WCAB_SHIFL
ID WCAB_SHIFL Reviewed; 162 AA.
AC P0ACD1; P77558;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Putative colanic acid biosynthesis acetyltransferase WcaB;
DE EC=2.3.1.-;
GN Name=wcaB; OrderedLocusNames=SF2122, S2246;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- PATHWAY: Slime biogenesis; slime polysaccharide biosynthesis.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000305}.
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DR EMBL; AE005674; AAN43660.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP17488.1; -; Genomic_DNA.
DR RefSeq; NP_707953.2; NC_004337.2.
DR RefSeq; WP_000888740.1; NZ_WPGW01000038.1.
DR AlphaFoldDB; P0ACD1; -.
DR SMR; P0ACD1; -.
DR STRING; 198214.SF2122; -.
DR EnsemblBacteria; AAN43660; AAN43660; SF2122.
DR EnsemblBacteria; AAP17488; AAP17488; S2246.
DR GeneID; 1026331; -.
DR GeneID; 66674044; -.
DR KEGG; sfl:SF2122; -.
DR KEGG; sfx:S2246; -.
DR PATRIC; fig|198214.7.peg.2531; -.
DR HOGENOM; CLU_051638_10_2_6; -.
DR OMA; FGRWRYT; -.
DR OrthoDB; 1639008at2; -.
DR UniPathway; UPA00936; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0009001; F:serine O-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045228; P:slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03354; LbH_SAT; 1.
DR InterPro; IPR024027; Colanic_acid_synth_WcaB.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR045304; LbH_SAT.
DR InterPro; IPR005881; Ser_O-AcTrfase.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR Pfam; PF00132; Hexapep; 1.
DR PIRSF; PIRSF000441; CysE; 1.
DR SUPFAM; SSF51161; SSF51161; 1.
DR TIGRFAMs; TIGR04016; WcaB; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW Repeat; Transferase.
FT CHAIN 1..162
FT /note="Putative colanic acid biosynthesis acetyltransferase
FT WcaB"
FT /id="PRO_0000068735"
SQ SEQUENCE 162 AA; 17616 MW; F2462F836F3FB3AD CRC64;
MLEDLRANSW SLRPCCMVLA YRVAHFCSVW RKKNVLNNLW AAPLLVLYRI ITECFFGYEI
QAAATIGRRF TIHHGYAVVI NKNVVAGDDF TIRHGVTIGN RGADNMACPH IGNGVELGAN
VIILGDITLG NNVTVGAGSV VLDSVPDNAL VVGEKARVKV IK
