WASC2_DROME
ID WASC2_DROME Reviewed; 1469 AA.
AC A1ZBW7; Q1EC81; Q960K6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=WASH complex subunit 2 {ECO:0000250|UniProtKB:Q6PGL7};
GN ORFNames=CG16742;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 982-1469.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-227; SER-422;
RP SER-426; SER-580; THR-587; THR-693; SER-1241; SER-1245; SER-1254; SER-1380;
RP SER-1381 AND SER-1408, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1344, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [7]
RP SUBUNIT.
RX PubMed=20498093; DOI=10.1073/pnas.0913293107;
RA Jia D., Gomez T.S., Metlagel Z., Umetani J., Otwinowski Z., Rosen M.K.,
RA Billadeau D.D.;
RT "WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein
RT (WASP) family are controlled by analogous structurally related complexes.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:10442-10447(2010).
CC -!- FUNCTION: Acts at least in part as component of the WASH complex which
CC may regulate wash nucleation-promoting factor (NPF) activity and is
CC required for its membrane targeting during endosomal sorting.
CC {ECO:0000250|UniProtKB:Q9Y4E1}.
CC -!- SUBUNIT: Component of the WASH complex. {ECO:0000269|PubMed:20498093}.
CC -!- SIMILARITY: Belongs to the FAM21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93436.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF57444.1; -; Genomic_DNA.
DR EMBL; BT025853; ABF85753.1; -; mRNA.
DR EMBL; AY052012; AAK93436.1; ALT_INIT; mRNA.
DR RefSeq; NP_611496.1; NM_137652.4.
DR AlphaFoldDB; A1ZBW7; -.
DR BioGRID; 62981; 3.
DR IntAct; A1ZBW7; 2.
DR STRING; 7227.FBpp0085541; -.
DR iPTMnet; A1ZBW7; -.
DR PaxDb; A1ZBW7; -.
DR PRIDE; A1ZBW7; -.
DR EnsemblMetazoa; FBtr0086227; FBpp0085541; FBgn0034529.
DR GeneID; 37331; -.
DR KEGG; dme:Dmel_CG16742; -.
DR UCSC; CG16742-RA; d. melanogaster.
DR UCSC; CG16742-RB; d. melanogaster.
DR CTD; 37331; -.
DR FlyBase; FBgn0034529; CG16742.
DR VEuPathDB; VectorBase:FBgn0034529; -.
DR eggNOG; ENOG502QTIY; Eukaryota.
DR GeneTree; ENSGT00940000153997; -.
DR HOGENOM; CLU_259063_0_0_1; -.
DR InParanoid; A1ZBW7; -.
DR OMA; IHTIFYD; -.
DR OrthoDB; 795671at2759; -.
DR PhylomeDB; A1ZBW7; -.
DR BioGRID-ORCS; 37331; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37331; -.
DR PRO; PR:A1ZBW7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034529; Expressed in oviduct (Drosophila) and 24 other tissues.
DR Genevisible; A1ZBW7; DM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:FlyBase.
DR GO; GO:0071203; C:WASH complex; IDA:UniProtKB.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR GO; GO:1905394; F:retromer complex binding; IBA:GO_Central.
DR GO; GO:0140591; P:nuclear envelope budding; IMP:FlyBase.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IMP:FlyBase.
