WBP2_RAT
ID WBP2_RAT Reviewed; 262 AA.
AC Q8R478;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=WW domain-binding protein 2;
DE Short=WBP-2;
GN Name=Wbp2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zannini M., Nitsch R.;
RT "Isolation of the cDNA encoding for rat Wbp2.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as transcriptional coactivator of estrogen and
CC progesterone receptors (ESR1 and PGR) upon hormone activation. In
CC presence of estrogen, binds to ESR1-responsive promoters. Required for
CC YAP1 coactivation function on PGR activity. Synergizes with WBP2 in
CC enhancing PGR activity (By similarity). Modulates expression of post-
CC synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By
CC similarity). {ECO:0000250|UniProtKB:P97765,
CC ECO:0000250|UniProtKB:Q969T9}.
CC -!- SUBUNIT: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with
CC NEDD4 (By similarity). Interacts with ESR1 and UBE3A (By similarity).
CC {ECO:0000250|UniProtKB:P97765, ECO:0000250|UniProtKB:Q969T9}.
CC -!- INTERACTION:
CC Q8R478; P51974: Pax8; NbExp=4; IntAct=EBI-1223229, EBI-1223113;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969T9}. Nucleus
CC {ECO:0000250|UniProtKB:Q969T9}. Note=Translocates from cytoplasm to
CC nucleus when phosphorylated. {ECO:0000250|UniProtKB:Q969T9}.
CC -!- DOMAIN: The PPxY motif 1 mediates interaction with NEDD4 (By
CC similarity). The PPxY motif 2 is required for the coactivation function
CC (By similarity). {ECO:0000250|UniProtKB:P97765,
CC ECO:0000250|UniProtKB:Q969T9}.
CC -!- PTM: Phosphorylated in repsonse to EGF as well as estrogen and
CC progesterone hormones. Tyr-192 and Tyr-232 are phosphorylated by YES
CC and SRC inducing nuclear translocation. {ECO:0000250|UniProtKB:Q969T9}.
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DR EMBL; AF499026; AAM18132.1; -; mRNA.
DR RefSeq; NP_620431.1; NM_138975.1.
DR AlphaFoldDB; Q8R478; -.
DR IntAct; Q8R478; 1.
DR STRING; 10116.ENSRNOP00000010826; -.
DR PhosphoSitePlus; Q8R478; -.
DR jPOST; Q8R478; -.
DR PaxDb; Q8R478; -.
DR PRIDE; Q8R478; -.
DR GeneID; 192645; -.
DR KEGG; rno:192645; -.
DR CTD; 23558; -.
DR RGD; 620032; Wbp2.
DR eggNOG; KOG3294; Eukaryota.
DR InParanoid; Q8R478; -.
DR OrthoDB; 1513129at2759; -.
DR PRO; PR:Q8R478; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0000785; C:chromatin; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0031490; F:chromatin DNA binding; ISO:RGD.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0071391; P:cellular response to estrogen stimulus; ISO:RGD.
DR GO; GO:0045815; P:epigenetic maintenance of chromatin in transcription-competent conformation; ISO:RGD.
DR GO; GO:0045184; P:establishment of protein localization; ISO:RGD.
DR GO; GO:0071169; P:establishment of protein localization to chromatin; ISO:RGD.
DR GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; ISO:RGD.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0050847; P:progesterone receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR GO; GO:0032570; P:response to progesterone; ISS:UniProtKB.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR033598; WBP2.
DR InterPro; IPR044852; WBP2-like.
DR PANTHER; PTHR31606; PTHR31606; 1.
DR PANTHER; PTHR31606:SF4; PTHR31606:SF4; 1.
DR Pfam; PF02893; GRAM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..262
FT /note="WW domain-binding protein 2"
FT /id="PRO_0000065952"
FT DOMAIN 1..84
FT /note="GRAM"
FT REGION 197..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 196..200
FT /note="PPxY motif 1"
FT MOTIF 249..253
FT /note="PPxY motif 2"
FT COMPBIAS 197..214
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 192
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q969T9"
FT MOD_RES 232
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q969T9"
SQ SEQUENCE 262 AA; 28131 MW; 895CE2DB5F8FE448 CRC64;
MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL
SKGKDAMRSF MMPFYLMKDC EVKQPVFGAN FIKGTVKAEA GGGWEGSASY KLTFTAGGAI
EFGQQMLQVA SQASRGEVPN GAYGYPYMPS GAYVFPPPVA NGMYPCPPGY PYPPPPPEFY
PGPPMMDGAM GYVQPPPPPY PGPMEPPVVS GPSAPPTPAA EAKAAEAAAS AYYNPGNPHN
VYMPTSQPPP PPYYPPEDKK TQ
