; Q400Y4; Q400Y5; Q9C2W3; Q9C2W4;
AC   Q9C2W5; Q9C2W6;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Wall-associated proteinase;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   ORFNames=CPC735_016940;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND PROTEIN SEQUENCE OF 65-95;
RP   206-231 AND 263-277.
RC   STRAIN=C634, and C735;
RX   PubMed=1730471; DOI=10.1128/iai.60.2.416-427.1992;
RA   Cole G.T., Zhu S., Hsu L., Kruse D., Seshan K.R., Wang F.;
RT   "Isolation and expression of a gene which encodes a wall-associated
RT   proteinase of Coccidioides immitis.";
RL   Infect. Immun. 60:416-427(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: May participate in wall plasticization and/or intussusception
CC       or in cell wall turnover.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall. Membrane; Peripheral
CC       membrane protein.
CC   -!- DEVELOPMENTAL STAGE: Expressed in active growth stages of the
CC       segmentation wall and during early endospore differentiation.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S77562; AAB20974.1; -; mRNA.
DR   EMBL; X63114; CAA44828.1; -; mRNA.
DR   EMBL; M81863; AAA33048.1; -; Genomic_DNA.
DR   EMBL; ACFW01000043; EER25093.1; -; Genomic_DNA.
DR   PIR; A43865; A43865.
DR   RefSeq; XP_003067238.1; XM_003067192.1.
DR   AlphaFoldDB; P0CW96; -.
DR   SMR; P0CW96; -.
DR   EnsemblFungi; EER25093; EER25093; CPC735_016940.
DR   GeneID; 9692709; -.
DR   KEGG; cpw:CPC735_016940; -.
DR   VEuPathDB; FungiDB:CPC735_016940; -.
DR   HOGENOM; CLU_900182_0_0_1; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell wall; Direct protein sequencing; Glycoprotein; Hydrolase; Membrane;
KW   Protease; Secreted; Serine protease; Signal.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..309
FT                   /note="Wall-associated proteinase"
FT                   /id="PRO_0000028519"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        295
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        168
FT                   /note="S -> P (in Ref. 1; AAA33048/AAB20974/CAA44828)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   309 AA;  34287 MW;  DE7CBBC35C2A4F80 CRC64;
     MASPVTVLEN PIPKSGQHLL FFLTSKQQLA LEQRPIESSL GYSAYVDHGV SQGVIVNPSS
     IAAAMRSSLI TVYGITKPGT DKQYISVISP TYNLIANRQN QPIETTQKAL AACSDNDRNN
     WVYYLNLPQG TAQYAIYELN IQDSTSAPTV YSGPTPSGNS NLAAVYFSPN KDRFIIFSNT
     DTRHYLYWVN STLQSANRIA GTGSVMSASP LAATTITNVQ TRSMTIFLYY MDVNTLLNRI
     VGKVTDNEIH WYANQVVEGA PPMKVDTLLT GVVVEEKWNC LYYIPDGDTE FRAFNDTIRD
     SFFDEPREG