WBP2L_HUMAN
ID WBP2L_HUMAN Reviewed; 309 AA.
AC Q6ICG8; A3KFF7; A8MSG5; B3KXX4; Q8TBF0; Q8TBF3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Postacrosomal sheath WW domain-binding protein;
DE AltName: Full=WW domain-binding protein 2-like;
GN Name=WBP2NL; Synonyms=PAWP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-121 AND HIS-285.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 75-309, TISSUE SPECIFICITY, AND MOTIF.
RX PubMed=17289678; DOI=10.1074/jbc.m609132200;
RA Wu A.T.H., Sutovsky P., Manandhar G., Xu W., Katayama M., Day B.N.,
RA Park K.-W., Yi Y.-J., Xi Y.W., Prather R.S., Oko R.;
RT "PAWP, a sperm-specific WW domain-binding protein, promotes meiotic
RT resumption and pronuclear development during fertilization.";
RL J. Biol. Chem. 282:12164-12175(2007).
CC -!- FUNCTION: May play a role in meiotic resumption and pronuclear
CC formation, mediated by a WW domain-signaling pathway during
CC fertilization. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ICG8; Q8IXW7: FMR1; NbExp=3; IntAct=EBI-17769315, EBI-11976595;
CC Q6ICG8; P13473-2: LAMP2; NbExp=3; IntAct=EBI-17769315, EBI-21591415;
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:17289678}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22549.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CR456400; CAG30286.1; -; mRNA.
DR EMBL; AK128138; BAG54636.1; -; mRNA.
DR EMBL; Z99716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022546; AAH22546.1; -; mRNA.
DR EMBL; BC022549; AAH22549.1; ALT_FRAME; mRNA.
DR EMBL; AF393575; AAQ02873.1; -; mRNA.
DR CCDS; CCDS14029.1; -.
DR RefSeq; NP_689826.2; NM_152613.2.
DR AlphaFoldDB; Q6ICG8; -.
DR SMR; Q6ICG8; -.
DR BioGRID; 127900; 12.
DR IntAct; Q6ICG8; 8.
DR STRING; 9606.ENSP00000332983; -.
DR iPTMnet; Q6ICG8; -.
DR PhosphoSitePlus; Q6ICG8; -.
DR BioMuta; WBP2NL; -.
DR DMDM; 74757724; -.
DR MassIVE; Q6ICG8; -.
DR PaxDb; Q6ICG8; -.
DR PeptideAtlas; Q6ICG8; -.
DR PRIDE; Q6ICG8; -.
DR ProteomicsDB; 66390; -.
DR Antibodypedia; 27190; 99 antibodies from 19 providers.
DR DNASU; 164684; -.
DR Ensembl; ENST00000328823.13; ENSP00000332983.9; ENSG00000183066.14.
DR Ensembl; ENST00000329620.9; ENSP00000328800.5; ENSG00000183066.14.
DR Ensembl; ENST00000436265.5; ENSP00000401002.1; ENSG00000183066.14.
DR GeneID; 164684; -.
DR KEGG; hsa:164684; -.
DR MANE-Select; ENST00000328823.13; ENSP00000332983.9; NM_152613.3; NP_689826.2.
DR UCSC; uc003bbt.4; human.
DR CTD; 164684; -.
DR DisGeNET; 164684; -.
DR GeneCards; WBP2NL; -.
DR HGNC; HGNC:28389; WBP2NL.
DR HPA; ENSG00000183066; Tissue enriched (testis).
DR MIM; 610981; gene.
DR neXtProt; NX_Q6ICG8; -.
DR OpenTargets; ENSG00000183066; -.
DR PharmGKB; PA145147710; -.
DR VEuPathDB; HostDB:ENSG00000183066; -.
DR eggNOG; KOG3294; Eukaryota.
DR GeneTree; ENSGT00530000063718; -.
DR InParanoid; Q6ICG8; -.
DR OMA; AVNQNHT; -.
DR OrthoDB; 1513129at2759; -.
DR PhylomeDB; Q6ICG8; -.
DR TreeFam; TF314141; -.
DR PathwayCommons; Q6ICG8; -.
DR SignaLink; Q6ICG8; -.
DR BioGRID-ORCS; 164684; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; WBP2NL; human.
DR GenomeRNAi; 164684; -.
DR Pharos; Q6ICG8; Tbio.
DR PRO; PR:Q6ICG8; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6ICG8; protein.
DR Bgee; ENSG00000183066; Expressed in left testis and 95 other tissues.
DR ExpressionAtlas; Q6ICG8; baseline and differential.
DR Genevisible; Q6ICG8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0033011; C:perinuclear theca; ISS:HGNC-UCL.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0061827; C:sperm head; IDA:UniProtKB.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; ISS:HGNC-UCL.
DR GO; GO:0007343; P:egg activation; ISS:HGNC-UCL.
DR GO; GO:0035038; P:female pronucleus assembly; IEA:InterPro.
DR GO; GO:0035039; P:male pronucleus assembly; ISS:HGNC-UCL.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR044852; WBP2-like.
DR InterPro; IPR033597; WBP2NL.
DR PANTHER; PTHR31606; PTHR31606; 2.
DR PANTHER; PTHR31606:SF2; PTHR31606:SF2; 2.
DR Pfam; PF02893; GRAM; 1.
PE 1: Evidence at protein level;
KW Meiosis; Reference proteome; Repeat.
FT CHAIN 1..309
FT /note="Postacrosomal sheath WW domain-binding protein"
FT /id="PRO_0000289127"
FT DOMAIN 45..87
FT /note="GRAM"
FT REPEAT 175..181
FT /note="1"
FT REPEAT 182..188
FT /note="2"
FT REPEAT 189..195
FT /note="3"
FT REPEAT 217..223
FT /note="4"
FT REPEAT 224..230
FT /note="5"
FT REPEAT 231..237
FT /note="6"
FT REPEAT 238..244
FT /note="7"
FT REPEAT 245..251
FT /note="8"
FT REPEAT 252..258
FT /note="9"
FT REPEAT 259..265
FT /note="10"
FT REGION 175..265
FT /note="10 X 7 AA tandem repeat of Y-G-X-P-P-X-G"
FT REGION 251..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 186..189
FT /note="PPxY motif"
FT COMPBIAS 281..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 5
FT /note="Q -> E (in dbSNP:rs17002790)"
FT /id="VAR_032578"
FT VARIANT 121
FT /note="D -> G (in dbSNP:rs133335)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032579"
FT VARIANT 170
FT /note="C -> F (in dbSNP:rs17002802)"
FT /id="VAR_032580"
FT VARIANT 285
FT /note="Q -> H (in dbSNP:rs2301521)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032581"
FT CONFLICT 136
FT /note="A -> V (in Ref. 5; AAQ02873)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 31909 MW; D09202E9A951DF48 CRC64;
MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT LFLTSYRVIF
ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ AAPYGGWEGQ ATFKLVFRNG
DAIEFAQLMV KAASAAARGF PLRTLNDWFS SMGIYVITGE GNMCTPQMPC SVIVYGAPPA
GYGAPPPGYG APPAGYGAQP VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA
PPLGYGTPPL GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP
SASSSQVHS
