WASC3_DANRE
ID WASC3_DANRE Reviewed; 200 AA.
AC Q5RGJ6; Q7ZVR9;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=WASH complex subunit 3 {ECO:0000250|UniProtKB:Q9Y3C0};
DE AltName: Full=Coiled-coil domain-containing protein 53;
GN Name=washc3 {ECO:0000250|UniProtKB:Q9Y3C0}; Synonyms=ccdc53;
GN ORFNames=Ch211-234f20.5, zgc:55718;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the WASH complex. {ECO:0000250|UniProtKB:Q9Y3C0}.
CC -!- SIMILARITY: Belongs to the CCDC53 family. {ECO:0000305}.
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DR EMBL; BX890572; CAI11846.1; -; Genomic_DNA.
DR EMBL; BC045438; AAH45438.1; -; mRNA.
DR RefSeq; NP_956467.1; NM_200173.1.
DR AlphaFoldDB; Q5RGJ6; -.
DR SMR; Q5RGJ6; -.
DR STRING; 7955.ENSDARP00000066998; -.
DR PaxDb; Q5RGJ6; -.
DR Ensembl; ENSDART00000066999; ENSDARP00000066998; ENSDARG00000045563.
DR GeneID; 393142; -.
DR KEGG; dre:393142; -.
DR CTD; 51019; -.
DR ZFIN; ZDB-GENE-040426-783; washc3.
DR eggNOG; KOG4496; Eukaryota.
DR GeneTree; ENSGT00390000014084; -.
DR HOGENOM; CLU_117940_0_0_1; -.
DR InParanoid; Q5RGJ6; -.
DR OMA; GCETKFV; -.
DR OrthoDB; 1425330at2759; -.
DR PhylomeDB; Q5RGJ6; -.
DR TreeFam; TF318955; -.
DR PRO; PR:Q5RGJ6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000045563; Expressed in intestine and 28 other tissues.
DR GO; GO:0071203; C:WASH complex; ISS:UniProtKB.
DR GO; GO:0030041; P:actin filament polymerization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR InterPro; IPR019309; WASHC3.
DR PANTHER; PTHR13015; PTHR13015; 1.
DR Pfam; PF10152; CCDC53; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..200
FT /note="WASH complex subunit 3"
FT /id="PRO_0000390955"
FT REGION 87..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 56..76
FT /evidence="ECO:0000255"
FT COMPBIAS 97..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 85
FT /note="D -> E (in Ref. 2; AAH45438)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 21565 MW; 86CDC5A086034B48 CRC64;
MDADGLPIVG SGVDLTKVPA IQQRRIVAFL NQFIVHTVRF LNRFSTVCEE KLSTVSLRIQ
QIETTLSILE AKLASIPGLE EVTVDGVRAP AETNGPAADT SRATAPPAEA SQQTQAAPQE
PKTEAPAENI MTVAKDPRYA RYLKMVQVGV PVMAIKNKMM MEGLDPNLLD TPDAAVPDAS
KKRLEEQDDD SSGSESSFSD
