WARA_DICDI
ID WARA_DICDI Reviewed; 803 AA.
AC Q54F46; O43988;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Homeobox protein Wariai;
DE AltName: Full=Homeobox protein 1;
DE Short=DdHbx-1;
GN Name=warA; Synonyms=hbx1, wri; ORFNames=DDB_G0291075;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=AX3;
RX PubMed=9486804; DOI=10.1242/dev.125.2.313;
RA Han Z., Firtel R.A.;
RT "The homeobox-containing gene Wariai regulates anterior-posterior
RT patterning and cell-type homeostasis in Dictyostelium.";
RL Development 125:313-325(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Putative transcription factor, that seems to be involved in
CC anterior-posterior patterning of the slug, probably by controlling the
CC proportions of prestalk and prespore cells.
CC {ECO:0000269|PubMed:9486804}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Specifically expressed in pstA cells. Expression
CC is not detected in pstO or prespore cells.
CC {ECO:0000269|PubMed:9486804}.
CC -!- DISRUPTION PHENOTYPE: Cells show an approximately 2.5-fold increase in
CC the number of pstO cells and the size of the pstO domain and a
CC concomitant decrease in prespore cells and the size of the prespore
CC domain. {ECO:0000269|PubMed:9486804}.
CC -!- MISCELLANEOUS: 'Wariai' means 'proportioning' or 'ratio' in Japanese.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF036170; AAB92245.1; -; mRNA.
DR EMBL; AAFI02000175; EAL61885.1; -; Genomic_DNA.
DR RefSeq; XP_635408.1; XM_630316.1.
DR AlphaFoldDB; Q54F46; -.
DR SMR; Q54F46; -.
DR STRING; 44689.DDB0191441; -.
DR PaxDb; Q54F46; -.
DR EnsemblProtists; EAL61885; EAL61885; DDB_G0291075.
DR GeneID; 8627992; -.
DR KEGG; ddi:DDB_G0291075; -.
DR dictyBase; DDB_G0291075; warA.
DR eggNOG; KOG0490; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_350738_0_0_1; -.
DR InParanoid; Q54F46; -.
DR OMA; HASIMGH; -.
DR PRO; PR:Q54F46; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IMP:dictyBase.
DR GO; GO:0031286; P:negative regulation of sorocarp stalk cell differentiation; IMP:dictyBase.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..803
FT /note="Homeobox protein Wariai"
FT /id="PRO_0000328098"
FT REPEAT 374..403
FT /note="ANK 1"
FT REPEAT 407..436
FT /note="ANK 2"
FT REPEAT 440..469
FT /note="ANK 3"
FT REPEAT 474..503
FT /note="ANK 4"
FT REPEAT 507..536
FT /note="ANK 5"
FT REPEAT 540..569
FT /note="ANK 6"
FT REPEAT 573..602
FT /note="ANK 7"
FT REPEAT 606..636
FT /note="ANK 8"
FT REPEAT 642..671
FT /note="ANK 9"
FT DNA_BIND 162..221
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 23..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..321
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 305..307
FT /note="Missing (in Ref. 1; AAB92245)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="N -> D (in Ref. 1; AAB92245)"
FT /evidence="ECO:0000305"
FT CONFLICT 465
FT /note="A -> R (in Ref. 1; AAB92245)"
FT /evidence="ECO:0000305"
FT CONFLICT 553..554
FT /note="HD -> QY (in Ref. 1; AAB92245)"
FT /evidence="ECO:0000305"
FT CONFLICT 667
FT /note="A -> R (in Ref. 1; AAB92245)"
FT /evidence="ECO:0000305"
FT CONFLICT 672
FT /note="A -> R (in Ref. 1; AAB92245)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 803 AA; 88800 MW; ED80E22C67D19BC8 CRC64;
MASIVMKSQH SLGYPNIGNI NRSDYDSYEQ QYNNPTGSKQ YNNNNNNNTN TNEINNGTNT
NLNPNNMYGM YNNNNNNNNN NNNNNNNNNN NNNSNNNNNN NNNNNINNNN NNNNNNNNNN
NNNNQHLSQS QQLSPTPYSS NSFSKLLSRS TNDLMLDQDD PSKKKRKRTS PDQLKLLEKI
FMAHQHPNLN LRSQLAVELH MTARSVQIWF QNRRAKARNM EFKPQLSHGG SDLIYNALGS
QNGMNSMGGG GGNGGGNGGG GMNGINNILN GNHNRNLNKY IPHGGNSING NMGGGGGGGG
GSHNHHHHNH NHNHHNHNHN HNHNQPLSNG DCGEKFSVAS AWNKILLHPN NIDFLIRYNP
DDPNSIDVNA RDSKGLSLLF TAAFLGYEYQ VRRLIESGAN PNIKDNQGNT PLIAASVLGN
QPIVELLLEH RADPNLVNDE GVSPLFSACK GGHLQIASSL LDHDAEVSVK TKINGETPLH
IASLKGFEKI CKLLIETEAK ASVIDSNNRT PLHHACIMGY FSIAKLLICN GADMNAIDID
GHTPLHTSSL MGHDLITRLL LENGADPNIQ DSEGYTPIHY AVRESRIETV KFLIKFNSKL
NIKTKNGQNL IHLSVQFASL MMGQMIFESK GCEIAADDSD DQGYTPLYLA AKAGKTNFVK
YLLSKGASKK IALEKLIQEN QDKEIIQMLE STVTKSSNNN NSNSNINNIN NINNINNINS
QPNTNSDNNN NNNNNNFNEN YSNGNNEQSQ PPGNKFEEDD EDDFYDRVYK KSYTNRIISN
SFSYQQKLNS GNGISVNSGN LED
