WBP1_HUMAN
ID WBP1_HUMAN Reviewed; 269 AA.
AC Q96G27; B2RE02; O95637;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=WW domain-binding protein 1;
DE Short=WBP-1;
GN Name=WBP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH YAP1.
RC TISSUE=Lung;
RX PubMed=9202023; DOI=10.1074/jbc.272.27.17070;
RA Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S.,
RA Kelly J.W., Sudol M.;
RT "Characterization of the WW domain of human Yes-associated protein and its
RT polyproline containing ligands.";
RL J. Biol. Chem. 272:17070-17077(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, Eye, Lung, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH WWP1 AND WWP2.
RX PubMed=9169421; DOI=10.1074/jbc.272.23.14611;
RA Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B.,
RA Kay B.K., Fowlkes D.M.;
RT "Identification of novel human WW domain-containing proteins by cloning of
RT ligand targets.";
RL J. Biol. Chem. 272:14611-14616(1997).
RN [6]
RP INTERACTION WITH WWOX, DOMAINS, AND MUTAGENESIS OF TYR-141.
RX PubMed=15064722; DOI=10.1038/sj.onc.1207680;
RA Ludes-Meyers J.H., Kil H., Bednarek A.K., Drake J., Bedford M.T.,
RA Aldaz C.M.;
RT "WWOX binds the specific proline-rich ligand PPXY: identification of
RT candidate interacting proteins.";
RL Oncogene 23:5049-5055(2004).
CC -!- SUBUNIT: Interacts with NEDD4 (By similarity). Binds to the WW domain
CC of YAP1, WWP1 and WWP2. Interacts with WWOX. {ECO:0000250,
CC ECO:0000269|PubMed:15064722, ECO:0000269|PubMed:9169421,
CC ECO:0000269|PubMed:9202023}.
CC -!- INTERACTION:
CC Q96G27; O95208-2: EPN2; NbExp=3; IntAct=EBI-3867685, EBI-12135243;
CC Q96G27; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-3867685, EBI-8640191;
CC Q96G27; Q9NZC7: WWOX; NbExp=3; IntAct=EBI-3867685, EBI-4320739;
CC Q96G27; P46937: YAP1; NbExp=4; IntAct=EBI-3867685, EBI-1044059;
CC Q96G27; O75800: ZMYND10; NbExp=3; IntAct=EBI-3867685, EBI-747061;
CC -!- TISSUE SPECIFICITY: Expressed in most tissues but at significantly
CC lower levels in placenta, lung, liver, and kidney.
CC -!- DOMAIN: The PPxY motif 2 mediates interaction with WWOX. Both PPxY
CC motifs mediate interaction with NEDD4 (By similarity). {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD10950.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U79457; AAD10950.1; ALT_INIT; mRNA.
DR EMBL; AK315745; BAG38099.1; -; mRNA.
DR EMBL; CH471053; EAW99656.1; -; Genomic_DNA.
DR EMBL; BC010012; AAH10012.1; -; mRNA.
DR EMBL; BC064482; AAH64482.1; -; mRNA.
DR EMBL; BC071626; AAH71626.1; -; mRNA.
DR EMBL; BC071850; AAH71850.1; -; mRNA.
DR CCDS; CCDS1943.1; -.
DR RefSeq; NP_036609.1; NM_012477.3.
DR PDB; 1JMQ; NMR; -; P=135-144.
DR PDB; 1K5R; NMR; -; B=135-143.
DR PDBsum; 1JMQ; -.
DR PDBsum; 1K5R; -.
DR AlphaFoldDB; Q96G27; -.
DR SMR; Q96G27; -.
DR BioGRID; 117103; 41.
DR IntAct; Q96G27; 29.
DR MINT; Q96G27; -.
DR STRING; 9606.ENSP00000233615; -.
DR GlyGen; Q96G27; 1 site.
DR iPTMnet; Q96G27; -.
DR PhosphoSitePlus; Q96G27; -.
DR BioMuta; WBP1; -.
DR DMDM; 25091540; -.
DR jPOST; Q96G27; -.
DR MassIVE; Q96G27; -.
DR MaxQB; Q96G27; -.
DR PaxDb; Q96G27; -.
DR PeptideAtlas; Q96G27; -.
DR PRIDE; Q96G27; -.
DR ProteomicsDB; 76588; -.
DR Antibodypedia; 34809; 68 antibodies from 26 providers.
DR DNASU; 23559; -.
DR Ensembl; ENST00000233615.7; ENSP00000233615.2; ENSG00000239779.7.
DR GeneID; 23559; -.
DR KEGG; hsa:23559; -.
DR MANE-Select; ENST00000233615.7; ENSP00000233615.2; NM_012477.4; NP_036609.1.
DR UCSC; uc002slj.3; human.
DR CTD; 23559; -.
DR GeneCards; WBP1; -.
DR HGNC; HGNC:12737; WBP1.
DR HPA; ENSG00000239779; Low tissue specificity.
DR MIM; 606961; gene.
DR neXtProt; NX_Q96G27; -.
DR OpenTargets; ENSG00000239779; -.
DR PharmGKB; PA37348; -.
DR VEuPathDB; HostDB:ENSG00000239779; -.
DR eggNOG; ENOG502RYC0; Eukaryota.
DR GeneTree; ENSGT00950000183109; -.
DR InParanoid; Q96G27; -.
DR OMA; PCEFPVS; -.
DR OrthoDB; 1503326at2759; -.
DR PhylomeDB; Q96G27; -.
DR TreeFam; TF330726; -.
DR PathwayCommons; Q96G27; -.
DR SignaLink; Q96G27; -.
DR BioGRID-ORCS; 23559; 270 hits in 1074 CRISPR screens.
DR ChiTaRS; WBP1; human.
DR GeneWiki; WBP1; -.
DR GenomeRNAi; 23559; -.
DR Pharos; Q96G27; Tbio.
DR PRO; PR:Q96G27; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96G27; protein.
DR Bgee; ENSG00000239779; Expressed in right uterine tube and 93 other tissues.
DR ExpressionAtlas; Q96G27; baseline and differential.
DR Genevisible; Q96G27; HS.
DR GO; GO:0050699; F:WW domain binding; IPI:UniProtKB.
DR InterPro; IPR021684; WBP1-like.
DR Pfam; PF11669; WBP-1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Repeat.
FT CHAIN 1..269
FT /note="WW domain-binding protein 1"
FT /id="PRO_0000065948"
FT REGION 169..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 124..127
FT /note="PPxY motif 1"
FT MOTIF 137..141
FT /note="PPxY motif 2"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 141
FT /note="Y->A: Abolishes interaction with WWOX."
FT /evidence="ECO:0000269|PubMed:15064722"
SQ SEQUENCE 269 AA; 29140 MW; 009CF5A444E62AC0 CRC64;
MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC TYYYELWWFW
LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG ACHGAGPFPT GSLLDLRFLS
TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ
SAPPHQEGEP GAGVTPASTP PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL
EDYSPCALPP ESVPQIFPMG LSSSEGDIP
