ID   WBP2L_BOVIN             Reviewed;         313 AA.
AC   A3KFF6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Postacrosomal sheath WW domain-binding protein;
DE   AltName: Full=WW domain-binding protein 2-like;
GN   Name=WBP2NL; Synonyms=PAWP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND MOTIF.
RC   TISSUE=Sperm;
RX   PubMed=17289678; DOI=10.1074/jbc.m609132200;
RA   Wu A.T.H., Sutovsky P., Manandhar G., Xu W., Katayama M., Day B.N.,
RA   Park K.-W., Yi Y.-J., Xi Y.W., Prather R.S., Oko R.;
RT   "PAWP, a sperm-specific WW domain-binding protein, promotes meiotic
RT   resumption and pronuclear development during fertilization.";
RL   J. Biol. Chem. 282:12164-12175(2007).
CC   -!- FUNCTION: May play a role in meiotic resumption and pronuclear
CC       formation, mediated by a WW domain-signaling pathway during
CC       fertilization. {ECO:0000269|PubMed:17289678}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:17289678}.
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DR   EMBL; AF322215; AAQ14855.1; -; mRNA.
DR   RefSeq; NP_001075910.1; NM_001082441.1.
DR   AlphaFoldDB; A3KFF6; -.
DR   STRING; 9913.ENSBTAP00000017533; -.
DR   PaxDb; A3KFF6; -.
DR   Ensembl; ENSBTAT00000017533; ENSBTAP00000017533; ENSBTAG00000013174.
DR   GeneID; 523070; -.
DR   KEGG; bta:523070; -.
DR   CTD; 164684; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013174; -.
DR   VGNC; VGNC:36873; WBP2NL.
DR   eggNOG; KOG3294; Eukaryota.
DR   GeneTree; ENSGT00530000063718; -.
DR   HOGENOM; CLU_057206_2_0_1; -.
DR   InParanoid; A3KFF6; -.
DR   OMA; AVNQNHT; -.
DR   OrthoDB; 1513129at2759; -.
DR   TreeFam; TF314141; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000013174; Expressed in semen and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0033011; C:perinuclear theca; IDA:HGNC-UCL.
DR   GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR   GO; GO:0061827; C:sperm head; IEA:Ensembl.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0050699; F:WW domain binding; IDA:HGNC-UCL.
DR   GO; GO:0007343; P:egg activation; IDA:HGNC-UCL.
DR   GO; GO:0035038; P:female pronucleus assembly; IDA:MGI.
DR   GO; GO:0035039; P:male pronucleus assembly; IDA:HGNC-UCL.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR044852; WBP2-like.
DR   InterPro; IPR033597; WBP2NL.
DR   PANTHER; PTHR31606; PTHR31606; 2.
DR   PANTHER; PTHR31606:SF2; PTHR31606:SF2; 2.
DR   Pfam; PF02893; GRAM; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..313
FT                   /note="Postacrosomal sheath WW domain-binding protein"
FT                   /id="PRO_0000289126"
FT   DOMAIN          8..87
FT                   /note="GRAM"
FT   REPEAT          179..185
FT                   /note="1"
FT   REPEAT          193..199
FT                   /note="2"
FT   REPEAT          207..213
FT                   /note="3"
FT   REPEAT          214..220
FT                   /note="4"
FT   REPEAT          221..227
FT                   /note="5"
FT   REPEAT          228..234
FT                   /note="6"
FT   REPEAT          235..241
FT                   /note="7"
FT   REPEAT          242..248
FT                   /note="8"
FT   REPEAT          249..255
FT                   /note="9"
FT   REPEAT          256..262
FT                   /note="10"
FT   REPEAT          263..269
FT                   /note="11"
FT   REPEAT          270..276
FT                   /note="12"
FT   REGION          179..276
FT                   /note="12 X 7 AA tandem repeat of Y-G-X-P-P-X-G"
FT   REGION          254..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           183..186
FT                   /note="PPxY motif 1"
FT   MOTIF           281..284
FT                   /note="PPxY motif 2"
FT   COMPBIAS        291..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  31966 MW;  B700DD904B7D456B CRC64;
     MAVNQSHTES RRGALIPSGE SVLKQCEDVD LCFLQKPVES YLFNGTKKGT LFLTSYRVVF
     VTSHLVNDPM LSFMMPFGLM SDCTIEQPIF APNYIKGTIQ AAPGGGWEGQ AVFKLSFRKG
     GAIEFAQLMV KAASAAARGI PLGSVNYWFD TSGLYIITVP GAAVCSSQTP CPAYPIVIYG
     PPPPGYTVQP GEYGTPPEGY GAQPGGYGAP PMGYGAPPVG YGVPPGGYGV PPGGYGVPPG
     GYGAPPGGYG VPPGGYGAPP GGYGAPPAGY GAPPAGNEAL PPAYEAPSAG NTAASHRSMT
     AQQETSLPTT SSS