WBP1L_HUMAN
ID WBP1L_HUMAN Reviewed; 342 AA.
AC Q9NX94; B3KPF4; B7Z6S7; D3DR90; Q1EG70; Q2HIY7; Q5F2G6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=WW domain binding protein 1-like;
DE AltName: Full=Outcome predictor in acute leukemia 1;
GN Name=WBP1L; Synonyms=C10orf26, OPA1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=B-cell lymphoma;
RA Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P.,
RA Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E.,
RA Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A.,
RA Bedrick E., Carroll A.J., Camitta B., Willman C.L.;
RT "Gene expression profiling reveals novel genes for improved risk
RT classification and outcome prediction in pediatric acute lymphoblastic
RT leukemia: identification, validation, and cloning of OPAL1.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP PRO-302 AND SER-320.
RC TISSUE=Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Small intestine;
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9NX94; O95870: ABHD16A; NbExp=3; IntAct=EBI-10316321, EBI-348517;
CC Q9NX94; P55212: CASP6; NbExp=3; IntAct=EBI-10316321, EBI-718729;
CC Q9NX94; P06307: CCK; NbExp=3; IntAct=EBI-10316321, EBI-6624398;
CC Q9NX94; P02489: CRYAA; NbExp=3; IntAct=EBI-10316321, EBI-6875961;
CC Q9NX94; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-10316321, EBI-356015;
CC Q9NX94; P41091: EIF2S3; NbExp=3; IntAct=EBI-10316321, EBI-1054228;
CC Q9NX94; O95208-2: EPN2; NbExp=3; IntAct=EBI-10316321, EBI-12135243;
CC Q9NX94; O75460-2: ERN1; NbExp=3; IntAct=EBI-10316321, EBI-25852368;
CC Q9NX94; P22607: FGFR3; NbExp=3; IntAct=EBI-10316321, EBI-348399;
CC Q9NX94; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-10316321, EBI-10226858;
CC Q9NX94; P21333-2: FLNA; NbExp=3; IntAct=EBI-10316321, EBI-9641086;
CC Q9NX94; Q14957: GRIN2C; NbExp=3; IntAct=EBI-10316321, EBI-8285963;
CC Q9NX94; P06396: GSN; NbExp=3; IntAct=EBI-10316321, EBI-351506;
CC Q9NX94; P54652: HSPA2; NbExp=3; IntAct=EBI-10316321, EBI-356991;
CC Q9NX94; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10316321, EBI-21591415;
CC Q9NX94; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-10316321, EBI-473160;
CC Q9NX94; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-10316321, EBI-5280197;
CC Q9NX94; P62826: RAN; NbExp=3; IntAct=EBI-10316321, EBI-286642;
CC Q9NX94; P49591: SARS1; NbExp=3; IntAct=EBI-10316321, EBI-1053431;
CC Q9NX94; O43765: SGTA; NbExp=3; IntAct=EBI-10316321, EBI-347996;
CC Q9NX94; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10316321, EBI-741480;
CC Q9NX94; Q9Y649; NbExp=3; IntAct=EBI-10316321, EBI-25900580;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NX94-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NX94-2; Sequence=VSP_041670;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91122.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY656171; AAV68559.1; -; mRNA.
DR EMBL; AK000374; BAA91122.1; ALT_INIT; mRNA.
DR EMBL; AK316452; BAH14823.1; -; mRNA.
DR EMBL; AK056285; BAG51666.1; -; mRNA.
DR EMBL; AK300871; BAH13363.1; -; mRNA.
DR EMBL; AL358790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49673.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49674.1; -; Genomic_DNA.
DR EMBL; BC113857; AAI13858.1; -; mRNA.
DR EMBL; BC114465; AAI14466.1; -; mRNA.
DR CCDS; CCDS44473.1; -. [Q9NX94-2]
DR CCDS; CCDS7540.1; -. [Q9NX94-1]
DR RefSeq; NP_001077382.1; NM_001083913.1. [Q9NX94-2]
DR RefSeq; NP_060257.4; NM_017787.4. [Q9NX94-1]
DR AlphaFoldDB; Q9NX94; -.
