WAV2_ARATH
ID WAV2_ARATH Reviewed; 308 AA.
AC Q8RXP6;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Alpha/beta hydrolase domain-containing protein WAV2 {ECO:0000305};
DE EC=3.-.-.- {ECO:0000305};
DE AltName: Full=Protein WAVY GROWTH 2 {ECO:0000303|PubMed:15659627};
GN Name=WAV2 {ECO:0000303|PubMed:15659627};
GN OrderedLocusNames=At5g20520 {ECO:0000312|Araport:AT5G20520};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=15659627; DOI=10.1105/tpc.104.028530;
RA Mochizuki S., Harada A., Inada S., Sugimoto-Shirasu K., Stacey N., Wada T.,
RA Ishiguro S., Okada K., Sakai T.;
RT "The Arabidopsis WAVY GROWTH 2 protein modulates root bending in response
RT to environmental stimuli.";
RL Plant Cell 17:537-547(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Involved in the regulation of root growth. Involved in the
CC suppression of the root bending in response to touch stimuli, gravity
CC and light. Regulates negatively stimulus-induced root bending through
CC inhibition of root tip rotation. {ECO:0000269|PubMed:15659627}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15659627};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, rosette leaves, stems and
CC flowers. {ECO:0000269|PubMed:15659627}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant seedlings exhibit enhanced root wavy growth and
CC curvature in response to gravitropism and phototropism.
CC {ECO:0000269|PubMed:15659627}.
CC -!- SIMILARITY: Belongs to the serine esterase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB182157; BAD83800.1; -; mRNA.
DR EMBL; AF296833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92855.1; -; Genomic_DNA.
DR EMBL; AY080751; AAL85997.1; -; mRNA.
DR EMBL; AY114009; AAM45057.1; -; mRNA.
DR EMBL; AY087569; AAM65111.1; -; mRNA.
DR RefSeq; NP_568395.1; NM_122059.4.
DR AlphaFoldDB; Q8RXP6; -.
DR SMR; Q8RXP6; -.
DR IntAct; Q8RXP6; 5.
DR STRING; 3702.AT5G20520.1; -.
DR ESTHER; arath-AT5G20520; ABHD13-BEM46.
DR MEROPS; S09.A24; -.
DR PaxDb; Q8RXP6; -.
DR PRIDE; Q8RXP6; -.
DR ProteomicsDB; 242575; -.
DR EnsemblPlants; AT5G20520.1; AT5G20520.1; AT5G20520.
DR GeneID; 832174; -.
DR Gramene; AT5G20520.1; AT5G20520.1; AT5G20520.
DR KEGG; ath:AT5G20520; -.
DR Araport; AT5G20520; -.
DR TAIR; locus:2149877; AT5G20520.
DR eggNOG; KOG4391; Eukaryota.
DR HOGENOM; CLU_029375_2_0_1; -.
DR InParanoid; Q8RXP6; -.
DR OMA; PNGGHND; -.
DR OrthoDB; 1036130at2759; -.
DR PhylomeDB; Q8RXP6; -.
DR PRO; PR:Q8RXP6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8RXP6; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0019866; C:organelle inner membrane; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IDA:TAIR.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Hydrolase; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..308
FT /note="Alpha/beta hydrolase domain-containing protein WAV2"
FT /id="PRO_0000443503"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 159
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q53547"
FT ACT_SITE 243
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q53547"
FT ACT_SITE 308
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q53547"
SQ SEQUENCE 308 AA; 34341 MW; B0712362175B6A76 CRC64;
MVTYVSALFY GFGGIVVAGV ALLVAFQEKL VYVPVLPGLS KSYPITPARL NLIYEDIWLQ
SSDGVRLHAW FIKMFPECRG PTILFFQENA GNIAHRLEMV RIMIQKLKCN VFMLSYRGYG
ASEGYPSQQG IIKDAQAALD HLSGRTDIDT SRIVVFGRSL GGAVGAVLTK NNPDKVSALI
LENTFTSILD MAGVLLPFLK WFIGGSGTKS LKLLNFVVRS PWKTIDAIAE IKQPVLFLSG
LQDEMVPPFH MKMLYAKAAA RNPQCTFVEF PSGMHMDTWL SGGEVYWKTN LQFLEKYAPE
KRKEDTGR
