ID   WAP_CAMDR               Reviewed;         117 AA.
AC   P09837;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Whey acidic protein;
DE            Short=WAP;
GN   Name=WAP;
OS   Camelus dromedarius (Dromedary) (Arabian camel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX   NCBI_TaxID=9838;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Milk;
RX   PubMed=3743571; DOI=10.1111/j.1432-1033.1986.tb09852.x;
RA   Beg O.U., von Bahr-Lindstroem H., Zaidi Z.H., Joernvall H.;
RT   "A camel milk whey protein rich in half-cystine. Primary structure,
RT   assessment of variations, internal repeat patterns, and relationships with
RT   neurophysin and other active polypeptides.";
RL   Eur. J. Biochem. 159:195-201(1986).
CC   -!- FUNCTION: Could be a protease inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk
CC       whey.
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DR   PIR; A24178; A24178.
DR   AlphaFoldDB; P09837; -.
DR   SMR; P09837; -.
DR   STRING; 9838.ENSCDRP00005003493; -.
DR   MEROPS; I17.001; -.
DR   Ensembl; ENSCDRT00005003839; ENSCDRP00005003493; ENSCDRG00005002448.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.75.10; -; 2.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 2.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 2.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein;
KW   Protease inhibitor; Repeat; Secreted.
FT   CHAIN           1..117
FT                   /note="Whey acidic protein"
FT                   /id="PRO_0000188984"
FT   DOMAIN          4..54
FT                   /note="WAP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DOMAIN          61..111
FT                   /note="WAP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        13..41
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        24..46
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        28..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        34..50
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        68..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        80..103
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        86..98
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        92..107
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   117 AA;  12564 MW;  2D9BB6A5A37A921B CRC64;
     LAPALSLPGQ AVCPELSSSE DNACIISCVN DESCPQGTKC CARSPCSRSC TVPLMVSSPE
     PVLKDGRCPW VQTPLTAKHC LEKNDCSRDD QCEGNKKCCF SSCAMRCLDP VTEDSFQ