WBBL_ECOLI
ID WBBL_ECOLI Reviewed; 264 AA.
AC P36667; O07999; O08000; P76374; P94755;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Rhamnosyltransferase WbbL;
DE EC=2.4.1.-;
GN Name=wbbL; OrderedLocusNames=b4571, JW2016; ORFNames=b2031;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / WG1;
RX PubMed=7512872; DOI=10.1099/13500872-140-1-49;
RA Liu D., Reeves P.R.;
RT "Escherichia coli K12 regains its O antigen.";
RL Microbiology 140:49-57(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=7517390; DOI=10.1128/jb.176.13.4133-4143.1994;
RA Yao Z., Valvano M.A.;
RT "Genetic analysis of the O-specific lipopolysaccharide biosynthesis region
RT (rfb) of Escherichia coli K-12 W3110: identification of genes that confer
RT group 6 specificity to Shigella flexneri serotypes Y and 4a.";
RL J. Bacteriol. 176:4133-4143(1994).
RN [6]
RP FUNCTION AS A RHAMNOSYLTRANSFERASE.
RX PubMed=7517391; DOI=10.1128/jb.176.13.4144-4156.1994;
RA Stevenson G., Neal B., Liu D., Hobbs M., Packer N.H., Batley M.,
RA Redmond J.W., Lindquist L., Reeves P.R.;
RT "Structure of the O antigen of Escherichia coli K-12 and the sequence of
RT its rfb gene cluster.";
RL J. Bacteriol. 176:4144-4156(1994).
CC -!- FUNCTION: Rhamnosyltransferase involved in lipopolysaccharide
CC biosynthesis. {ECO:0000269|PubMed:7517391}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
CC -!- CAUTION: PubMed:9097040, PubMed:9278503 and PubMed:16738553 sequences
CC differ from that shown due to the presence of an IS5I insertion element
CC between codons 148 and 149. {ECO:0000305}.
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DR EMBL; L19537; AAB49382.1; -; Genomic_DNA.
DR EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP009048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U03041; AAC31637.1; -; Genomic_DNA.
DR PIR; I76769; I76769.
DR AlphaFoldDB; P36667; -.
DR IntAct; P36667; 1.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR PRIDE; P36667; -.
DR EchoBASE; EB1929; -.
DR InParanoid; P36667; -.
DR PhylomeDB; P36667; -.
DR BRENDA; 2.4.1.289; 2026.
DR UniPathway; UPA00030; -.
DR PRO; PR:P36667; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016758; F:hexosyltransferase activity; IGI:UniProtKB.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IGI:UniProtKB.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IGI:UniProtKB.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 1: Evidence at protein level;
KW Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW Transferase.
FT CHAIN 1..264
FT /note="Rhamnosyltransferase WbbL"
FT /id="PRO_0000059231"
SQ SEQUENCE 264 AA; 31061 MW; D75F681062AB5D40 CRC64;
MVYIIIVSHG HEDYIKKLLE NLNADDEHYK IIVRDNKDSL LLKQICQHYA GLDYISGGVY
GFGHNNNIAV AYVKEKYRPA DDDYILFLNP DIIMKHDDLL TYIKYVESKR YAFSTLCLFR
DEAKSLHDYS VRKFPVLSDF IVSFMLGINK TKIPKESIYS DTVVDWCAGS FMLVRFSDFV
RVNGFDQGYF MYCEDIDLCL RLSLAGVRLH YVPAFHAIHY AHHDNRSFFS KAFRWHLKST
FRYLARKRIL SNRNFDRISS VFHP
