ID   WCAC_ECOLI              Reviewed;         405 AA.
AC   P71237; P76386; Q2MAY2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Putative colanic acid biosynthesis glycosyl transferase WcaC;
GN   Name=wcaC; OrderedLocusNames=b2057, JW2042;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=8759852; DOI=10.1128/jb.178.16.4885-4893.1996;
RA   Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.;
RT   "Organization of the Escherichia coli K-12 gene cluster responsible for
RT   production of the extracellular polysaccharide colanic acid.";
RL   J. Bacteriol. 178:4885-4893(1996).
RN   [2]
RP   SEQUENCE REVISION TO 9-54.
RC   STRAIN=K12;
RA   Reeves P.R.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- PATHWAY: Slime biogenesis; slime polysaccharide biosynthesis.
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DR   EMBL; U38473; AAC77838.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75118.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76574.1; -; Genomic_DNA.
DR   PIR; H64971; H64971.
DR   RefSeq; NP_416561.1; NC_000913.3.
DR   RefSeq; WP_001023871.1; NZ_LN832404.1.
DR   AlphaFoldDB; P71237; -.
DR   BioGRID; 4260675; 294.
DR   BioGRID; 850926; 1.
DR   DIP; DIP-11119N; -.
DR   IntAct; P71237; 6.
DR   STRING; 511145.b2057; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   PaxDb; P71237; -.
DR   PRIDE; P71237; -.
DR   EnsemblBacteria; AAC75118; AAC75118; b2057.
DR   EnsemblBacteria; BAE76574; BAE76574; BAE76574.
DR   GeneID; 946579; -.
DR   KEGG; ecj:JW2042; -.
DR   KEGG; eco:b2057; -.
DR   PATRIC; fig|1411691.4.peg.194; -.
DR   EchoBASE; EB3341; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_009583_28_0_6; -.
DR   InParanoid; P71237; -.
DR   OMA; GKPVVWT; -.
DR   PhylomeDB; P71237; -.
DR   BioCyc; EcoCyc:G7102-MON; -.
DR   BioCyc; MetaCyc:G7102-MON; -.
DR   UniPathway; UPA00936; -.
DR   PRO; PR:P71237; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0035250; F:UDP-galactosyltransferase activity; IDA:EcoCyc.
DR   GO; GO:0009242; P:colanic acid biosynthetic process; IGC:EcoCyc.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045228; P:slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR023916; Colanic_acid_synth_WcaC.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR028098; Glyco_trans_4-like_N.
DR   Pfam; PF13439; Glyco_transf_4; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR04015; WcaC; 1.
PE   4: Predicted;
KW   Lipopolysaccharide biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..405
FT                   /note="Putative colanic acid biosynthesis glycosyl
FT                   transferase WcaC"
FT                   /id="PRO_0000065954"
FT   CONFLICT        232
FT                   /note="L -> F (in Ref. 2; AAC77838)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   405 AA;  45260 MW;  9A321E69131E3665 CRC64;
     MNILQFNVRL AEGGAAGVAL DLHQRALQQG LASHFVYGYG KGGKESVSHQ NYPQVIKHTP
     RMTAMANIAL FRLFNRDLFG NFNELYRTIT RTAGPVVLHF HVLHSYWLNL KSVVRFCEKV
     KNHKPDVTLV WTLHDHWSVT GRCAFTDGCE GWKTGCQKCP TLNNYPPVKI DRAHQLVAGK
     RQLFREMLAL GCQFISPSQH VADAFNSLYG PGRCRIINNG IDMATEAILA DLPPVRETQG
     KPKIAVVAHD LRYDGKTNQQ LVREMMALGD KIELHTFGKF SPFTAGNVVN HGFETDKRKL
     MSALNQMDAL VFSSRVDNYP LILCEALSIG VPVIATHSDA AREVLQKSGG KTVSEEEVLQ
     LVQLSKPEIA QAIFGTTLAE FSQRSRAAYS GQQMLEEYVN FYQNL