DR BioGRID; 120189; 7.
DR IntAct; Q9NX94; 24.
DR STRING; 9606.ENSP00000414721; -.
DR iPTMnet; Q9NX94; -.
DR PhosphoSitePlus; Q9NX94; -.
DR BioMuta; WBP1L; -.
DR DMDM; 109820639; -.
DR EPD; Q9NX94; -.
DR jPOST; Q9NX94; -.
DR MassIVE; Q9NX94; -.
DR PaxDb; Q9NX94; -.
DR PeptideAtlas; Q9NX94; -.
DR PRIDE; Q9NX94; -.
DR ProteomicsDB; 83057; -. [Q9NX94-1]
DR ProteomicsDB; 83058; -. [Q9NX94-2]
DR Antibodypedia; 48471; 77 antibodies from 16 providers.
DR DNASU; 54838; -.
DR Ensembl; ENST00000369889.5; ENSP00000358905.4; ENSG00000166272.18. [Q9NX94-1]
DR Ensembl; ENST00000448841.7; ENSP00000414721.1; ENSG00000166272.18. [Q9NX94-2]
DR GeneID; 54838; -.
DR KEGG; hsa:54838; -.
DR MANE-Select; ENST00000448841.7; ENSP00000414721.1; NM_001083913.2; NP_001077382.1. [Q9NX94-2]
DR UCSC; uc001kwe.5; human. [Q9NX94-1]
DR CTD; 54838; -.
DR DisGeNET; 54838; -.
DR GeneCards; WBP1L; -.
DR HGNC; HGNC:23510; WBP1L.
DR HPA; ENSG00000166272; Low tissue specificity.
DR MIM; 611129; gene.
DR neXtProt; NX_Q9NX94; -.
DR OpenTargets; ENSG00000166272; -.
DR PharmGKB; PA128394674; -.
DR VEuPathDB; HostDB:ENSG00000166272; -.
DR eggNOG; ENOG502QQBJ; Eukaryota.
DR GeneTree; ENSGT00950000183109; -.
DR HOGENOM; CLU_046863_0_0_1; -.
DR InParanoid; Q9NX94; -.
DR OMA; CSGLKMG; -.
DR OrthoDB; 732956at2759; -.
DR PhylomeDB; Q9NX94; -.
DR TreeFam; TF330726; -.
DR PathwayCommons; Q9NX94; -.
DR SignaLink; Q9NX94; -.
DR BioGRID-ORCS; 54838; 181 hits in 1081 CRISPR screens.
DR ChiTaRS; WBP1L; human.
DR GeneWiki; C10orf26; -.
DR GenomeRNAi; 54838; -.
DR Pharos; Q9NX94; Tdark.
DR PRO; PR:Q9NX94; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9NX94; protein.
DR Bgee; ENSG00000166272; Expressed in tendon of biceps brachii and 200 other tissues.
DR ExpressionAtlas; Q9NX94; baseline and differential.
DR Genevisible; Q9NX94; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0038160; P:CXCL12-activated CXCR4 signaling pathway; IEA:Ensembl.
DR GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR InterPro; IPR021684; WBP1-like.
DR Pfam; PF11669; WBP-1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..342
FT /note="WW domain binding protein 1-like"
FT /id="PRO_0000241450"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 133..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 173
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..8
FT /note="MPFLLGLR -> MERRRLLGGMALLLLQALPSPLSARAEPP (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041670"
FT VARIANT 302
FT /note="S -> P (in dbSNP:rs284860)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026839"
FT VARIANT 320
FT /note="A -> S (in dbSNP:rs284859)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026840"
FT CONFLICT 90
FT /note="Y -> H (in Ref. 6; AAI13858)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 37828 MW; B8D73B065A2A222B CRC64;
MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT IIIILSCCCV
CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL PNYLLPPYEE VVNRPPTPPP
PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT RGSQGAQSSP LSEPSRSSTR PPSIADPDPS
DLPVDRAATK APGMEPSGSV AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP
GRHRRFTGDS GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC
QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS
