ID   WCWK2_STREE             Reviewed;         332 AA.
AC   Q4K0R3;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Capsular polysaccharide phosphotransferase WcwK;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein WcwK;
GN   Name=wcwK; ORFNames=SPC21_0011;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=546/62 / Serotype 21;
RX   PubMed=16532061; DOI=10.1371/journal.pgen.0020031;
RA   Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA   Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA   Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA   Spratt B.G.;
RT   "Genetic analysis of the capsular biosynthetic locus from all 90
RT   pneumococcal serotypes.";
RL   PLoS Genet. 2:262-268(2006).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; CR931680; CAI33742.1; -; Genomic_DNA.
DR   RefSeq; WP_044793508.1; NZ_WNHT01000069.1.
DR   AlphaFoldDB; Q4K0R3; -.
DR   PRIDE; Q4K0R3; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..332
FT                   /note="Capsular polysaccharide phosphotransferase WcwK"
FT                   /id="PRO_0000235968"
SQ   SEQUENCE   332 AA;  38562 MW;  036542EA258C7AEA CRC64;
     MNKIDFVVTW VDGNDPVWKE KKSRYDGSVS TSKQSMNSVK AYREWGTFKY WFRGVERFAP
     WVNKVYLVTD QQRPSWLDIN SEKLVLVDHT EIICNDCLPV FSANPIESNI HRIPGLSEHF
     VFFNDDMYLT APVEPTDFFS EDGLPKYNTA LSPIIPERYG TGNFQINDME IVTSYFSRNE
     ILKNGQFFDP KQGLKSIVKS LLYRNSQFIC GFWESHLPYP LLKSTMDLIW EKEKAVLGRT
     SASRFRNPSD TNVWLFKYWQ IASGQYAVGN PKLGRLFSLD NAGPDFWNLL NSGKYKIMCI
     NDVYDIKDEE KVMQEFIAAM KNLLPDKSTF EL