DR GO; GO:0036010; P:protein localization to endosome; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1469
FT /note="WASH complex subunit 2"
FT /id="PRO_0000372653"
FT REGION 178..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 351..372
FT /note="LFa 1"
FT /evidence="ECO:0000250|UniProtKB:Q9Y4E1"
FT MOTIF 550..563
FT /note="LFa 5"
FT /evidence="ECO:0000250|UniProtKB:Q9Y4E1"
FT MOTIF 595..605
FT /note="LFa 6"
FT /evidence="ECO:0000250|UniProtKB:Q9Y4E1"
FT MOTIF 698..709
FT /note="LFa 8"
FT /evidence="ECO:0000250|UniProtKB:Q9Y4E1"
FT COMPBIAS 178..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1135
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 227
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 422
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 426
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 580
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 587
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 693
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1241
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1245
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1254
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1344
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 1380
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1381
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1408
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 66
FT /note="T -> N (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="N -> K (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="V -> A (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="N -> S (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 397..399
FT /note="EYP -> PYS (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 405
FT /note="K -> T (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="T -> I (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="R -> Q (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="N -> D (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 502
FT /note="K -> R (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 506
FT /note="P -> T (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 619
FT /note="D -> Y (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 623..624
FT /note="EA -> DT (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 925
FT /note="N -> S (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 981..982
FT /note="KE -> NQ (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1021
FT /note="P -> T (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1035
FT /note="S -> N (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1065
FT /note="L -> H (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1071
FT /note="S -> G (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1086
FT /note="R -> K (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1095
FT /note="T -> P (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1150
FT /note="N -> D (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1155
FT /note="A -> S (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1208
FT /note="F -> L (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1222..1224
FT /note="VPT -> IPK (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1233
FT /note="T -> S (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1259
FT /note="N -> S (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1262..1266
FT /note="GINVV -> CFNEP (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1271
FT /note="K -> NLQ (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1281
FT /note="A -> D (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1296
FT /note="N -> K (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1310
FT /note="M -> V (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1319
FT /note="A -> S (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1392
FT /note="S -> T (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
FT CONFLICT 1402
FT /note="P -> T (in Ref. 3; ABF85753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1469 AA; 160899 MW; 945E8CD6C834677D CRC64;
MDISADVDQI IAQAPDWTFA GDCALLALMK RISQNLEERG ERTSRNLRDF ETSVKQVDIA
LNNATTSLRS LQFGNQFVEY RVEEVDDADL AMPEEKKKKP ELPLKSSEEL AKEFLENNLR
MFRKNYEPVT IEVPDSDDED GPVHSTTVFR AKNPYDAIPL PYIIGTKEWQ EHKYAGLYDS
KENSEDDRSE EFSSSSSDEK EPETKKIATP ANKLEEQHLS DSSSLASFAR EPAIVSPVIN
PAVQVAEPVI RTQPRPIINS QRNPHERDMF AALRQSPPSD DPPSTSSSPT SSPAFRNPSS
RLPIVSTASL SSSSSSPAQQ PPRLFDEAVS TQTPKEAEIK PSQTKRMPVN LFNEDEFKSF
MSEIVDKVQS KTPSSSVSPA TTISTKEPPK TKKPVEEYPK PGPPKQIVEQ TVPKRVNLFD
DSPPLSPTPR SEPVFNNTKA TGAIPKRSPV VVANNDEDNS LFGSSPAMPK ENPSKKPPKP
VTKSLFDDDL EDDDFLSSFT PKAKPPEQKL LSKPKPSLFD DDDLDIDDIF TKPSAQPKKL
SERVAGKTSL FEDDDQDDVT DLFGSKKAKV IPKETSSGVS PNKNVETPVA SKKSLFDDIE
DEDLFGTPKA KNLIRSEPDN DPEAVGEDKK QSEIAEQKSK NIETGEKQHQ VIAENASVPI
LRDSPPPMEV TEQKSDDKEW EAVKDDTSAA NITKSKDLFS EDLTDDELFS STSNNMAEPK
SANETNEFNK PIEKYTSQTE ENVSPVNPPT KLSIKPTDLF NEDFSDDDTF LSASMSKNEP
LVGTENEDIK KPSEVQLVKE IKAEELPQQL PENKIYEITA VVEKDELVPE MLSKPQIDEP
VSETPPPDDY QSNVDPIISM VADVTNKTSV DTLTPRKPAD LAAAQQIMQN YSNLFSDEPP
DDSEFFQTLG SSGLSSLSAS KIFDNEHDFF EPALPNIPSA TKPSPVTPGD QPSVSSDYGA
MCLFSDVPPE DNDHAGEEVQ KEAEPQKDEL ASTTRIHTIF YDDFSETARA GAVQPAPKRF
PFDDEPPPAD ETDRSEVKET PELQKPTSPV KKLKMPNINI NVHALLPGSG SVPKLIRKQE
SSSSERDEPQ ATVQTEAEAP SSGQNTVSSA DGVLQHVNKS RARGPAKRRP STRRGRKENY
AKSLLDAGQN EGPTASTRDS PEVEHSERSS IKAPSPQYVK PEKLFSTPAQ QIQPQLQRPP
PSNTGGSFLD SPDEDDSFFN SVPTKTVEGK QGTDPPKSYR SFLDSPDADD KLFSDLENNK
AGINVVPVEK KPPKMANSFL ASPDEDDFLF DSVKTNATTT AQKAFAAEIM NAFQKVTTAP
PKPSNAKEAA KPKSQAAPKL FDDSDDDDDD LFARAPSIQT ASKPVQAKQP PKPAATSLFS
SDDEEAEVPV KSAPAKKLPV KPSKSLFSDD DDDDDLFGGS STSKAAAAKK TKPAARTASK
PPASKTTTPT ATIPSNSGDN PLADLLDFK
