ID   WASC5_XENTR             Reviewed;        1159 AA.
AC   Q6DIP9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=WASH complex subunit 5 {ECO:0000250|UniProtKB:Q12768};
DE   AltName: Full=WASH complex subunit strumpellin {ECO:0000305};
GN   Name=washc5 {ECO:0000250|UniProtKB:Q12768};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts at least in part as component of the WASH complex which
CC       seems to regulate washc1 nucleation-promoting factor (NPF) activity and
CC       is required for its membrane targeting during endosomal sorting.
CC       {ECO:0000250|UniProtKB:Q12768}.
CC   -!- SUBUNIT: Component of the WASH complex. {ECO:0000250|UniProtKB:Q12768}.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the strumpellin family. {ECO:0000305}.
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DR   EMBL; BC075486; AAH75486.1; -; mRNA.
DR   RefSeq; NP_001004970.1; NM_001004970.1.
DR   AlphaFoldDB; Q6DIP9; -.
DR   STRING; 8364.ENSXETP00000054061; -.
DR   PaxDb; Q6DIP9; -.
DR   GeneID; 448397; -.
DR   KEGG; xtr:448397; -.
DR   CTD; 9897; -.
DR   Xenbase; XB-GENE-5781989; washc5.
DR   eggNOG; KOG3666; Eukaryota.
DR   InParanoid; Q6DIP9; -.
DR   OrthoDB; 88928at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0071203; C:WASH complex; ISS:UniProtKB.
DR   GO; GO:0030041; P:actin filament polymerization; IBA:GO_Central.
DR   GO; GO:0140285; P:endosome fission; IBA:GO_Central.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0051125; P:regulation of actin nucleation; IBA:GO_Central.
DR   InterPro; IPR019393; WASH_strumpellin.
DR   PANTHER; PTHR15691; PTHR15691; 1.
DR   Pfam; PF10266; Strumpellin; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1159
FT                   /note="WASH complex subunit 5"
FT                   /id="PRO_0000318932"
SQ   SEQUENCE   1159 AA;  134000 MW;  55DC299F5070AE0F CRC64;
     MVDFLAENNL CGQAILRIVS RGNAIIAELL RLSEFVPSVF RLKDKADQQK YGDIIFDFSY
     FKGPEVCEGR LEAKPELQDL DEEFRENNIE ILTRFYLAFE SVHKYIVDLN RYLEDLNEGI
     YIQQTLETVL LNEDGKQLLC EALYLYGVML LVIDQKIEGE VRERMLVAYY RYSAARSSVD
     SNMDDICKLL RSTGYSSQPG AKRPPNYPES YFSRVPISET FISMVIGRLR SDDIYNQVSA
     YPLPEHRSTA LATQAAILYV ILYFHPPTLH THQAKMREIV DKYFPDNWVI SIYMGITVNL
     MEVWEPYKAA KTALNYTLDL PNIKEQASRY AKIIESLHPQ VQQFLKEGFL REEFVLDNIP
     KLLNCLRDCN VAIRWLMLHT ADSAYDPNNK RLRQVKDQVL ADSKYNPKIL FQLLLDTAQF
     EFLLKEMFKQ MLSEKQNKWE SYKKEGSERM TELADVFSGV KPLTRVEKNE HLQAWFREIA
     KQIHSLNYDD STAAGRKTVQ LIQALEEVQE FHQLETNLQV CQFLADTRKF LHQMIRTINI
     KEEVLITMQI VGDLSYAWQL IDSFTAIMQE SIRANPSMVT KLRATFLKLA SALDLPLLRI
     NQANSPDLLS VSQYYSGELV FYVRKVLQII PESMFTSLAK IIKLQTHDII EVPTRLDKDK
     LRDYAQLGAR YEVAKLTNAI SIFTEGILMM KTTLVGIIKV DPKQLLEDGI RKELVKRVAV
     ALHKGLIFNS RAKPSELLPK LKDMAATMDG FHRSFEYIQD YVSIYGLKIW QEEVSRIVNY
     NVEQECNNFL RTKIQDWQSM YQSTHIPIPK FPPVDESMTF IGRLCREILR ITDPKVTCYI
     DQMNTWYDMK THQEVTNNHL FSEINDSLGT FGLNGLDRLL CFMIVKELQN FIRLYQRLIL
     RDKSGQETLR ALQKVVTPVK GIVANSAKIY SAAIAKTQKI WPAYLDAIMK VGQMQVLRQQ
     IANELNYSCK FDSKHLAGAL ENFNEAILAD IQAHYQDPSL PCPREDNTLL YEITAYLEAA
     GTHNPLNKIY ITTKQLSFFP IVNFLFLVAQ LPKLQYNKNL GMTCRKPADP IDWVPLVLGL
     LTLLKQFHSR YTEQFLALIG QFIRSSLEQS TSQKIPEMPA DVVGALMFLE DYVHFAKLPR
     RVVEAHVPNF IFDEFRTIQ