WBP1L_MOUSE
ID WBP1L_MOUSE Reviewed; 348 AA.
AC Q8BGW2; Q3TF48; Q3U3M2; Q6PD43; Q8R0W8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=WW domain binding protein 1-like;
DE AltName: Full=Outcome predictor in acute leukemia 1 homolog;
GN Name=Wbp1l; Synonyms=D19Wsu162e, Opal1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Embryonic gonad, Heart, Kidney, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=FVB/N; TISSUE=Brain, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8BGW2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGW2-2; Sequence=VSP_019442, VSP_041951, VSP_041952;
CC Name=3;
CC IsoId=Q8BGW2-3; Sequence=VSP_019442;
CC Name=4;
CC IsoId=Q8BGW2-4; Sequence=VSP_019443;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH26369.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH58949.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE41050.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AK052400; BAC34974.1; -; mRNA.
DR EMBL; AK078491; BAC37305.1; -; mRNA.
DR EMBL; AK142695; BAE25164.1; -; mRNA.
DR EMBL; AK154686; BAE32763.1; -; mRNA.
DR EMBL; AK169294; BAE41050.1; ALT_SEQ; mRNA.
DR EMBL; BC026369; AAH26369.1; ALT_INIT; mRNA.
DR EMBL; BC058949; AAH58949.1; ALT_INIT; mRNA.
DR CCDS; CCDS29881.2; -. [Q8BGW2-3]
DR CCDS; CCDS50456.1; -. [Q8BGW2-4]
DR CCDS; CCDS50457.1; -. [Q8BGW2-1]
DR RefSeq; NP_001171283.1; NM_001177812.1. [Q8BGW2-4]
DR RefSeq; NP_001171284.1; NM_001177813.1. [Q8BGW2-1]
DR RefSeq; NP_666211.3; NM_146099.3. [Q8BGW2-3]
DR AlphaFoldDB; Q8BGW2; -.
DR BioGRID; 230486; 6.
DR STRING; 10090.ENSMUSP00000096975; -.
DR iPTMnet; Q8BGW2; -.
DR PhosphoSitePlus; Q8BGW2; -.
DR PaxDb; Q8BGW2; -.
DR PRIDE; Q8BGW2; -.
DR ProteomicsDB; 297626; -. [Q8BGW2-1]
DR ProteomicsDB; 297628; -. [Q8BGW2-3]
DR ProteomicsDB; 297629; -. [Q8BGW2-4]
DR Antibodypedia; 48471; 77 antibodies from 16 providers.
DR DNASU; 226178; -.
DR Ensembl; ENSMUST00000099376; ENSMUSP00000096975; ENSMUSG00000047731. [Q8BGW2-4]
DR Ensembl; ENSMUST00000111855; ENSMUSP00000107486; ENSMUSG00000047731. [Q8BGW2-1]
DR Ensembl; ENSMUST00000132202; ENSMUSP00000121821; ENSMUSG00000047731. [Q8BGW2-2]
DR Ensembl; ENSMUST00000138302; ENSMUSP00000117929; ENSMUSG00000047731. [Q8BGW2-3]
DR GeneID; 226178; -.
DR KEGG; mmu:226178; -.
DR UCSC; uc008htw.2; mouse. [Q8BGW2-3]
DR UCSC; uc008htx.2; mouse. [Q8BGW2-4]
DR UCSC; uc008hty.2; mouse. [Q8BGW2-1]
DR CTD; 54838; -.
DR MGI; MGI:107577; Wbp1l.
DR VEuPathDB; HostDB:ENSMUSG00000047731; -.
DR eggNOG; ENOG502QQBJ; Eukaryota.
DR GeneTree; ENSGT00950000183109; -.
DR HOGENOM; CLU_2385571_0_0_1; -.
DR InParanoid; Q8BGW2; -.
DR OMA; CSGLKMG; -.
DR OrthoDB; 732956at2759; -.
DR PhylomeDB; Q8BGW2; -.
DR TreeFam; TF330726; -.
DR BioGRID-ORCS; 226178; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Wbp1l; mouse.
DR PRO; PR:Q8BGW2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BGW2; protein.
DR Bgee; ENSMUSG00000047731; Expressed in ileal epithelium and 256 other tissues.
DR Genevisible; Q8BGW2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:MGI.
DR GO; GO:0038160; P:CXCL12-activated CXCR4 signaling pathway; IMP:MGI.
DR GO; GO:0030097; P:hemopoiesis; IMP:MGI.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:MGI.
DR InterPro; IPR021684; WBP1-like.
DR Pfam; PF11669; WBP-1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..348
FT /note="WW domain binding protein 1-like"
FT /id="PRO_0000241451"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 111..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 177
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NX94"
FT VAR_SEQ 1..8
FT /note="MPFLWGLR -> MERRRLLGGMALLLLQALPSPLSVRAEPP (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019442"
FT VAR_SEQ 1..8
FT /note="MPFLWGLR -> MERRRLLGGMALLLLQALPSPLSVRAEPPQVRLRSQKTVG
FT LVRAY (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019443"
FT VAR_SEQ 44..73
FT /note="WFWLVWTVVIILSCCCVCHHRRAKHRLQAQ -> CKSLSRGFLASQGPGYCL
FT CSLGNRGLASLF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_041951"
FT VAR_SEQ 74..348
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_041952"
FT CONFLICT 150
FT /note="A -> T (in Ref. 2; AAH26369)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 348 AA; 38347 MW; 68FCC6832E852998 CRC64;
MPFLWGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT VVIILSCCCV
CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL PNSLLPPYEE VVNRPPTPPP
PYSAFQLQQQ QQLLPPPPQG GPPGGSPPGA DPPPQGSQGA QSSPLSGPSR SSTRPPSVAD
PQSPEVPTDR EATKASGTES GSPMAGHGEL DPGAFLDQDS ECKEELLKDS RSERGGVSPD
SEDKTPGRHR RFTGDSGIEV CVCNRGHHDD DLKEFNTLID DALDGPLDFC DSCHVRPPVD
EEEGLCLSSE GQAREHGHPH LPRPPACLLL NTINEQDSPN SQHSGSPS
