ID   WCAE_ECOLI              Reviewed;         248 AA.
AC   P71239; P76384; Q2MAY4;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Putative colanic acid biosynthesis glycosyl transferase WcaE;
GN   Name=wcaE; OrderedLocusNames=b2055, JW2040;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=8759852; DOI=10.1128/jb.178.16.4885-4893.1996;
RA   Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.;
RT   "Organization of the Escherichia coli K-12 gene cluster responsible for
RT   production of the extracellular polysaccharide colanic acid.";
RL   J. Bacteriol. 178:4885-4893(1996).
RN   [2]
RP   SEQUENCE REVISION.
RC   STRAIN=K12;
RA   Reeves P.R.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- PATHWAY: Slime biogenesis; slime polysaccharide biosynthesis.
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DR   EMBL; U38473; AAC77840.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75116.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76572.1; -; Genomic_DNA.
DR   PIR; F64971; F64971.
DR   RefSeq; NP_416559.1; NC_000913.3.
DR   RefSeq; WP_000927089.1; NZ_LN832404.1.
DR   AlphaFoldDB; P71239; -.
DR   SMR; P71239; -.
DR   BioGRID; 4259696; 170.
DR   BioGRID; 850890; 1.
DR   DIP; DIP-11121N; -.
DR   IntAct; P71239; 1.
DR   STRING; 511145.b2055; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   PaxDb; P71239; -.
DR   PRIDE; P71239; -.
DR   EnsemblBacteria; AAC75116; AAC75116; b2055.
DR   EnsemblBacteria; BAE76572; BAE76572; BAE76572.
DR   GeneID; 946543; -.
DR   KEGG; ecj:JW2040; -.
DR   KEGG; eco:b2055; -.
DR   PATRIC; fig|1411691.4.peg.196; -.
DR   EchoBASE; EB3343; -.
DR   eggNOG; COG1216; Bacteria.
DR   HOGENOM; CLU_025996_21_1_6; -.
DR   InParanoid; P71239; -.
DR   OMA; CAGNIEI; -.
DR   PhylomeDB; P71239; -.
DR   BioCyc; EcoCyc:G7100-MON; -.
DR   BioCyc; MetaCyc:G7100-MON; -.
DR   UniPathway; UPA00936; -.
DR   PRO; PR:P71239; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0008417; F:fucosyltransferase activity; IDA:EcoCyc.
DR   GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0009242; P:colanic acid biosynthetic process; IGC:EcoCyc.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045228; P:slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR024010; Colanic_acid_synth_WcaE.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR04009; wcaE; 1.
PE   4: Predicted;
KW   Lipopolysaccharide biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..248
FT                   /note="Putative colanic acid biosynthesis glycosyl
FT                   transferase WcaE"
FT                   /id="PRO_0000065956"
SQ   SEQUENCE   248 AA;  27894 MW;  46B4381A5E9DFD9D CRC64;
     MLLSIITVAF RNLEGIVKTH ASLAHLAQVE DISFEWIVVD GGSNDGTREY LENLNGIFNL
     RFVSEPDNGI YDAMNKGIAM AQGKFALFLN SGDIFHQNAA NFVRKLKMQK DNVMITGDAL
     LDFGDGHKIK RSAKPGWYIY HSLPASHQAI FFPVSGLKKW RYDLEYKVSS DYALAAKMYK
     AGYAFKKLNG LVSEFSMGGV STTNNMELCA DAKKVQRQIL HVPGFWAELS WHLRQRTTSK
     TKALYNKV