ID   WBP11_DANRE             Reviewed;         640 AA.
AC   Q6P0D5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=WW domain-binding protein 11;
DE            Short=WBP-11;
GN   Name=wbp11; ORFNames=zgc:77390;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: Activates pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; BC065662; AAH65662.1; -; mRNA.
DR   RefSeq; NP_991215.1; NM_205652.1.
DR   RefSeq; XP_017210366.1; XM_017354877.1.
DR   AlphaFoldDB; Q6P0D5; -.
DR   SMR; Q6P0D5; -.
DR   STRING; 7955.ENSDARP00000019750; -.
DR   iPTMnet; Q6P0D5; -.
DR   GeneID; 110437720; -.
DR   GeneID; 402950; -.
DR   KEGG; dre:110437720; -.
DR   KEGG; dre:402950; -.
DR   CTD; 51729; -.
DR   ZFIN; ZDB-GENE-040426-1829; wbp11.
DR   eggNOG; KOG4672; Eukaryota.
DR   InParanoid; Q6P0D5; -.
DR   OrthoDB; 1240263at2759; -.
DR   Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q6P0D5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR019007; WW_dom-bd_prot_11.
DR   PANTHER; PTHR13361; PTHR13361; 1.
DR   Pfam; PF09429; Wbp11; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Phosphoprotein; Reference proteome; rRNA processing.
FT   CHAIN           1..640
FT                   /note="WW domain-binding protein 11"
FT                   /id="PRO_0000065944"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          75..122
FT                   /evidence="ECO:0000255"
FT   MOTIF           421..432
FT                   /note="PGR"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..208
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..337
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..496
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..601
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         285
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
SQ   SEQUENCE   640 AA;  68823 MW;  95191F8DC32BBFF9 CRC64;
     MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP RQIIRDMEKL
     DEMEFNPVQQ PLLNEKVLRD KRKKLRETFE RIVRLYEREN PETYKELRKL ELEYETKRGQ
     LSLYFDSVKN AESVEVDSIP LPEMPHAPSS ILIQDIPLPG AQPPSILKKS SALGKASSLS
     AAALAGVPRL PAGRKPPGPP PGPPPPQILQ LYGNTRRTEA SAGSDTEMMD GGRDSDSKSE
     ADEESDSQED SSAEREDSDR GERDEERERA DKHTGRSVRF ADMPSPNKKK RRVVKTKSIT
     PLQAMMLRMA GQSVPEEEEE DEEEEYSESE DSEAEDQAST DAPQPLVNPR LPVPSAPMAA
     QQPPSLMQAP PITGPPPLGP PPAPPMRPPG PPSGPPPGPP PGAPPFLRPP GLPSALRGPM
     PRLLPPGPPP GRPPGPPPGP PPGLPPGPPP RGPPPRLPPP APPGMPPPPP PPRAGPPRMA
     PPLSLFPPPL NPNVLSAPPS IVPRQKSPAA SSNEGAPSGS ALQMPPPPGT TANPLAPTIE
     KRATVAGSGG ASAQGGGATI SAKPQIINPK AEVTRFVPTA LRVRRDRAGG TGRREEERPP
     ANQQTPAHQA PPIAHAPTPP NLKTKDQVYE AFMREMEGLL