WBP2L_MOUSE
ID WBP2L_MOUSE Reviewed; 359 AA.
AC Q9D529;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Postacrosomal sheath WW domain-binding protein;
DE AltName: Full=WW domain-binding protein 2-like;
GN Name=Wbp2nl; Synonyms=Pawp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND MOTIF.
RX PubMed=17289678; DOI=10.1074/jbc.m609132200;
RA Wu A.T.H., Sutovsky P., Manandhar G., Xu W., Katayama M., Day B.N.,
RA Park K.-W., Yi Y.-J., Xi Y.W., Prather R.S., Oko R.;
RT "PAWP, a sperm-specific WW domain-binding protein, promotes meiotic
RT resumption and pronuclear development during fertilization.";
RL J. Biol. Chem. 282:12164-12175(2007).
CC -!- FUNCTION: May play a role in meiotic resumption and pronuclear
CC formation, mediated by a WW domain-signaling pathway during
CC fertilization. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:17289678}.
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DR EMBL; AK015863; BAB30005.1; -; mRNA.
DR EMBL; BC119520; AAI19521.1; -; mRNA.
DR CCDS; CCDS37158.1; -.
DR RefSeq; NP_083342.1; NM_029066.1.
DR AlphaFoldDB; Q9D529; -.
DR STRING; 10090.ENSMUSP00000023089; -.
DR PhosphoSitePlus; Q9D529; -.
DR PaxDb; Q9D529; -.
DR PRIDE; Q9D529; -.
DR ProteomicsDB; 297890; -.
DR Antibodypedia; 27190; 99 antibodies from 19 providers.
DR Ensembl; ENSMUST00000023089; ENSMUSP00000023089; ENSMUSG00000022455.
DR GeneID; 74716; -.
DR KEGG; mmu:74716; -.
DR UCSC; uc007wyv.1; mouse.
DR CTD; 164684; -.
DR MGI; MGI:1921966; Wbp2nl.
DR VEuPathDB; HostDB:ENSMUSG00000022455; -.
DR eggNOG; KOG3294; Eukaryota.
DR GeneTree; ENSGT00530000063718; -.
DR HOGENOM; CLU_057206_2_0_1; -.
DR InParanoid; Q9D529; -.
DR OMA; AVNQNHT; -.
DR OrthoDB; 1513129at2759; -.
DR PhylomeDB; Q9D529; -.
DR TreeFam; TF314141; -.
DR BioGRID-ORCS; 74716; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Wbp2nl; mouse.
DR PRO; PR:Q9D529; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D529; protein.
DR Bgee; ENSMUSG00000022455; Expressed in seminiferous tubule of testis and 23 other tissues.
DR Genevisible; Q9D529; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0033011; C:perinuclear theca; ISS:HGNC-UCL.
DR GO; GO:0036126; C:sperm flagellum; ISO:MGI.
DR GO; GO:0061827; C:sperm head; ISO:MGI.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; ISS:HGNC-UCL.
DR GO; GO:0007343; P:egg activation; ISS:HGNC-UCL.
DR GO; GO:0035038; P:female pronucleus assembly; ISO:MGI.
DR GO; GO:0035039; P:male pronucleus assembly; ISS:HGNC-UCL.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR044852; WBP2-like.
DR InterPro; IPR033597; WBP2NL.
DR PANTHER; PTHR31606; PTHR31606; 2.
DR PANTHER; PTHR31606:SF2; PTHR31606:SF2; 2.
DR Pfam; PF02893; GRAM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..359
FT /note="Postacrosomal sheath WW domain-binding protein"
FT /id="PRO_0000289128"
FT DOMAIN 16..87
FT /note="GRAM"
FT REPEAT 173..179
FT /note="1"
FT REPEAT 194..200
FT /note="2"
FT REPEAT 201..207
FT /note="3"
FT REPEAT 241..247
FT /note="4"
FT REPEAT 255..261
FT /note="5"
FT REPEAT 297..303
FT /note="6"
FT REGION 173..303
FT /note="6 X 7 AA tandem repeat of Y-G-X-P-P-X-G"
FT REGION 252..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 219..222
FT /note="PPxY motif 1"
FT MOTIF 231..234
FT /note="PPxY motif 2"
FT MOTIF 245..248
FT /note="PPxY motif 3"
FT MOTIF 259..262
FT /note="PPxY motif 4"
FT MOTIF 273..276
FT /note="PPxY motif 5"
FT MOTIF 287..290
FT /note="PPxY motif 6"
FT COMPBIAS 336..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 37485 MW; 72A0D75EAF1A63E7 CRC64;
MAVNQNHTVD RRWAAIPHGE SLLKKCSEVD LSFPQSPPGS NLFSGTKRGA LFLTSYRVIF
VTSRADNDPM FSFTMPFHLM NNCTVEQPIF GANYIKGTIQ AAPDGGWEGS ATFKIVFRKG
GAIDFAQLMA KAASAAAQGV PLRVASFWMG PLGIYVITGD RNMYAPQAYQ VAYGAPPAGY
GASPVGYGVP SAGYGAPPAG YGAPPVGYVA PSPGYDVLPP GYGAVRYGSP PPLYVATPMG
YGVPPPGYGP PPVRYGSPPP GYEAPTMEYG AQPPRYGTTP MGSGSPPPRY EAPPMGYGTP
PSGRESIPPG SRATSVAQEA PPAGSEAGHP MSVAVQNPEF QASFPSTSSS QVHSPRSKM
