ID   WAP_RABIT               Reviewed;         127 AA.
AC   P09412;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Whey acidic protein;
DE            Short=WAP;
DE   Flags: Precursor;
GN   Name=WAP;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=3419910; DOI=10.1093/nar/16.16.8180;
RA   Devinoy E., Hubert C., Schaerer E., Houdebine L.-M., Kraehenbuhl J.-P.;
RT   "Sequence of the rabbit whey acidic protein cDNA.";
RL   Nucleic Acids Res. 16:8180-8180(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2362817; DOI=10.1093/nar/18.12.3641;
RA   Thepot D., Devinoy E., Fontaine M.-L., Hubert C., Houdebine L.M.;
RT   "Complete sequence of the rabbit whey acidic protein gene.";
RL   Nucleic Acids Res. 18:3641-3641(1990).
CC   -!- FUNCTION: Could be a protease inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk
CC       whey.
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DR   EMBL; X52564; CAA36798.1; -; Genomic_DNA.
DR   EMBL; X07943; CAA30764.1; -; mRNA.
DR   PIR; S01286; S01286.
DR   RefSeq; NP_001075859.1; NM_001082390.2.
DR   AlphaFoldDB; P09412; -.
DR   STRING; 9986.ENSOCUP00000019065; -.
DR   Ensembl; ENSOCUT00000022305; ENSOCUP00000019065; ENSOCUG00000022314.
DR   GeneID; 100009255; -.
DR   KEGG; ocu:100009255; -.
DR   CTD; 22373; -.
DR   eggNOG; ENOG502RXHY; Eukaryota.
DR   GeneTree; ENSGT00730000111762; -.
DR   HOGENOM; CLU_156961_0_0_1; -.
DR   InParanoid; P09412; -.
DR   OMA; PQGTKCC; -.
DR   OrthoDB; 1409658at2759; -.
DR   TreeFam; TF339378; -.
DR   Proteomes; UP000001811; Chromosome 10.
DR   Bgee; ENSOCUG00000022314; Expressed in prefrontal cortex.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.75.10; -; 2.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 2.
DR   SMART; SM00217; WAP; 2.
DR   SUPFAM; SSF57256; SSF57256; 2.
DR   PROSITE; PS51390; WAP; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Milk protein; Protease inhibitor; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..127
FT                   /note="Whey acidic protein"
FT                   /id="PRO_0000041352"
FT   DOMAIN          26..68
FT                   /note="WAP 1; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DOMAIN          71..121
FT                   /note="WAP 2; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        32..56
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        49..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        78..109
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        90..113
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        96..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   127 AA;  13526 MW;  59DAD5FBFD2E2087 CRC64;
     MRCLISLALG LLALEAALAL APKFIAPVQV MCPEPSSSEE TLCLSDNDCL GSTVCCPSAA
     GGSCRTPIIV PTPKAGRCPW VQAPMLSQLC EELSDCANDI ECRGDKKCCF SRCAMRYLEP
     ILESTPQ