ID   WASC5_DICDI             Reviewed;        1164 AA.
AC   Q54IR8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=WASH complex subunit 5 {ECO:0000250|UniProtKB:Q12768};
DE   AltName: Full=WASH complex subunit strumpellin homolog {ECO:0000305};
GN   Name=washc5 {ECO:0000250|UniProtKB:Q12768}; ORFNames=DDB_G0288569;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-71; 164-187; 191-245; 310-337; 414-423; 432-453;
RP   457-484; 510-516; 572-587; 613-663; 692-826; 881-898; 938-984; 1096-1116
RP   AND 1135-1164, CLEAVAGE OF INITIATOR METHIONINE, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   STRAIN=AX2;
RA   Bienvenut W.V., Ura S., Insall R.H.;
RL   Submitted (JUL-2009) to UniProtKB.
CC   -!- SUBUNIT: Probable component of the WASH complex.
CC       {ECO:0000250|UniProtKB:Q12768}.
CC   -!- SIMILARITY: Belongs to the strumpellin family. {ECO:0000305}.
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DR   EMBL; AAFI02000117; EAL63144.1; -; Genomic_DNA.
DR   RefSeq; XP_636646.1; XM_631554.1.
DR   AlphaFoldDB; Q54IR8; -.
DR   STRING; 44689.DDB0234050; -.
DR   PaxDb; Q54IR8; -.
DR   PRIDE; Q54IR8; -.
DR   EnsemblProtists; EAL63144; EAL63144; DDB_G0288569.
DR   GeneID; 8626692; -.
DR   KEGG; ddi:DDB_G0288569; -.
DR   dictyBase; DDB_G0288569; washc5.
DR   eggNOG; KOG3666; Eukaryota.
DR   HOGENOM; CLU_004021_1_0_1; -.
DR   InParanoid; Q54IR8; -.
DR   OMA; FQSIHHY; -.
DR   PhylomeDB; Q54IR8; -.
DR   PRO; PR:Q54IR8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0071203; C:WASH complex; IDA:dictyBase.
DR   GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR   GO; GO:0030041; P:actin filament polymerization; IMP:dictyBase.
DR   GO; GO:0140285; P:endosome fission; IMP:MGI.
DR   GO; GO:0007032; P:endosome organization; IMP:dictyBase.
DR   GO; GO:0006887; P:exocytosis; IMP:dictyBase.
DR   GO; GO:0007040; P:lysosome organization; IMP:dictyBase.
DR   GO; GO:0006909; P:phagocytosis; IMP:MGI.
DR   GO; GO:0044655; P:phagosome reneutralization; IMP:dictyBase.
DR   GO; GO:0043933; P:protein-containing complex organization; IMP:MGI.
DR   GO; GO:0051125; P:regulation of actin nucleation; IBA:GO_Central.
DR   InterPro; IPR019393; WASH_strumpellin.
DR   PANTHER; PTHR15691; PTHR15691; 1.
DR   Pfam; PF10266; Strumpellin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|Ref.2"
FT   CHAIN           2..1164
FT                   /note="WASH complex subunit 5"
FT                   /id="PRO_0000329311"
SQ   SEQUENCE   1164 AA;  134897 MW;  17865EB8513B9A6A CRC64;
     MVKEFLGEGS QAGQNLLRLV SRGNAIIAEL LRLSAHIPSV FKLEDRNEAR KYQDILLDFK
     YLSNPDFYES KIEENADLVD LETEFRDNHI DILIRFYHLF ESIYKYIMDL EHYIVDVEKG
     FYIHLTIEAI LINGDGKQLL SEAVYLYGVM LILMDNLIEG PVRERMLISY LRNKGPVDLP
     LIDEVCKLCK STGYIPGSPK KPPNYPEEYF RRVELPENVI SMIVGRLRSD DLYNGTESFP
     QPEHRSVALS TQACMIYVIL YFIPDILNNK NSIMREIVDK FFPDNWVISF FLGFTIDLSV
     AWEPYKAAKT AMGNTIIQSN IQYQTQRFWK EVSELNKLVD DLLVDGLLVE EYIVDNVHKI
     ITTLRRCNVT IRWVMLHSNA SQKKFKDLVL MGGSQEDVLY LLLNTAQLEF VFKNIFQQLL
     ATKEEKWEEN KKLASDSMVE LSEYFSGEKA LTRVKKNENL QKWFGEISQK ISQLDSTDST
     STGRKIQQLS LALEEVEQFQ QIDSSIQVKQ FLIETRQFLT KMIKIVNIKE EVLVNLSVCA
     DMSYAWEIVN NYVDQMQKGI KSDPKCVLKL RATFLKLVSI LDLPLVRIAQ CSSPDLISVS
     EYYSGELVGY VRKVLEIVPK QMFLILKQII NMQTNNIQEM PTKVEKERLR DFAQLDQRYD
     LARATHSVSV FTEGILAMET TLVGIIEVDP KQLLEDGIRK ELVLQIALAM DKTLIFSGKP
     YQAPSNKQQQ QEIELLQRLK ELSNILDGFR RSFQYIQDYV NIQGLKIWQE EFSRIVNFYV
     EQECNSFLKK KVYDWQSQYQ SVAIPIPKFP SQSDQNSQQS VNMIGRLARE LLNQTNCKTT
     LYLNQIGWFD PSSGKELVGI NTWSILHQSV GIFGLTGLDK LFSFMMVKDL QVFVSQTRSL
     VEKSLKGFLN EFEDYLRPTT NIPDTMIRYQ QALDKTKLLY PIFIDVLTKI GQIQLIRRQI
     SNQLNFHCKI DSNMLFSSLD IMNKSLLNDI ESHFQRPDSN PYPSDDNTLL FDLAQYLDTA
     GINDPFTKIY ITTSPLEQFP CLLFLFVLSQ VSKFQFNSKL NVMSSKKQKN SYDWTPFIIG
     CITILQQFHS LHTQKFLAFV GQYIKSHINI ALANPKENNK DDADYPEDVI GLLRFLEDFC
     KYSHTSRKIV EGYVPPYIFD YYNN