WC11_BOVIN
ID WC11_BOVIN Reviewed; 1436 AA.
AC P30205;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Antigen WC1.1;
DE Flags: Precursor;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RX PubMed=1431105;
RA Wijngaard P.L.J., Metzelaar M.J., Machugh N.D., Morrison W.I.,
RA Clevers H.C.;
RT "Molecular characterization of the WC1 antigen expressed specifically on
RT bovine CD4-CD8-gamma delta T lymphocytes.";
RL J. Immunol. 149:3273-3277(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=7511649;
RA Wijngaard P.L.J., MacHugh N.D., Metzelaar M.J., Romberg S., Bensaid A.,
RA Pepin L., Davis W.C., Clevers H.C.;
RT "Members of the novel WC1 gene family are differentially expressed on
RT subsets of bovine CD4-CD8- gamma delta T lymphocytes.";
RL J. Immunol. 152:3476-3482(1994).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed on subsets of CD4-CD8- gamma delta T
CC lymphocytes. {ECO:0000269|PubMed:7511649}.
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DR EMBL; X63723; CAA45255.1; -; mRNA.
DR PIR; A46496; A46496.
DR RefSeq; NP_788824.1; NM_176651.1.
DR AlphaFoldDB; P30205; -.
DR SMR; P30205; -.
DR STRING; 9913.ENSBTAP00000052853; -.
DR iPTMnet; P30205; -.
DR PaxDb; P30205; -.
DR PRIDE; P30205; -.
DR GeneID; 338056; -.
DR KEGG; bta:338056; -.
DR CTD; 283316; -.
DR eggNOG; ENOG502QQ5W; Eukaryota.
DR OrthoDB; 1095487at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 3.10.250.10; -; 11.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF00530; SRCR; 11.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 11.
DR SUPFAM; SSF56487; SSF56487; 11.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 11.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..1436
FT /note="Antigen WC1.1"
FT /id="PRO_0000033229"
FT DOMAIN 28..131
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 134..234
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 239..340
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 376..476
FT /note="SRCR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 481..581
FT /note="SRCR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 586..686
FT /note="SRCR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 689..789
FT /note="SRCR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 794..895
FT /note="SRCR 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 931..1031
FT /note="SRCR 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 1036..1136
FT /note="SRCR 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 1155..1255
FT /note="SRCR 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT REGION 1337..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 244
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 444
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 499
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 531
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 717
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 799
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 897
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 979
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 999
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1054
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1086
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 66..130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 97..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 172..233
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 203..213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 265..329
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 278..339
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 309..319
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 401..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 414..475
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 445..455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 506..570
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 519..580
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 550..560
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 611..675
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 624..685
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 655..665
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 727..788
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 758..768
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 820..884
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 833..894
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 864..874
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 956..1020
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 969..1030
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1000..1010
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1061..1125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1074..1135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1105..1115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1180..1244
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1193..1254
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1224..1234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1436 AA; 154197 MW; 6C72E5FDC6BA088C CRC64;
MALGRHLSLR GLCVLLLGTM VGGQALELRL KDGVHRCEGR VEVKHQGEWG TVDGYRWTLK
DASVVCRQLG CGAAIGFPGG AYFGPGLGPI WLLYTSCEGT ESTVSDCEHS NIKDYRNDGY
NHGRDAGVVC SGFVRLAGGD GPCSGRVEVH SGEAWIPVSD GNFTLATAQI ICAELGCGKA
VSVLGHELFR ESSAQVWAEE FRCEGEEPEL WVCPRVPCPG GTCHHSGSAQ VVCSAYSEVR
LMTNGSSQCE GQVEMNISGQ WRALCASHWS LANANVICRQ LGCGVAISTP GGPHLVEEGD
QILTARFHCS GAESFLWSCP VTALGGPDCS HGNTASVICS GNQIQVLPQC NDSVSQPTGS
AASEDSAPYC SDSRQLRLVD GGGPCAGRVE ILDQGSWGTI CDDGWDLDDA RVVCRQLGCG
EALNATGSAH FGAGSGPIWL DNLNCTGKES HVWRCPSRGW GQHNCRHKQD AGVICSEFLA
LRMVSEDQQC AGWLEVFYNG TWGSVCRNPM EDITVSTICR QLGCGDSGTL NSSVALREGF
RPQWVDRIQC RKTDTSLWQC PSDPWNYNSC SPKEEAYIWC ADSRQIRLVD GGGRCSGRVE
ILDQGSWGTI CDDRWDLDDA RVVCKQLGCG EALDATVSSF FGTGSGPIWL DEVNCRGEES
QVWRCPSWGW RQHNCNHQED AGVICSGFVR LAGGDGPCSG RVEVHSGEAW TPVSDGNFTL
PTAQVICAEL GCGKAVSVLG HMPFRESDGQ VWAEEFRCDG GEPELWSCPR VPCPGGTCLH
SGAAQVVCSV YTEVQLMKNG TSQCEGQVEM KISGRWRALC ASHWSLANAN VVCRQLGCGV
AISTPRGPHL VEGGDQISTA QFHCSGAESF LWSCPVTALG GPDCSHGNTA SVICSGNHTQ
VLPQCNDFLS QPAGSAASEE SSPYCSDSRQ LRLVDGGGPC GGRVEILDQG SWGTICDDDW
DLDDARVVCR QLGCGEALNA TGSAHFGAGS GPIWLDDLNC TGKESHVWRC PSRGWGRHDC
RHKEDAGVIC SEFLALRMVS EDQQCAGWLE VFYNGTWGSV CRSPMEDITV SVICRQLGCG
DSGSLNTSVG LREGSRPRWV DLIQCRKMDT SLWQCPSGPW KYSSCSPKEE AYISCEGRRP
KSCPTAAACT DREKLRLRGG DSECSGRVEV WHNGSWGTVC DDSWSLAEAE VVCQQLGCGQ
ALEAVRSAAF GPGNGSIWLD EVQCGGRESS LWDCVAEPWG QSDCKHEEDA GVRCSGVRTT
LPTTTAGTRT TSNSLPGIFS LPGVLCLILG SLLFLVLVIL VTQLLRWRAE RRALSSYEDA
LAEAVYEELD YLLTQKEGLG SPDQMTDVPD ENYDDAEEVP VPGTPSPSQG NEEEVPPEKE
DGVRSSQTGS FLNFSREAAN PGEGEESFWL LQGKKGDAGY DDVELSALGT SPVTFS
