WCSD_DROME
ID WCSD_DROME Reviewed; 317 AA.
AC Q9VXV9; B4F678; B4F682; B4F683; B4F685;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=WSCD family member CG9164;
GN ORFNames=CG9164;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-317, AND VARIANTS ALA-105; ARG-147;
RP ARG-148; LEU-149; LEU-214 AND ILE-218.
RC STRAIN=ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL229, ZBMEL377,
RC ZBMEL384, ZBMEL84, and ZBMEL95;
RX PubMed=18477586; DOI=10.1093/molbev/msn111;
RA Baines J.F., Sawyer S.A., Hartl D.L., Parsch J.;
RT "Effects of X-linkage and sex-biased gene expression on the rate of
RT adaptive protein evolution in Drosophila.";
RL Mol. Biol. Evol. 25:1639-1650(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WSCD family. {ECO:0000305}.
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DR EMBL; AE014298; AAN09664.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09665.1; -; Genomic_DNA.
DR EMBL; AY069087; AAL39232.1; -; mRNA.
DR EMBL; AM999314; CAQ53676.1; -; Genomic_DNA.
DR EMBL; AM999315; CAQ53677.1; -; Genomic_DNA.
DR EMBL; AM999316; CAQ53678.1; -; Genomic_DNA.
DR EMBL; AM999317; CAQ53679.1; -; Genomic_DNA.
DR EMBL; AM999318; CAQ53680.1; -; Genomic_DNA.
DR EMBL; AM999319; CAQ53681.1; -; Genomic_DNA.
DR EMBL; AM999320; CAQ53682.1; -; Genomic_DNA.
DR EMBL; AM999321; CAQ53683.1; -; Genomic_DNA.
DR EMBL; AM999322; CAQ53684.1; -; Genomic_DNA.
DR RefSeq; NP_573021.1; NM_132793.3.
DR RefSeq; NP_727846.1; NM_167439.2.
DR RefSeq; NP_727847.1; NM_167440.3.
DR AlphaFoldDB; Q9VXV9; -.
DR SMR; Q9VXV9; -.
DR STRING; 7227.FBpp0073829; -.
DR GlyGen; Q9VXV9; 3 sites.
DR PaxDb; Q9VXV9; -.
DR DNASU; 32467; -.
DR EnsemblMetazoa; FBtr0074012; FBpp0073829; FBgn0030634.
DR EnsemblMetazoa; FBtr0074014; FBpp0073831; FBgn0030634.
DR EnsemblMetazoa; FBtr0343351; FBpp0310008; FBgn0030634.
DR GeneID; 32467; -.
DR KEGG; dme:Dmel_CG9164; -.
DR UCSC; CG9164-RA; d. melanogaster.
DR FlyBase; FBgn0030634; CG9164.
DR VEuPathDB; VectorBase:FBgn0030634; -.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000169474; -.
DR HOGENOM; CLU_052719_0_0_1; -.
DR InParanoid; Q9VXV9; -.
DR OMA; EQLMRCA; -.
DR OrthoDB; 809004at2759; -.
DR PhylomeDB; Q9VXV9; -.
DR BioGRID-ORCS; 32467; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 32467; -.
DR PRO; PR:Q9VXV9; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030634; Expressed in brain and 8 other tissues.
DR ExpressionAtlas; Q9VXV9; baseline and differential.
DR Genevisible; Q9VXV9; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..317
FT /note="WSCD family member CG9164"
FT /id="PRO_0000305069"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 105
FT /note="T -> A (in strain: ZBMEL377)"
FT /evidence="ECO:0000269|PubMed:18477586"
FT VARIANT 147
FT /note="E -> R (in strain: ZBMEL157)"
FT /evidence="ECO:0000269|PubMed:18477586"
FT VARIANT 148
FT /note="N -> R (in strain: ZBMEL157)"
FT /evidence="ECO:0000269|PubMed:18477586"
FT VARIANT 149
FT /note="V -> L (in strain: ZBMEL157)"
FT /evidence="ECO:0000269|PubMed:18477586"
FT VARIANT 214
FT /note="Q -> L (in strain: ZBMEL186)"
FT /evidence="ECO:0000269|PubMed:18477586"
FT VARIANT 218
FT /note="N -> I (in strain: ZBMEL186)"
FT /evidence="ECO:0000269|PubMed:18477586"
SQ SEQUENCE 317 AA; 36608 MW; BA846665A1E5448F CRC64;
MALQGWRFFG VSATIIIYIG GVLFLSMNNI PGSHPKRPRI ERFAEFPSFH SPRFPMPSRK
MTIRWCRDLK YINRDLPIYA DYKSDFYTAL PSDVSAALQS LPALTALASF PGSGNTWLRY
LLQQATGILT GSIYKDYGLL KTGFPAENVC NSSVLLVKTH EWGSKAWAPF SKAILLVRDP
EKAIIAEFNR QSGGHIGFAS PDRYKRTKGK YWQQFVSNKL KGWEMMNLSW ARNFTGSIKV
VFYDDLVHHT ERELRSILDF LQFPINEQLM RCAIMRKEGI FRRKKRLLSF DPYTESMRAE
VQNRRRIVYG LLGRQEP
