WBP1_MOUSE
ID WBP1_MOUSE Reviewed; 304 AA.
AC P97764; Q8WUP5; Q99J20;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=WW domain-binding protein 1;
DE Short=WBP-1;
GN Name=Wbp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH YAP1.
RX PubMed=7644498; DOI=10.1073/pnas.92.17.7819;
RA Chen H.I., Sudol M.;
RT "The WW domain of Yes-associated protein binds a proline-rich ligand that
RT differs from the consensus established for Src homology 3-binding
RT modules.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:7819-7823(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH NEDD4, DOMAINS, AND MUTAGENESIS OF TYR-162 AND TYR-176.
RC TISSUE=Embryo;
RX PubMed=11042109; DOI=10.1042/bj3510557;
RA Jolliffe C.N., Harvey K.F., Haines B.P., Parasivam G., Kumar S.;
RT "Identification of multiple proteins expressed in murine embryos as binding
RT partners for the WW domains of the ubiquitin-protein ligase Nedd4.";
RL Biochem. J. 351:557-565(2000).
CC -!- SUBUNIT: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with
CC WWOX (By similarity). Interacts with NEDD4. {ECO:0000250,
CC ECO:0000269|PubMed:11042109, ECO:0000269|PubMed:7644498}.
CC -!- INTERACTION:
CC P97764; P46935: Nedd4; NbExp=3; IntAct=EBI-6304160, EBI-773516;
CC P97764; P46937: YAP1; Xeno; NbExp=13; IntAct=EBI-6304160, EBI-1044059;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P97764-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P97764-2; Sequence=VSP_004022;
CC -!- DOMAIN: The PPxY motif 2 mediates interaction with WWOX (By
CC similarity). Both PPxY motifs mediate interaction with NEDD4.
CC {ECO:0000250, ECO:0000269|PubMed:11042109}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U40825; AAB40892.1; -; mRNA.
DR EMBL; BC005666; AAH05666.1; -; mRNA.
DR EMBL; BC019889; AAH19889.1; -; mRNA.
DR CCDS; CCDS39528.1; -. [P97764-2]
DR CCDS; CCDS39529.1; -. [P97764-1]
DR RefSeq; NP_001077392.1; NM_001083923.1. [P97764-2]
DR RefSeq; NP_058037.2; NM_016757.2. [P97764-1]
DR AlphaFoldDB; P97764; -.
DR BioGRID; 204545; 2.
DR ELM; P97764; -.
DR IntAct; P97764; 2.
DR MINT; P97764; -.
DR STRING; 10090.ENSMUSP00000032111; -.
DR PhosphoSitePlus; P97764; -.
DR PaxDb; P97764; -.
DR PRIDE; P97764; -.
DR Antibodypedia; 34809; 68 antibodies from 26 providers.
DR DNASU; 22377; -.
DR Ensembl; ENSMUST00000032111; ENSMUSP00000032111; ENSMUSG00000030035. [P97764-1]
DR Ensembl; ENSMUST00000113936; ENSMUSP00000109569; ENSMUSG00000030035. [P97764-2]
DR GeneID; 22377; -.
DR KEGG; mmu:22377; -.
DR UCSC; uc009cmo.1; mouse. [P97764-1]
DR UCSC; uc009cmq.1; mouse. [P97764-2]
DR CTD; 23559; -.
DR MGI; MGI:104710; Wbp1.
DR VEuPathDB; HostDB:ENSMUSG00000030035; -.
DR eggNOG; ENOG502RYC0; Eukaryota.
DR GeneTree; ENSGT00950000183109; -.
DR InParanoid; P97764; -.
DR OMA; PCEFPVS; -.
DR PhylomeDB; P97764; -.
DR TreeFam; TF330726; -.
DR BioGRID-ORCS; 22377; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Wbp1; mouse.
DR PRO; PR:P97764; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P97764; protein.
DR Bgee; ENSMUSG00000030035; Expressed in cortical plate and 266 other tissues.
DR ExpressionAtlas; P97764; baseline and differential.
DR Genevisible; P97764; MM.
DR GO; GO:0050699; F:WW domain binding; IPI:UniProtKB.
DR InterPro; IPR021684; WBP1-like.
DR Pfam; PF11669; WBP-1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..304
FT /note="WW domain-binding protein 1"
FT /id="PRO_0000065949"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 159..162
FT /note="PPxY motif 1"
FT MOTIF 172..176
FT /note="PPxY motif 2"
FT COMPBIAS 206..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 24..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_004022"
FT MUTAGEN 162
FT /note="Y->A: Abolishes interaction with NEDD4."
FT /evidence="ECO:0000269|PubMed:11042109"
FT MUTAGEN 176
FT /note="Y->A: Abolishes interaction with NEDD4."
FT /evidence="ECO:0000269|PubMed:11042109"
FT CONFLICT 302..304
FT /note="DIP -> TSHK (in Ref. 1; AAB40892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 33165 MW; 2A5C95D34D9D7520 CRC64;
MARASSRNSS EEAWGSLQAP QQQQSPAASS LEGAIWRRAG TQTRALDTIL YHPQQSHLLR
ELCPGVNTQP YLCETGHCCG ETGCCTYYYE LWWFWLLWTV LILFSCCCAF RHRRAKLRLQ
QQQRQREINL LAYHGACHGA GPVPTGSLLD LRLLSAFKPP AYEDVVHHPG TPPPPYTVGP
GYPWTTSSEC TRCSSESSCS AHLEGTNVEG VSSQQSALPH QEGEPRAGLS PVHIPPSCRY
RRLTGDSGIE LCPCPDSSEG EPLKEARASA SQPDLEDHSP CALPPDSVSQ VPPMGLASSC
GDIP
