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WC1_NEUCR
ID   WC1_NEUCR               Reviewed;        1167 AA.
AC   Q01371; Q7RVA7; V5IKL6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=White collar 1 protein;
DE            Short=WC1;
GN   Name=wc-1; ORFNames=NCU02356;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=8612589; DOI=10.1002/j.1460-2075.1996.tb00510.x;
RA   Ballario P., Vittorioso P., Magrelli A., Talora C., Cabibbo A., Macino G.;
RT   "White collar-1, a central regulator of blue light responses in Neurospora,
RT   is a zinc finger protein.";
RL   EMBO J. 15:1650-1657(1996).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Ballario P.;
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May function as a transcription factor involved in light
CC       regulation. Binds and affects blue light regulation of the al-3 gene.
CC       Wc-1 and wc-2 proteins interact via homologous PAS domains, bind to
CC       promoters of light regulated genes such as frq, and activate
CC       transcription.
CC   -!- SUBUNIT: Heterodimer of wc-1 and wc-2. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q01371; P78714: wc-2; NbExp=5; IntAct=EBI-2922603, EBI-2924174;
CC       Q01371; Q9C3Y6: vvd; Xeno; NbExp=5; IntAct=EBI-2922603, EBI-2922644;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- INDUCTION: By blue light.
CC   -!- DOMAIN: The glutamine-rich domain might function in activating gene
CC       expression.
CC   -!- PTM: FMN binds covalently to cysteine after exposure to blue light and
CC       is reversed in the dark. {ECO:0000250}.
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DR   EMBL; X94300; CAA63964.2; -; Genomic_DNA.
DR   EMBL; CM002242; ESA41977.1; -; Genomic_DNA.
DR   EMBL; CM002242; ESA41978.1; -; Genomic_DNA.
DR   EMBL; CM002242; ESA41979.1; -; Genomic_DNA.
DR   EMBL; CM002242; ESA41980.1; -; Genomic_DNA.
DR   RefSeq; XP_011395150.1; XM_011396848.1.
DR   RefSeq; XP_011395151.1; XM_011396849.1.
DR   RefSeq; XP_011395152.1; XM_011396850.1.
DR   RefSeq; XP_011395153.1; XM_011396851.1.
DR   AlphaFoldDB; Q01371; -.
DR   SMR; Q01371; -.
DR   DIP; DIP-1155N; -.
DR   IntAct; Q01371; 2.
DR   MINT; Q01371; -.
DR   STRING; 367110.Q01371; -.
DR   EnsemblFungi; ESA41977; ESA41977; NCU02356.
DR   EnsemblFungi; ESA41978; ESA41978; NCU02356.
DR   EnsemblFungi; ESA41979; ESA41979; NCU02356.
DR   EnsemblFungi; ESA41980; ESA41980; NCU02356.
DR   GeneID; 3875924; -.
DR   KEGG; ncr:NCU02356; -.
DR   VEuPathDB; FungiDB:NCU02356; -.
DR   HOGENOM; CLU_007918_2_0_1; -.
DR   InParanoid; Q01371; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd00130; PAS; 3.
DR   CDD; cd00202; ZnF_GATA; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00320; GATA; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 3.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   SUPFAM; SSF55785; SSF55785; 3.
DR   TIGRFAMs; TIGR00229; sensory_box; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR   PROSITE; PS50112; PAS; 3.
PE   1: Evidence at protein level;
KW   Activator; Chromophore; DNA-binding; Flavoprotein; FMN; Metal-binding;
KW   Nucleus; Photoreceptor protein; Receptor; Reference proteome; Repeat;
KW   Sensory transduction; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1167
FT                   /note="White collar 1 protein"
FT                   /id="PRO_0000083489"
FT   DOMAIN          381..452
FT                   /note="PAS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DOMAIN          469..508
FT                   /note="PAC 1"
FT   DOMAIN          574..644
FT                   /note="PAS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DOMAIN          650..691
FT                   /note="PAC 2"
FT   DOMAIN          693..763
FT                   /note="PAS 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   ZN_FING         934..959
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..952
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1047
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1060..1167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..865
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        968..1047
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1107..1137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         428
FT                   /note="S-4a-FMN cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1167 AA;  127454 MW;  6489D04DAB50EE38 CRC64;
     MNNNYYGSPL SPEELQHQMH QHQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ HQHQQQQKTN
     QHRNAGMMNT PPTTNQGNST IHASDVTMSG GSDSLDEIIQ QNLDEMHRRR SVPQPYGGQT
     RRLSMFDYAN PNDGFSDYQL DNMSGNYGDM TGGMGMSGHS SPYAGQNIMA MSDHSGGYSH
     MSPNVMGNMM TYPNLNMYHS PPIENPYSSA GLDTIRTDFS MDMNMDSGSV SAASVHPTPG
     LNKQDDEMMT MEQGFGGGDD ANASHQAQQN MGGLTPAMTP AMTPAMTPGV SNFAQGMATP
     VSQDAASTPA TTFQSPSLSA TTQTIRIGPP PPPSVTNAPT PAPFTSTPSG GGASQTKSIY
     SKSGFDMLRA LWYVASRKDP KLKLGAVDMS CAFVVCDVTL NDCPIIYVSD NFQNLTGYSR
     HEIVGRNCRF LQAPDGNVEA GTKREFVENN AVYTLKKTIA EGQEIQQSLI NYRKGGKPFL
     NLLTMIPIPW DTEEIRYFIG FQIDLVECPD AIIGQEGNGP MQVNYTHSDI GQYIWTPPTQ
     KQLEPADGQT LGVDDVSTLL QQCNSKGVAS DWHKQSWDKM LLENADDVVH VLSLKGLFLY
     LSPACKKVLE YDASDLVGTS LSSICHPSDI VPVTRELKEA QQHTPVNIVF RIRRKNSGYT
     WFESHGTLFN EQGKGRKCII LVGRKRPVFA LHRKDLELNG GIGDSEIWTK VSTSGMFLFV
     SSNVRSLLDL LPENLQGTSM QDLMRKESRA EFGRTIEKAR KGKIASCKHE VQNKRGQVLQ
     AYTTFYPGDG GEGQRPTFLL AQTKLLKASS RTLAPATVTV KNMSPGGVPL SPMKGIQTDS
     DSNTLMGGMS KSGSSDSTGA MVSARSSAGP GQDAALDADN IFDELKTTRC TSWQYELRQM
     EKVNRMLAEE LAQLLSNKKK RKRRKGGGNM VRDCANCHTR NTPEWRRGPS GNRDLCNSCG
     LRWAKQTGRV SPRTSSRGGN GDSMSKKSNS PSHSSPLHRE VGNDSPSTTT ATKNSPSLRG
     SSTTAPGTIT TDSGPAVASS ASGTGSTTIA TSANSAASTV NALGPPATGP SGGSPAQHLP
     PHLQGTHLNA QAMQRVHQHK QHQQHQQQHQ QQHQQQHQQQ HQQLQQHQFN PPQSQPLLEG
     GSGFRGSGME MTSIREEMGE HQQGLSV
 
 
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